Allogeneic cell interactions during graft rejection inCallyspongia diffusa(Porifera, Demospongia); a study with monoclonal antibodies

The Royal Society - Tập 226 Số 1245 - Trang 465-477 - 1986
L. Courtney Smith1, W. H. Hildemann1
1Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California 90024, U.S.A.

Tóm tắt

Many aspects of the cellular immune system in the marine spongeCallyspongia diffusa, have been defined by using artificially transplanted allogeneic tissues. Rejections show specificity of ‘non-self’ recognition, cytotoxic effector responses and short-term immunological memory. Histological investigations reveal a generalized mesohyl migration to the graft zone where archaeocytes line up at the allogeneic interface. Monoclonal antibodies (mAbs) raised to sponge cells have shown that little or no allogeneic cell mixing occurs at the graft interface and that certain mesohyl cell types do not appear to be directly involved in graft rejections. However, all mesohyl cell types are present in autograft fusion zones and in inflammatory responses to injury. The involvement of only some of the mesohyl cell types in graft rejections suggests specific interactions of an effector ‘immunocyte'.

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