Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism

Food and Chemical Toxicology - Tập 62 - Trang 292-298 - 2013
Young Suk Jung1, Sun Ju Kim1, Do Young Kwon1, Chul Won Ahn1, Young Soon Kim2, Dal Woong Choi3, Young Chul Kim1,4
1College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Ku, Seoul 151-742, Republic of Korea
2Department of Food & Nutrition, College of Health Sciences, Korea University, San-1 Jeongneung-Dong, Seongbuk-Ku, Seoul 136-703, Republic of Korea
3Department of Environmental Health, College of Health Sciences, Korea University, San-1 Jeongneung-Dong, Seongbuk-Ku, Seoul 136-703, Republic of Korea
4Research Institute of Pharmaceutical Sciences, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Ku, Seoul 151-742, Republic of Korea

Tài liệu tham khảo

Arteel, 2003, Oxidants and antioxidants in alcohol-induced liver disease, Gastroenterology, 124, 778, 10.1053/gast.2003.50087 Bagley, 1995, Anal. Biochem., 227, 40, 10.1006/abio.1995.1250 Barak, 2003, Betaine lowers elevated s-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats, J. Nutr., 133, 2845, 10.1093/jn/133.9.2845 Bode, 2005, Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?, Alcohol. Clin. Exp. Res., 29, 166S, 10.1097/01.alc.0000189280.19073.28 Caro, 2004, Antioxidant properties of S-adenosyl-methionine in Fe2+-initiated oxidations, Free Radical Biol. Med., 36, 1303, 10.1016/j.freeradbiomed.2004.02.015 Chawla, 1998, S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury, Am. J. Physiol., 275, G125 Colell, 1998, Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor, Gastroenterology, 115, 1541, 10.1016/S0016-5085(98)70034-4 Day, 1998, Hepatic steatosis: innocent bystander or guilty party?, Hepatology, 27, 1463, 10.1002/hep.510270601 Duce, 1988, S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis, Hepatology, 8, 65, 10.1002/hep.1840080113 Fernández-Checa, 2002, S-adenosyl-l-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease, Alcohol, 27, 179, 10.1016/S0741-8329(02)00229-X Gaitonde, 1967, A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids, Biochem. J., 104, 627, 10.1042/bj1040627 García-Tevijano, 2001, Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis, Hypertension, 38, 1217, 10.1161/hy1101.099499 Griffith, 1980, Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine, Anal. Biochem., 106, 207, 10.1016/0003-2697(80)90139-6 Habig, 1974, Glutathione S-transferases. The first enzymatic step in mercapturic acid formation, J. Biol. Chem., 249, 7130, 10.1016/S0021-9258(19)42083-8 Ide, 1997, Simple high-performance liquid chromatographic method for assaying cysteinesulfinic acid decarboxylase activity in rat tissue, J. Chromatogr. B Biomed. Sci. Appl., 694, 325, 10.1016/S0378-4347(97)00128-X Ji, 2004, Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury, World J. Gastroenterol., 10, 1699, 10.3748/wjg.v10.i12.1699 Kashiwamata, 1970, Studies on cystathionine synthase of rat liver. Properties of the highly purified enzyme, Biochim. Biophys. Acta, 212, 488, 10.1016/0005-2744(70)90255-X Kharbanda, 2007, Role of transmethylation reactions in alcoholic liver disease, World J. Gastroenterol., 13, 4947, 10.3748/wjg.v13.i37.4947 Kharbanda, 2007, Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, J. Hepatol., 46, 314, 10.1016/j.jhep.2006.08.024 Kharbanda, 2012, Betaine treatment attenuates chronic ethanol-induced hepatic steatosis and alterations to the mitochondrial respiratory chain proteome, Int. J. Hepatol., 10.1155/2012/962183 Kim, 2009, Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice, J. Hepatol., 50, 1184, 10.1016/j.jhep.2009.01.030 Kim, 2003, Effect of acute betaine administration on hepatic metabolism of S-amino acids in rats and mice, Biochem. Pharmacol., 65, 1565, 10.1016/S0006-2952(03)00115-1 Kim, 2002, Attenuation of bacterial lipopolysaccharide-induced hepatotoxicity by betaine or taurine in rats, Food Chem. Toxicol., 40, 545, 10.1016/S0278-6915(01)00102-8 Kim, 2005, Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice, J. Hepatol., 42, 907, 10.1016/j.jhep.2005.01.017 Kim, 2009, Alleviation of dimethylnitrosamine-induced liver injury and fibrosis by betaine supplementation in rats, Chem. Biol. Interact., 177, 204, 10.1016/j.cbi.2008.09.021 Kim, 2005, Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate, Food Chem. Toxicol., 43, 663, 10.1016/j.fct.2004.12.015 Kwon, 2009, Impaired sulfur–amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats, J. Nutr., 139, 63, 10.3945/jn.108.094771 Kwon, 2001, Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes, Am. J. Physiol. Endocrinol. Metab., 280, E804, 10.1152/ajpendo.2001.280.5.E804 Lee, 2004, Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis, Alcohol. Clin. Exp. Res., 28, 173, 10.1097/01.ALC.0000108654.77178.03 Lieber, 1989, Experimental methods of ethanol administration, Hepatology, 10, 501, 10.1002/hep.1840100417 MacSween, 1986, Histologic spectrum of alcoholic liver disease, Semin. Liver Dis., 6, 221, 10.1055/s-2008-1040605 Matsuo, 1957, A crystalline enzyme that cleaves homoserine and cystathionine. I. Isolation procedure and some physicochemical properties, J. Biol. Chem., 230, 545, 10.1016/S0021-9258(18)70476-6 Rajendra, 1987, High performance liquid chromatographic determination of amino acids in biological samples by precolumn derivatization with O-phthdialdehyde, J. Liquid Chromatogr., 10, 941, 10.1080/01483918708066746 Regoli, 1999, Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals, Toxicol. Appl. Pharmacol., 156, 96, 10.1006/taap.1999.8637 She, 1994, A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver, Biochem. Biophys. Res. Commun., 205, 1748, 10.1006/bbrc.1994.2871 Shimizu-Saito, 1997, Differential expression of S-adenosylmethionine synthetase isozymes in different cell types of rat liver, Hepatology, 26, 424, 10.1002/hep.510260224 Shinohara, 2010, Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats, Hepatology, 51, 796, 10.1002/hep.23391 Steenge, 2003, Betaine supplementation lowers plasma homocysteine in healthy men and women, J. Nutr., 133, 1291, 10.1093/jn/133.5.1291 Stipanuk, 2004, The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver, Am. J. Physiol. Endocrinol. Metab., 286, E439, 10.1152/ajpendo.00336.2003 Ueki, 2009, 3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways, J. Nutr., 139, 207, 10.3945/jn.108.099085 Watson, 1999, S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha, Biochem. J., 342, 21, 10.1042/bj3420021 Yan, 1995, Fluorimetric determination of monobromobimane and o-phthalaldehyde adducts of gamma-glutamylcysteine and glutathione: application to assay of gamma-glutamylcysteinyl synthetase activity and glutathione concentration in liver, J. Chromatogr. B Biomed. Appl., 672, 217, 10.1016/0378-4347(95)00226-9