Albuminuria Is an Appropriate Therapeutic Target in Patients with CKD

Clinical journal of the American Society of Nephrology : CJASN - Tập 10 Số 6 - Trang 1079-1088 - 2015
Hiddo J.L. Heerspink1, Ron T. Gansevoort2
1Departments of Clinical Pharmacy and Pharmacology and [email protected].
2Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Gansevoort, 2009, Hermann Senator and albuminuria—forgotten pioneering work in the 19th century, Nephrol Dial Transplant, 24, 1057, 10.1093/ndt/gfn741

Williams, 1988, Renal pathology and proteinuria determine progression in untreated mild/moderate chronic renal failure, Q J Med, 67, 343

Johnson, 2011, Strengths and weaknesses of renal markers as risk factors and surrogate markers, Kidney Int, 79, 1272, 10.1038/ki.2011.61

Parving, 2015, Microalbuminuria: A parameter that has changed diabetes care, Diabetes Res Clin Pract, 107, 1, 10.1016/j.diabres.2014.10.014

Remuzzi, 1990, Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules?, Kidney Int, 38, 384, 10.1038/ki.1990.217

Abbate, 2006, How does proteinuria cause progressive renal damage?, J Am Soc Nephrol, 17, 2974, 10.1681/ASN.2006040377

Chen, 1997, Proteinuria and tubulointerstitial injury, Kidney Int Suppl, 61, S60

Okada, 2012, Histological predictors for renal prognosis in diabetic nephropathy in diabetes mellitus type 2 patients with overt proteinuria, Nephrology (Carlton, 17, 68, 10.1111/j.1440-1797.2011.01525.x

Birn, 2006, Renal albumin absorption in physiology and pathology, Kidney Int, 69, 440, 10.1038/sj.ki.5000141

Gekle, 2005, Renal tubule albumin transport, Annu Rev Physiol, 67, 573, 10.1146/annurev.physiol.67.031103.154845

Amsellem, 2010, Cubilin is essential for albumin reabsorption in the renal proximal tubule, J Am Soc Nephrol, 21, 1859, 10.1681/ASN.2010050492

Pollock, 2007, Albumin transport and processing by the proximal tubule: Physiology and pathophysiology, Curr Opin Nephrol Hypertens, 16, 359, 10.1097/MNH.0b013e3281eb9059

Birn, 2000, Cubilin is an albumin binding protein important for renal tubular albumin reabsorption, J Clin Invest, 105, 1353, 10.1172/JCI8862

Christensen, 2001, Megalin and cubilin: Synergistic endocytic receptors in renal proximal tubule, Am J Physiol Renal Physiol, 280, F562, 10.1152/ajprenal.2001.280.4.F562

Storm, 2013, Renal phenotypic investigations of megalin-deficient patients: Novel insights into tubular proteinuria and albumin filtration, Nephrol Dial Transplant, 28, 585, 10.1093/ndt/gfs462

Macconi, 2009, Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides, J Am Soc Nephrol, 20, 123, 10.1681/ASN.2007111233

Morigi, 2002, Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway, J Am Soc Nephrol, 13, 1179

Dixon, 1999, Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: Implications for the pathophysiology of proteinuric states, J Am Soc Nephrol, 10, 1487, 10.1681/ASN.V1071487

Drumm, 2002, Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1), Cell Physiol Biochem, 12, 187, 10.1159/000066278

Lee, 2003, Effects of pathophysiological concentrations of albumin on NHE3 activity and cell proliferation in primary cultures of human proximal tubule cells, Am J Physiol Renal Physiol, 285, F748, 10.1152/ajprenal.00442.2002

Wang, 1997, Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein, J Am Soc Nephrol, 8, 1537, 10.1681/ASN.V8101537

Zoja, 1998, Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation, Kidney Int, 53, 1608, 10.1046/j.1523-1755.1998.00905.x

Vlachojannis, 2002, Endothelin-1 in the kidney and urine of patients with glomerular disease and proteinuria, Clin Nephrol, 58, 337, 10.5414/CNP58337

Zoja, 1995, Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins, Am J Kidney Dis, 26, 934, 10.1016/0272-6386(95)90058-6

Whaley-Connell, 2007, Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells, Am J Nephrol, 27, 15, 10.1159/000098432

Diwakar, 2007, The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells, Am J Physiol Renal Physiol, 292, F1464, 10.1152/ajprenal.00069.2006

Goumenos, 2002, Transforming growth factor-beta(1) in the kidney and urine of patients with glomerular disease and proteinuria, Nephrol Dial Transplant, 17, 2145, 10.1093/ndt/17.12.2145

Stephan, 2004, Albumin stimulates the accumulation of extracellular matrix in renal tubular epithelial cells, Am J Nephrol, 24, 14, 10.1159/000075347

Roscioni, 2014, Microalbuminuria: Target for renoprotective therapy PRO, Kidney Int, 86, 40, 10.1038/ki.2013.490

van der Velde, 2009, Screening for albuminuria identifies individuals at increased renal risk, J Am Soc Nephrol, 20, 852, 10.1681/ASN.2008060655

Gansevoort, 2011, Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts, Kidney Int, 80, 93, 10.1038/ki.2010.531

Agarwal, 2014, A prospective study of multiple protein biomarkers to predict progression in diabetic chronic kidney disease, Nephrol Dial Transplant, 29, 2293, 10.1093/ndt/gfu255

Hallan, 2009, Combining GFR and albuminuria to classify CKD improves prediction of ESRD, J Am Soc Nephrol, 20, 1069, 10.1681/ASN.2008070730

Rigalleau, 2007, Normoalbuminuric renal-insufficient diabetic patients: A lower-risk group, Diabetes Care, 30, 2034, 10.2337/dc07-0140

Packer, 1991, Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group, N Engl J Med, 325, 1468, 10.1056/NEJM199111213252103

Kramer, 2006, Sodium intake modifies the negative prognostic value of renal damage prior to treatment with ACE inhibitors on proteinuria induced by adriamycin, Nephron Physiol, 103, 43, 10.1159/000090222

Lambers Heerspink, 2012, Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers, Kidney Int, 82, 330, 10.1038/ki.2012.74

Vegter, 2012, Sodium intake, ACE inhibition, and progression to ESRD, J Am Soc Nephrol, 23, 165, 10.1681/ASN.2011040430

Inker, 2014, Early change in proteinuria as a surrogate end point for kidney disease progression: An individual patient meta-analysis, Am J Kidney Dis, 64, 74, 10.1053/j.ajkd.2014.02.020

Hou, 2007, Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: A randomized controlled study of benazepril and losartan in chronic renal insufficiency, J Am Soc Nephrol, 18, 1889, 10.1681/ASN.2006121372

Navarro-González, 2015, Effect of Pentoxifylline on Renal Function and Urinary Albumin Excretion in Patients with Diabetic Kidney Disease: The PREDIAN Trial, J Am Soc Nephrol, 26, 220, 10.1681/ASN.2014010012

Group, 1995, Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial, Kidney Int, 47, 1703, 10.1038/ki.1995.236

de Boer, 2011, Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes, N Engl J Med, 365, 2366, 10.1056/NEJMoa1111732

Perkovic, 2013, Intensive glucose control improves kidney outcomes in patients with type 2 diabetes, Kidney Int, 83, 517, 10.1038/ki.2012.401

Klahr, 1994, The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease, N Engl J Med, 330, 877, 10.1056/NEJM199403313301301

Levey, 1999, Dietary protein restriction and the progression of chronic renal disease: What have all of the results of the MDRD study shown? Modification of Diet in Renal Disease Study group, J Am Soc Nephrol, 10, 2426, 10.1681/ASN.V10112426

Ruggenenti, 2008, Role of remission clinics in the longitudinal treatment of CKD, J Am Soc Nephrol, 19, 1213, 10.1681/ASN.2007090970

de Zeeuw, 2004, Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL, Kidney Int, 65, 2309, 10.1111/j.1523-1755.2004.00653.x

Xie, 2011, High level of proteinuria during treatment with renin-angiotensin inhibitors is a strong predictor of renal outcome in nondiabetic kidney disease, J Clin Pharmacol, 51, 1025, 10.1177/0091270010377502

Mann, 2008, Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial, Lancet, 372, 547, 10.1016/S0140-6736(08)61236-2

Parving, 2012, Cardiorenal end points in a trial of aliskiren for type 2 diabetes, N Engl J Med, 367, 2204, 10.1056/NEJMoa1208799

Fried, 2013, Combined angiotensin inhibition for the treatment of diabetic nephropathy, N Engl J Med, 369, 1892, 10.1056/NEJMoa1303154

Jafar, 2001, Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease, Kidney Int, 60, 1131, 10.1046/j.1523-1755.2001.0600031131.x

Tobe, 2011, Cardiovascular and renal outcomes with telmisartan, ramipril, or both in people at high renal risk: Results from the ONTARGET and TRANSCEND studies, Circulation, 123, 1098, 10.1161/CIRCULATIONAHA.110.964171

Lambers Heerspink, 2011, ONTARGET still OFF-TARGET?, Circulation, 123, 1049, 10.1161/CIRCULATIONAHA.111.018382

Lassere, 2008, The Biomarker-Surrogacy Evaluation Schema: A review of the biomarker-surrogate literature and a proposal for a criterion-based, quantitative, multidimensional hierarchical levels of evidence schema for evaluating the status of biomarkers as surrogate endpoints, Stat Methods Med Res, 17, 303, 10.1177/0962280207082719

Moynihan, 2011, Surrogates under scrutiny: Fallible correlations, fatal consequences, BMJ, 343, d5160, 10.1136/bmj.d5160

Atkins, 2005, Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy, Am J Kidney Dis, 45, 281, 10.1053/j.ajkd.2004.10.019

Lea, 2005, The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: Results of the African American study of kidney disease and hypertension, Arch Intern Med, 165, 947, 10.1001/archinte.165.8.947

Ruggenenti, 2003, Retarding progression of chronic renal disease: The neglected issue of residual proteinuria, Kidney Int, 63, 2254, 10.1046/j.1523-1755.2003.00033.x

Roscioni, 2013, A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus, Diabetologia, 56, 259, 10.1007/s00125-012-2755-2

Schmieder, 2011, Changes in albuminuria predict mortality and morbidity in patients with vascular disease, J Am Soc Nephrol, 22, 1353, 10.1681/ASN.2010091001