Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes
Tóm tắt
Từ khóa
Tài liệu tham khảo
Trimboli, 2008, Direct evidence for epithelial-mesenchymal transitions in breast cancer, Cancer Res, 68, 937, 10.1158/0008-5472.CAN-07-2148
Castanon, 2002, A Twist in fate: evolutionary comparison of Twist structure and function, Gene, 287, 11, 10.1016/S0378-1119(01)00893-9
Chen, 1995, twist is required in head mesenchyme for cranial neural tube morphogenesis, Genes Dev, 9, 686, 10.1101/gad.9.6.686
Ansieau, 2008, Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence, Cancer Cell, 14, 79, 10.1016/j.ccr.2008.06.005
Yang, 2004, Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, 117, 927, 10.1016/j.cell.2004.06.006
Lee, 2006, Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clin Cancer Res, 12, 5369, 10.1158/1078-0432.CCR-05-2722
Puisieux, 2006, A twist for survival and cancer progression, Br J Cancer, 94, 13, 10.1038/sj.bjc.6602876
Vichalkovski, 2010, PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage, Oncogene, 29, 3554, 10.1038/onc.2010.115
Lo, 2007, Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression, Cancer Res, 67, 9066, 10.1158/0008-5472.CAN-07-0575
Tzankov, 2005, Tissue microarray technology: principles, pitfalls and perspectives-lessons learned from hematological malignancies, Exp Gerontol, 737
Oskarsson, 2011, Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs, Nat Med, 17, 867, 10.1038/nm.2379
Klopp, 2007, Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment, Cancer Res, 67, 11687, 10.1158/0008-5472.CAN-07-1406
Dey, 2010, Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis, Cancer Res, 70, 4151, 10.1158/0008-5472.CAN-09-4479
Schor, 2001, Phenotypic and genetic alterations in mammary stroma: implications for tumour progression, Breast Cancer Res, 3, 373, 10.1186/bcr325
Chekhun, 2009, Stroma-regulator of cancer cell progression, Exp Oncol, 31, 126
Massague, 1998, TGF-beta signal transduction, Annu Rev Biochem, 67, 753, 10.1146/annurev.biochem.67.1.753
Hoshino, 2011, Autocrine TGF-beta protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim, J Biochem, 149, 55, 10.1093/jb/mvq114
Muraoka, 2002, Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases, J Clin Invest, 109, 1551, 10.1172/JCI0215234
McEarchern, 2001, Invasion and metastasis of a mammary tumor involves TGF-beta signaling, Int J Cancer, 91, 76, 10.1002/1097-0215(20010101)91:1<76::AID-IJC1012>3.0.CO;2-8
Bakin, 2000, Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration, J Biol Chem, 275, 36803, 10.1074/jbc.M005912200
Scholtz, 1996, Transcription of the transforming growth factor-beta2 gene is dependent on an E-box located between an essential cAMP response element/activating transcription factor motif and the TATA box of the gene, J Biol Chem, 271, 32375, 10.1074/jbc.271.50.32375
Thiery, 2006, Complex networks orchestrate epithelial-mesenchymal transitions, Nat Rev Mol Cell Biol, 7, 131, 10.1038/nrm1835
Thiery, 2009, Epithelial-mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007
Perez-Tenorio, 2002, Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients, Br J Cancer, 86, 540, 10.1038/sj.bjc.6600126
Scheid, 2001, PKB/AKT: functional insights from genetic models, Nat Rev Mol Cell Biol, 2, 760, 10.1038/35096067
Vivanco, 2002, The phosphatidylinositol 3-Kinase AKT pathway in human cancer, Nat Rev Cancer, 2, 489, 10.1038/nrc839
Mattila, 2008, Filopodia: molecular architecture and cellular functions, Nat Rev Mol Cell Biol, 9, 446, 10.1038/nrm2406
Casas, 2011, Snail2 is an essential mediator of Twist1-induced epithelial-mesenchymal transition and metastasis, Cancer Res, 71, 245, 10.1158/0008-5472.CAN-10-2330
Sanford, 1997, TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes, Development, 124, 2659, 10.1242/dev.124.13.2659
Jakowlew, 2006, Transforming growth factor-beta in cancer and metastasis, Cancer Metastasis Rev, 25, 435, 10.1007/s10555-006-9006-2
Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat Rev Cancer, 3, 807, 10.1038/nrc1208
Scheel, 2011, Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast, Cell, 145, 926, 10.1016/j.cell.2011.04.029
Eckert, 2011, Twist1-induced invadopodia formation promotes tumor metastasis, Cancer Cell, 19, 372, 10.1016/j.ccr.2011.01.036
Lamouille, 2007, Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway, J Cell Biol, 178, 437, 10.1083/jcb.200611146
Padua, 2008, TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4, Cell, 133, 66, 10.1016/j.cell.2008.01.046
Zhang, 2009, Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain, Cancer Res, 69, 828, 10.1158/0008-5472.CAN-08-2588
Schlingensiepen, 2008, Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors, Recent Results Cancer Res, 177, 137, 10.1007/978-3-540-71279-4_16
Siegel, 2003, Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis, Proc Natl Acad Sci U S A, 100, 8430, 10.1073/pnas.0932636100
Muraoka, 2003, Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1, Mol Cell Biol, 23, 8691, 10.1128/MCB.23.23.8691-8703.2003
Ueda, 2004, Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility, J Biol Chem, 279, 24505, 10.1074/jbc.M400081200
Janda, 2002, Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway, Oncogene, 21, 5148, 10.1038/sj.onc.1205661
Janda, 2002, Ras and TGF [beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways, J Cell Biol, 156, 299, 10.1083/jcb.200109037
Wang, 2008, Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab, Mol Cell Biol, 28, 5605, 10.1128/MCB.00787-08
Seton-Rogers, 2004, ErbB2 and TGF-beta: a cooperative role in mammary tumor progression?, Cell Cycle, 3, 597, 10.4161/cc.3.5.886
Seton-Rogers, 2004, Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells, Proc Natl Acad Sci U S A, 101, 1257, 10.1073/pnas.0308090100
Liu, 2006, Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions, J Biol Chem, 281, 31380, 10.1016/S0021-9258(19)84050-4