Air oxidation of d‐limonene (the citrus solvent) creates potent allergens

Contact Dermatitis - Tập 26 Số 5 - Trang 332-340 - 1992
Ann‐Therése Karlberg1, Kerstin Magnusson1, Ulrika Nilsson2
1Department of Occupational Dermatology. National Institute of Occupational Health, National Institute of Occupational Health, Solna, Sweden
2Department of Analytical Chemistry, National Institute of Occupational Health, Solna, Sweden

Tóm tắt

Products containing as much as 95% of d‐limonene are used for, e.g., degreasing metal before industrial painting and for cleaning assemblies. Experimental studies on the sensitizing potential of limonene show diverging results. In a previous study, we found that the sensitizing potential of d‐limonene increased with prolonged air exposure. The aim of 1 his study was to make further chemical analyses, to identify compounds formed by air exposure of d‐limonende and to study their allergenic potential. d‐limonene was found lo be a sensitizer after prolonged exposure to air according to 2 Freund's complete adjuvant test (FCAT) experiments and I guinea pig maximization test (GPMT) study. No significant response was obtained to d‐limonene air exposed, even if the animals were sensitized to oxidized d‐limonene. 5 main oxidation products of d‐limoncne were identified. (R)‐(–)‐carvone and a mixture of cis and trans isomers of (+)‐limonene oxide were found to he potent sensitizers, while no significant reactions were obtained m the animals induced with 8 mixture of cis and trans isomers of (–)‐carveol. It can be concluded that air oxidation of d‐limonene is essential for its sensitizing potential, and that potent allergens are created.

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Contact Dermatitis

Tập 26 Số 5

332-340

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