Aggressive oncocytic neuroendocrine tumour (‘oncocytic paraganglioma’) of the cauda equina
Tóm tắt
An oncocytic neuroendocrine tumour (‘oncocytic paraganglioma’) of the cauda equina is reported. The tumour was predominantly intradural, with extension into and destruction of surrounding vertebral bone. The tumour had an organoid pattern, and the tumour cells had abundant non‐argyrophilic eosinophilic cytoplasm. Immunocytochemical stains for neurone‐specific enolase, S‐100 protein, keratin and carcinoembyronic antigen were positive, but stains for glial fibrillary acidic protein were negative. On ultrastructural examination, there were numerous mitochondria and scattered 200 nm dense‐core membrane‐bound granules, that rarely clustered in small aggregates. Intermediate filaments were focally arranged in long compact bundles. The histogenesis of tumours reported as cauda equina paragangliomas is discussed.
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Tài liệu tham khảo
Bauserman S.C., 1978, Pituitary oncocytoma. Indispensible role of electron microscopy in its identification, Archives of Pathology and Laboratory Medicine, 102, 456
Blobel G.A., 1985, Coexpression of neuroendocrine markers and epithelial cytoskeletal proteins in bronchopulmonary neuroendocrine neoplasms, Laboratory Investigation, 52, 39
Churukian C.J., 1979, A modification of Pascual's argyrophil method, Journal of Histotechnology, 2, 102, 10.1179/his.1979.2.3.102
Gallivan M.V.E., 1980, Intrathoracic paravertebral malignant paraganglioma, Archives of Pathology and Laboratory Medicine, 104, 46
Jago R., 1984, Electron microscopy of carotid body hyperplasia, Archives of Pathology and Laboratory Medicine, 108, 717
Lagacé R., 1978, Paraganglioma of the filum terminale, Le Journal Canadien des Sciences Neurologiques, 5, 257
Miettinen M., 1985, Varying expression of cytokeratin and neurofilaments in neuroendocrine tumours of the human gastrointestinal tract, Laboratory Investigation, 52, 429
Sidhu G.S., 1979, The endodermal origin of digestive and respiratory tract APUD cells. Histopathologic evidence and a review of the literature, American Journal of Pathology, 96, 5