Aggressive Angiomyxoma

Archives of Pathology and Laboratory Medicine - Tập 136 Số 2 - Trang 217-221 - 2012
Brian J. Sutton1, Jennifer Laudadio2,1
1Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina
2Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157

Tóm tắt

Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with nonspecific symptoms which are frequently misdiagnosed with more common entities, such as a Bartholin cyst, lipoma, or hernia. Histologic examination reveals a hypocellular and highly vascular tumor with a myxoid stroma containing cytologically bland stellate or spindled cells. The tumor cells are characteristically positive for estrogen and progesterone receptors, suggesting a hormonal role in the development of the tumor. Chromosomal translocation of the 12q13-15 band involving the HMGA2 gene has been described. Surgical excision is the treatment of choice, although treatment with gonadotropin-releasing hormone agonists is an emerging therapy. Metastases are exceedingly rare, and overall, the prognosis is good.

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Tài liệu tham khảo

Steeper, 1983, Aggressive angiomyxoma of the female pelvis and perineum: report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm, Am J Surg Pathol, 7, 463, 10.1097/00000478-198307000-00009

Chan, 2000, Aggressive angiomyxoma in females: is radical resection the only option, Acta Obstet Gynecol Scand, 79, 216, 10.1080/j.1600-0412.2000.079003216.x

Amezcua, 2005, Aggressive angiomyxoma of the female genital tract: a clinicopathologic and immunohistochemical study of 12 cases, Int J Gynecol Cancer, 15, 140, 10.1136/ijgc-00009577-200501000-00021

Fetsch, 1996, Aggressive angiomyxoma: a clinicopathologic study of 29 female patients, Cancer, 78, 79, 10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR13>3.0.CO;2-4

White, 1994, Aggressive angiomyxoma of the vulva in an 11-year-old girl, Pediatr Pathol, 14, 27, 10.3109/15513819409022023

Iezzoni, 1995, Aggressive angiomyxoma in males: a report of four cases, Am J Clin Pathol, 104, 391, 10.1093/ajcp/104.4.391

Granter, 1997, Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases, Histopathology, 30, 3, 10.1046/j.1365-2559.1997.d01-556.x

Siassi, 1999, Metastasizing aggressive angiomyxoma, N Engl J Med, 341, 1772, 10.1056/NEJM199912023412315

Blandamura, 2003, Aggressive angiomyxoma: a second case of metastasis with patient's death, Hum Pathol, 34, 1072, 10.1053/S0046-8177(03)00419-2

Magtibay, 2006, Aggressive angiomyxoma of the female pelvis and perineum: a case series, Int J Gynecol Cancer, 16, 396, 10.1111/j.1525-1438.2006.00225.x

Nakamura, 2002, Aggressive angiomyxoma of the perineum originating from the rectal wall, J Gastroenterol, 37, 303, 10.1007/s005350200040

Nyam, 1998, Large aggressive angiomyxoma of the perineum and pelvis: an alternative approach: report of a case, Dis Colon Rectum, 41, 514, 10.1007/BF02235768

Haldar, 2010, Aggressive angiomyxoma: a case series and literature review, Eur J Surg Oncol, 36, 335, 10.1016/j.ejso.2009.11.006

Jeyadevan, 2003, Imaging features of aggressive angiomyxoma, Clin Radiol, 58, 157, 10.1053/crad.2002.1127

Outwater, 1999, Aggressive angiomyxoma: findings on CT and MR imaging, AJR Am J Roentgenol, 172, 435, 10.2214/ajr.172.2.9930798

McCluggage, 2005, A review and update of morphologically bland vulvovaginal mesenchymal lesions, Int J Gynecol Pathol, 24, 26

Smith, 1991, Aggressive angiomyxoma of the female pelvis and perineum: review of the literature, Gynecol Oncol, 42, 79, 10.1016/0090-8258(91)90235-W

Kazmierczak, 1995, Cytogenic and molecular analysis of an aggressive angiomyxoma, Am J Pathol, 147, 580

Rabban, 2006, HMGA2 rearrangement in a case of vulvar aggressive angiomyxoma, Int J Gynecol Pathol, 25, 403, 10.1097/01.pgp.0000209572.54457.7b

Dreux, 2010, Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases, Mod Pathol, 23, 1657, 10.1038/modpathol.2010.174

Fletcher, 1992, Angiomyofibroblastoma of the vulva: a benign neoplasm distinct from aggressive angiomyxoma, Am J Surg Pathol, 16, 373, 10.1097/00000478-199204000-00006

Nucci, 2000, Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma, Am J Surg Pathol, 24, 231, 10.1097/00000478-200002000-00009

Weiss, 2008, Aggressive angiomyxoma, Enzinger and Weiss's Soft Tissue Tumors. 5th ed, 1081

Rhomberg, 2000, Aggressive angiomyxoma: irradiation for recurrent disease, Strahlenther Onkol, 176, 324, 10.1007/s000660050015

Suleiman, 2006, Pelvic excision of large aggressive angiomyxoma in a woman: irradiation for recurrent disease, Int J Gynecol Cancer, 16, 356, 10.1136/ijgc-00009577-200602001-00063

Htwe, 1995, Hormone-dependent, aggressive angiomyxoma of the vulva, Obstet Gynecol, 86, 697, 10.1016/0029-7844(95)00088-9

Fine, 2001, Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist, Gynecol Oncol, 81, 120, 10.1006/gyno.2000.6119

McCluggage, 2006, Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy, Gynecol Oncol, 100, 623, 10.1016/j.ygyno.2005.09.033

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Archives of Pathology and Laboratory Medicine

Tập 136 Số 2

217-221

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