Sự tham gia của tế bào mast ở ruột và histamine trong viêm sau đột quỵ phụ thuộc vào độ tuổi

Springer Science and Business Media LLC - 2020
Maria Pilar Blasco1, Anjali Chauhan1, Pedram Honarpisheh1, Hilda Ahnstedt1, John d’Aigle1, Arunkumar Ganesan2, Sriram Ayyaswamy2, Frank W Blixt1, Susan Venable3, Angela Major3, David J. Durgan2, Anthony M. Haag3, Julia Kofler4, Robert M. Bryan2, Louise D. McCullough1, Bhanu Priya Ganesh1
1Department of Neurology, University of Texas McGovern Medical School, Houston, USA
2Department of Anesthesiology, Baylor College of Medicine, Houston, USA
3Department of Pathology and Immunology, Baylor College of Medicine, Houston, USA
4Department of Pathology, University of Pittsburg, Pittsburgh, USA

Tóm tắt

Tóm tắt Nền tảng Nguy cơ mắc các bệnh liên quan đến đột quỵ và tử vong tăng lên đáng kể theo độ tuổi. Lão hóa liên quan đến tình trạng viêm mạn tính với mức độ thấp, được cho là góp phần vào những kết quả xấu hơn sau đột quỵ ở người cao tuổi. Histamine (HA) là một môi trường phân tử chính trong quá trình viêm, và tế bào mast tồn tại trong ruột là nguồn histamine chính. Phương pháp Đột quỵ được gây ra ở chuột đực C57BL/6 J ở tuổi 3 tháng (trẻ) và 20 tháng (già). Vai trò của histamine sau đột quỵ được xem xét bằng cách sử dụng chuột trẻ (Yg) và chuột già (Ag); chuột đã trải qua phẫu thuật MCAO và được đưa ra ngoài sống tại 6 giờ, 24 giờ, và 7 ngày sau thiếu máu cục bộ; chuột sham đã nhận được cùng một ca phẫu thuật nhưng không có MCAO. Trong nghiên cứu này, chúng tôi đã đánh giá xem các kết quả xấu hơn sau đột quỵ thí nghiệm ở chuột già có liên quan đến các thay đổi theo độ tuổi trong tế bào mast, mức độ histamine, và sự biểu hiện thụ thể histamine trong ruột, não và huyết thanh hay không. Kết quả Chúng tôi phát hiện thấy số lượng tế bào mast tăng lên ở ruột và não theo độ tuổi. Sử dụng mô hình tắc động mạch não giữa (MCAO) của đột quỵ thiếu máu, chúng tôi chứng minh rằng đột quỵ dẫn đến số lượng tế bào mast ở ruột tăng và mức độ biểu hiện thụ thể histamine ở ruột tăng lên. Những thay đổi tập trung vào ruột này đi kèm với mức độ HA và các cytokine viêm khác như IL-6, G-CSF, TNF-α, và IFN-γ trong tuần hoàn ngoại biên tăng cao. Dữ liệu của chúng tôi cũng cho thấy rằng viêm ruột sau đột quỵ dẫn đến sự giảm đáng kể số lượng tế bào hình ống tiết mucin và mất tính toàn vẹn của rào cản ruột. Cuối cùng, viêm ruột sau đột quỵ liên quan đến sự thay đổi trong thành phần của hệ vi sinh vật đường ruột ngay từ 24 giờ sau đột quỵ.

Từ khóa


Tài liệu tham khảo

Bentsen L, et al. Outcome and risk factors presented in old patients above 80 years of age versus younger patients after ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(7):1944–8.

Durgan DJ, et al. Examining the role of the microbiota-gut-brain axis in stroke. Stroke. 2019;50(8):2270–7.

Furman D, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822–32.

Biran V, et al. Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain. Brain Pathol. 2008;18(1):1–9.

Ganesh BP, et al. Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice. PLoS One. 2013;8(9):e74963.

Ganesh BP, et al. Enterococcus faecium NCIMB 10415 does not protect interleukin-10 knock-out mice from chronic gut inflammation. Benef Microbes. 2012;3(1):43–50..

Ganesh BP, Versalovic J. Luminal conversion and immunoregulation by probiotics. Front Pharmacol. 2015;6:269.

Ganesh BP, et al. Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. Mucosal Immunol. 2018;11(2):380–93..

Dong H, Zhang X, Qian Y. Mast cells and neuroinflammation. Med Sci Monit Basic Res. 2014;20:200–6.

Bulfone-Paus S, et al. Positive and negative signals in mast cell activation. Trends Immunol. 2017;38(9):657–67.

Christy AL, et al. Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE. J Autoimmun. 2013;42:50–61.

Jin Y, Silverman AJ, Vannucci SJ. Mast cells are early responders after hypoxia-ischemia in immature rat brain. Stroke. 2009;40(9):3107–12.

Kempuraj D, et al. Mast cell activation in brain injury, stress, and post-traumatic stress disorder and Alzheimer’s disease pathogenesis. Front Neurosci. 2017;11:703.

Nakazawa S, et al. Histamine synthesis is required for granule maturation in murine mast cells. Eur J Immunol. 2014;44(1):204–14.

Parsons ME, Ganellin CR. Histamine and its receptors. Br J Pharmacol. 2006;147(Suppl 1):S127–35.

Strbian D, et al. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation. 2007;116(4):411–8.

De Winter BY, van den Wijngaard RM, de Jonge WJ. Intestinal mast cells in gut inflammation and motility disturbances. Biochim Biophys Acta. 2012;1822(1):66–73.

Bieganski T, et al. Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism. Biochim Biophys Acta. 1983;756(2):196–203.

Dwyer DF, et al. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016;17(7):878–87.

Hallgren J, Gurish MF. Mast cell progenitor trafficking and maturation. Adv Exp Med Biol. 2011;716:14–28.

Tuttolomondo A, et al. Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis. Atherosclerosis. 2009;203(2):503–8.

Albanese A, et al. Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII. Report of three cases. J Neurosurg. 2005;102(6):1130–2.

Anrather J, Iadecola C. Inflammation and stroke: an overview. Neurotherapeutics. 2016;13(4):661–70.

Stanley D, Moore RJ, Wong CHY. An insight into intestinal mucosal microbiota disruption after stroke. Sci Rep. 2018;8(1):568.

Crapser J, et al. Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice. Aging (Albany NY). 2016;8(5):1049–63.

Thangam EB, et al. The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets. Front Immunol. 2018;9:1873.

Sander LE, et al. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut. 2006;55(4):498–504.

Lieberman P. The basics of histamine biology. Ann Allergy Asthma Immunol. 2011;106(2 Suppl):S2–5.

Arac A, et al. Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol. 2014;184(9):2493–504.

Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185–96.

Chatterjee V, Gashev AA. Aging-associated shifts in functional status of mast cells located by adult and aged mesenteric lymphatic vessels. Am J Physiol Heart Circ Physiol. 2012;303(6):H693–702.

Kim H, et al. Effects of the female estrous cycle on the sexual behaviors and ultrasonic vocalizations of male C57BL/6 and autistic BTBR T+ tf/J mice. Exp Neurobiol. 2016;25(4):156–62.

Engevik MA, et al. Acidic conditions in the NHE2(-/-) mouse intestine result in an altered mucosa-associated bacterial population with changes in mucus oligosaccharides. Cell Physiol Biochem. 2013;32(7):111–28.

Hollister EB, et al. Structure and function of the healthy pre-adolescent pediatric gut microbiome. Microbiome. 2015;3:36.

Spychala MS, et al. Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. Ann Neurol. 2018.

Ritzel RM, et al. Aging alters the immunological response to ischemic stroke. Acta Neuropathol. 2018;136(1):89–110.

Ritzel RM, et al. Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury. J Immunol. 2016;196(8):3318–30.

Gabay, C., Interleukin-6 and chronic inflammation. Arthritis Res Ther, 2006. 8 Suppl 2: p. S3.

McCarty MF. Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: down-regulation with essential fatty acids, ethanol and pentoxifylline. Med Hypotheses. 1999;52(5):465–77.

Scheller J, Ohnesorge N, Rose-John S. Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand J Immunol. 2006;63(5):321–9.

Desai, A., et al., IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3. J Allergy Clin Immunol, 2016. 137(6): p. 1863-1871 e6.

Conti P, et al. Interleukin-6 and mast cells. Allergy Asthma Proc. 2002;23(5):331–5.

Kinoshita T, et al. Interleukin-6 directly modulates stem cell factor-dependent development of human mast cells derived from CD34(+) cord blood cells. Blood. 1999;94(2):496–508.

McHale C, et al. Interleukin-6 potentiates FcεRI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells. Biochim Biophys Acta. 2018;1862(5):1069–78.

Nechushtan H, et al. Inhibition of degranulation and interleukin-6 production in mast cells derived from mice deficient in protein kinase Cbeta. Blood. 2000;95(5):1752–7.

Johansson ME, Hansson GC. Mucus and the goblet cell. Dig Dis. 2013;31(3-4):305–9.

Pelaseyed T, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev. 2014;260(1):8–20.

Shi N, et al. Interaction between the gut microbiome and mucosal immune system. Mil Med Res. 2017;4:14.

Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML. Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab. 2010;30(4):689–702.

Gao C, et al. Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri. MBio. 2015;6(6):e01358–15.

Cornick S, Tawiah A, Chadee K. Roles and regulation of the mucus barrier in the gut. Tissue Barriers. 2015;3(1-2):e982426.

Zaitsu M, et al. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol. 2007;44(8):1977–85.

Cacabelos R, et al. Histamine and immune biomarkers in CNS disorders. Mediators Inflamm. 2016;2016:1924603.

Leary PJ, et al. Histamine H2 receptor antagonists, left ventricular morphology, and heart failure risk: the MESA study. J Am Coll Cardiol. 2016;67(13):1544–52.

Malagelada C, et al. Histamine H2-receptor antagonist ranitidine protects against neural death induced by oxygen-glucose deprivation. Stroke. 2004;35(10):2396–401.

Chauhan A, et al. Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. J Neuroinflammation. 2018;15(1):148.

Galli SJ, Maurer M, Lantz CS. Mast cells as sentinels of innate immunity. Curr Opin Immunol. 1999;11(1):53–9.

Benjamin EJ, et al. Heart Disease and Stroke Statistics-2019 Update: a report from the American Heart Association. Circulation. 2019;139(10):e56–e528.

Manwani B, et al. Differential effects of aging and sex on stroke induced inflammation across the lifespan. Exp Neurol. 2013;249:120–31.

Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87(5):779–89.

Akhavein MA, et al. Allergic mastocytic gastroenteritis and colitis: an unexplained etiology in chronic abdominal pain and gastrointestinal dysmotility. Gastroenterol Res Pract. 2012;2012:950582.

Chapman KZ, et al. A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke. J Cereb Blood Flow Metab. 2009;29(11):1764–8.

Wollin A, Navert H, Bounous G. Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Gastroenterology. 1981;80(2):349–55.

Baylin SB, et al. Age-related abnormalities of circulating polyamines and diamine oxidase activity in cystic fibrosis heterozygotes and homozygotes. Pediatr Res. 1980;14(8):921–5.

Kaser A, Blumberg RS. Endoplasmic reticulum stress and intestinal inflammation. Mucosal Immunol. 2010;3(1):11–6.

McGuckin MA, et al. Mucin dynamics and enteric pathogens. Nat Rev Microbiol. 2011;9(4):265–78.

Fan XH, Cheng L, Yan AH. Ameliorative effect of acetylshikonin on ovalbumin (OVA)-induced allergic rhinitis in mice through the inhibition of Th2 cytokine production and mast cell histamine release. APMIS. 2019;127(10):688–95.

Hayashi D, et al. Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Invest Ophthalmol Vis Sci. 2012;53(6):2993–3003.

Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9(11):799–809.

Barletta JF. Clinical and economic burden of opioid use for postsurgical pain: focus on ventilatory impairment and ileus. Pharmacotherapy. 2012;32(9 Suppl):12S–8S.

Ohkusa T, et al. Gut microbiota and chronic constipation: a review and update. Front Med (Lausanne). 2019;6:19.

Broughton BR, et al. Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells. Front Cell Neurosci. 2012;6:66.

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