Age and sex differences in reward behavior in adolescent and adult rats

Developmental Psychobiology - Tập 56 Số 4 - Trang 611-621 - 2014
Lindsey R. Hammerslag1, Joshua M. Gulley2
1Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana-Champaign, IL.
2Department of Psychology and Neuroscience Program University of Illinois, Urbana‐Champaign 731 Psychology Bldg MC‐716, 603 E Daniel St Urbana‐Champaign IL 61820

Tóm tắt

ABSTRACTCompared to adults, adolescents are at heightened risk for drug abuse and dependence. One of the factors contributing to this vulnerability may be age‐dependent differences in reward processing, with adolescents approaching reward through stimulus‐directed, rather than goal‐directed, processes. However, the empirical evidence for this in rodent models of adolescence, particularly those that investigate both sexes, is limited. To address this, male and female rats that were adolescents (P30) or adults (P98) at the start of the experiment were trained in a Pavlovian approach (PA) task and were subsequently tested for the effects of reward devaluation, extinction, and re‐acquisition. We found significant interactions between age and sex: females had enhanced acquisition of PA and poorer extinction, relative to males, while adolescents and females were less sensitive to reward devaluation than male adults. These results suggest that females and adolescents exhibit reward behavior that is more stimulus‐directed, rather than goal‐directed. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 611–621, 2014.

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Tài liệu tham khảo

10.1111/j.1530‐0277.2010.01307.x

10.1037/a0022038

10.1007/s00213‐009‐1721‐2

10.1007/s00213‐011‐2181‐z

10.1037/0735‐7044.122.2.460

10.1016/j.neubiorev.2011.04.013

10.1016/j.bbr.2012.01.046

10.1038/npp.2011.44

10.1016/j.yhbeh.2009.10.001

10.1037/a0016128

10.1176/appi.ajp.160.6.1041

10.1007/s00213‐005‐2152‐3

10.1038/nn.2558

10.3758/BF03199951

10.1037/a0023763

10.1016/j.bandc.2009.08.008

10.1016/j.dcn.2011.07.013

10.1017/S0033291705005891

10.1016/j.pbb.2008.12.013

10.1038/nn1579

10.1016/j.yhbeh.2004.04.009

10.3389/fnbeh.2010.00039

10.1007/s00213‐004‐2080‐7

10.3389/neuro.09.006.2010

10.1523/JNEUROSCI.1062‐06.2006

10.1037/0012‐1649.41.4.625

10.1016/0091-3057(79)90293-4

10.1016/S0091-3057(99)00181-1

10.1007/s00213‐008‐1089‐8

10.1002/dev.20543

10.1080/00952990802082206

10.1016/j.yhbeh.2009.10.015

10.1016/j.neubiorev.2006.06.001

10.1007/s00213‐009‐1502‐y

10.1016/j.bbr.2010.04.011

10.1007/s00213‐007‐1028‐0

10.1007/s00213‐002‐1183‐2

10.1016/S0091-3057(01)00455-5

10.1097/FBP.0b013e3282effbf5

10.1002/dev.20381

10.1523/JNEUROSCI.3080‐12.2012

10.1523/JNEUROSCI.5443‐06.2007

10.1016/j.ddmod.2009.07.004

10.1016/S0278‐2626(03)00279‐3

10.1152/jn.00756.2012

10.1037/1064‐1297.16.2.165

10.1523/JNEUROSCI.23-35-11078.2003

10.15288/jsa.1999.60.252

10.3758/BF03199014

10.1016/j.neuron.2005.07.018

10.1007/s00213‐009‐1585‐5

10.1007/s00213‐007‐0933‐6

10.1016/j.bbr.2011.07.003

10.1016/j.bbr.2010.08.048

10.1007/s00213‐006‐0373‐8

10.1016/j.bandc.2009.07.003

10.1016/S0149-7634(00)00014-2

10.1016/j.dcn.2011.08.001

10.1037/a0012955

10.1037/a0018463

10.1016/S0149‐7634(03)00018‐6

10.1093/cercor/bhp078

10.1016/j.ntt.2008.04.002

10.1038/sj.npp.1300915

10.1073/pnas.0807423106

10.1016/j.pbb.2008.11.002

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Developmental Psychobiology

Tập 56 Số 4

611-621

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