African Americans are less likely to enroll in preclinical Alzheimer's disease clinical trials

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 57-64 - 2017
Yan Zhou1, David Elashoff2, Sarah Kremen2, Edmond Teng2,3, Jason Karlawish4, Joshua D. Grill5
1American Board of Anesthesiology, Raleigh, NC, USA
2Department of Neurology, Mary S. Easton Center for Alzheimer's Disease Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
3VA Greater Los Angeles Healthcare System, Los Angeles, CA USA
4Departments of Medicine and Medical Ethics and Health Policy, Alzheimer's Disease Core Center, Penn Neurodegenerative Disease Ethics and Policy Program, University of Pennsylvania, Philadelphia, PA, USA
5Department of Psychiatry and Human Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA

Tóm tắt

AbstractIntroductionAlzheimer's disease (AD) incidence is disproportionately high in African Americans, yet, recruitment of this community to AD clinical trials is challenging.MethodsWe compared 47 African Americans and 78 whites in their willingness to enroll in a hypothetical preclinical AD trial and examined barriers and facilitators in their decision making.ResultsAfrican American race (OR = 0.45; 95% CI, 0.22–0.93) and score on the research attitude questionnaire (OR = 1.12; 95% CI, 1.04–1.22) were independently associated with willingness to participate. African Americans rated study risks, the requirement of a study partner, study procedures, the ratio of drug to placebo, and study location as more important factors in the decision whether to enroll than did whites.DiscussionThese results suggest that researchers will encounter challenges in recruiting African Americans to preclinical AD trials. Future research will be necessary to understand the optimal means to improve recruitment of underrepresented populations.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 3

57-64

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