Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

American Association for the Advancement of Science (AAAS) - Tập 354 Số 6311 - Trang 481-484 - 2016
Min Peng1, Na Yin1, Sagar Chhangawala, Ke Xu2, Christina Leslie3, Ming O. Li1
1Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA
2Immunology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
3Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA

Tóm tắt

Metabolic support for T cell functions For immunological T cells, responding to infections is energetically demanding. T cells rewire their metabolism so that they rely more heavily on aerobic glycolysis. This helps them to support important effector functions such as secreting the cytokine interferon γ (IFNγ). Peng et al. now provide insight into how aerobic glycolysis promotes T cell effector function. Activated T cells express the aerobic glycolysis–supporting enzyme lactate dehydrogenase A (LDHA), allowing these cells to maintain high amounts of acetyl–coenzyme A, which in turn promotes histone acetylation and transcription of cytokines such as IFNγ. Engineered mice whose T cells lacked LDHA were protected from IFNγ-dependent pathologies that often characterize autoinflammatory diseases. Science , this issue p. 481

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American Association for the Advancement of Science (AAAS)

Tập 354 Số 6311

481-484

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