Adverse outcome pathways

Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, Serrrano JA, Tietge JE, Villeneuve DL (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 29(3):730–741. https://doi.org/10.1002/etc.34 Aschauer L, Carta G, Vogelsang N, Schlatter E, Jennings P (2015a) Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1. Toxicol In Vitro 30(1 Pt A):95–105 Aschauer L, Limonciel A, Wilmes A, Stanzel S, Kopp-Schneider A, Hewitt P, Lukas A, Leonard MO, Pfaller W, Jennings P (2015b) Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: a transcriptomic study. Toxicol In Vitro 30(1 Pt A):106–116 Carneiro MF, Morais C, Small DM, Vesey DA, Barbosa F Jr, Gobe GC (2015) Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro. Environ Toxicol 30(12):1423–1433 Choi K, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA (2016) Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients. Toxicol Lett 241:49–59 Deharde D, Schneider C, Hiller T, Fischer N, Kegel V, Lübberstedt M, Freyer N, Hengstler JG, Andersson TB, Seehofer D, Pratschke J, Zeilinger K, Damm G (2016) Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition. Arch Toxicol 90(10):2497–2511 Godoy P, Aranda M (2015) Highlight report: epoxide hydrolases-protection from reactive compounds and risk of cardiovascular disease. Arch Toxicol 89(12):2463–2464. https://doi.org/10.1007/s00204-015-1646-y Godoy P, Widera A, Schmidt-Heck W et al (2016) Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue. Arch Toxicol 90(10):2513–2529 Golka K (2015) Highlight report: xenobiotic-metabolizing enzymes in skin models. Arch Toxicol 89(12):2465–2467 Gómez-Lechón MJ, Tolosa L (2016) Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening. Arch Toxicol 90(9):2049–2061 Grinberg M, Stöber RM, Edlund K et al (2014) Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol 88(12):2261–2287 Hammad S, Mahmoud HY, Hamadneh L, Elsherief AM, Meindl-Beinker NM, Kotb AM (2016) Highlight report: pluripotent stem cells in translational research. Arch Toxicol 90(12):3145–3146 Jaworska JS, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M (2015) Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy. Arch Toxicol 89(12):2355–2383 Jennings P, Crean D, Aschauer L, Limonciel A, Moenks K, Kern G, Hewitt P, Lhotta K, Lukas A, Wilmes A, Leonard MO (2015) Interleukin-19 as a translational indicator of renal injury. Arch Toxicol 89(1):101–106 Leclerc E, Hamon J, Bois FY (2016) Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver-kidney microfluidic data and pharmacokinetic-system biology models. J Appl Toxicol 36(2):330–339 Leist M, Ghallab A, Graepel R et al (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch Toxicol. https://doi.org/10.1007/s00204-017-2045-3 (Epub ahead of print) Natsch A, Emter R (2015) Reporter cell lines for skin sensitization testing. Arch Toxicol 89(10):1645–1668. https://doi.org/10.1007/s00204-015-1555-0 (Review) Sonnenburg A, Schreiner M, Stahlmann R (2015) Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA). Arch Toxicol 89(12):2339–2344 Vedula EM, Alonso JL, Arnaout MA, Charest JL (2017) A microfluidic renal proximal tubule with active reabsorptive function. PLoS One 12(10):e0184330 Vinken M, Knapen D, Vergauwen L, Hengstler JG, Angrish M, Whelan M (2017) Adverse outcome pathways: a concise introduction for toxicologists. Arch Toxicol. https://doi.org/10.1007/s00204-017-2020-z (Epub ahead of print)