Adverse outcome pathways: opportunities, limitations and open questions

Fühner-Wieland's Sammlung von Vergiftungsfällen - Tập 91 Số 11 - Trang 3477-3505 - 2017
Marcel Leist1, Ahmed Ghallab2, Rabea Graepel3, Rosemarie Marchan2, Reham Hassan2, Susanne Hougaard Bennekou4, Alice Limonciel5, Mathieu Vinken6, Stefan Schildknecht1, Tanja Waldmann1, Erik H.J. Danen3, B. van Ravenzwaay7, Hennicke Kamp7, Iain Gardner8, Patrício Godoy2, Frédéric Bois9, Albert Braeuning10, Raymond Reif2, Franz Oesch11, Dirk Drasdo12, Stefan Höhme13, Michael Schwarz14, Thomas Hartung15, Thomas Braunbeck16, Joost B. Beltman3, Harry Vrieling17, Ferrán Sanz18, Anna Forsby19, Domenico Gadaleta20, Ciarán Fisher8, Jens M. Kelm21, David A. Fluri21, Gerhard Ecker22, Barbara Zdrazil22, Andrea Terron23, Paul Jennings24, Bart van der Burg25, Steven Dooley26, Annemarie H. Meijer27, Egon Willighagen28, Marvin Martens28, Chris T. Evelo28, Enrico Mombelli9, Olivier Taboureau29, Alberto Mantovani30, Barry Hardy31, Bjørn E. V. Koch27, Sylvia Escher32, Christoph van Thriel2, Cristina Cadenas2, Dinant Kroese33, Bob van de Water3, Jan G. Hengstler2
1In Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Box 657, Universitaetsstr. 10, 78457, Konstanz, Germany
2Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany
3Research Division of Drug Discovery and Safety, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
4The Danish EPA, Copenhagen, Denmark
5Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, 6020, Innsbruck, Austria
6Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium
7BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany
8Simcyp (A Certara Company), Sheffield, UK
9INERIS, DRC/VIVA/METO, Parc ALATA BP2, 60550, Verneuil en Halatte, France
10Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany
11Institute of Toxicology, University of Mainz, Mainz, Germany
12INRIA, Unit Rocquencourt, B.P.105, 78153, Le Chesnay Cedex, France
13Institute for Computer Science, University of Leipzig, Haertelstraße 16-18, 04107, Leipzig, Germany
14Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University, Tübingen, Germany
15Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
16Aquatic Ecology and Toxicology Section, Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, 69120, Heidelberg, Germany
17Department of Human Genetics, Leiden University Medical Center, Postal Zone S4-P, PO Box 9600, 2300 RC, Leiden, The Netherlands
18Research Programme on Biomedical Informatics (GRIB), Department of Health and Life Sciences, Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain
19Unit of Toxicology Sciences, Swetox, Karolinska Institutet, Forskargatan 20, SE-151 36, Södertälje, Sweden
20Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via la Masa 19, 20156, Milano, Italy
21InSphero AG, Wagistrasse 27, CH-8952, Schlieren, Switzerland
22Pharmacoinformatics Research Group, Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
23European Food Safety Authority (EFSA), Pesticide Unit, via Carlo Magno 1 A, 43126, Parma, Italy
24Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands
25BioDetection Systems B.V. (BDS), Science Park 406, 1098 XH Amsterdam, the Netherlands
26Section Molekular Hepatology, II. Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany
27Institute of Biology, Leiden University, 2333 CC, Leiden, The Netherlands
28Department of Bioinformatics, BiGCaT, NUTRIM, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
29Inserm UMR-S973, Molécules Thérapeutiques in silico, Paris Diderot University, Paris, France
30Istituto Superiore di Sanità, viale Regina Elena 299 (00161) Roma, Italy
31Douglas Connect GmbH, Bärmeggenweg 14, Zeiningen, 4314, Aargau, Switzerland
32Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM) Chemical Risk Assessment Group Manager Structure Activity Relationships/databases, and expert systems Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany
33TNO (Department of Risk Analysis of Products in Development), Zeist, The Netherlands

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