Adverse Drug Events and Medication Errors in African Hospitals: A Systematic Review

Drugs - Real World Outcomes - Tập 5 - Trang 1-24 - 2017
Alemayehu B. Mekonnen1,2, Tariq M. Alhawassi3,4, Andrew J. McLachlan1,5, Jo-anne E. Brien1,6
1Faculty of Pharmacy, University of Sydney, Sydney, Australia
2School of Pharmacy, University of Gondar, Gondar, Ethiopia
3College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
4Medication Safety Research Chair, King Saud University, Riyadh, Saudi Arabia
5Centre for Education and Research on Ageing, Concord Hospital, Sydney, Australia
6Faculty of Medicine, St Vincent’s Hospital Clinical School, University of New South Wales, Sydney, Australia

Tóm tắt

Medication errors and adverse drug events are universal problems contributing to patient harm but the magnitude of these problems in Africa remains unclear. The objective of this study was to systematically investigate the literature on the extent of medication errors and adverse drug events, and the factors contributing to medication errors in African hospitals. We searched PubMed, MEDLINE, EMBASE, Web of Science and Global Health databases from inception to 31 August, 2017 and hand searched the reference lists of included studies. Original research studies of any design published in English that investigated adverse drug events and/or medication errors in any patient population in the hospital setting in Africa were included. Descriptive statistics including median and interquartile range were presented. Fifty-one studies were included; of these, 33 focused on medication errors, 15 on adverse drug events, and three studies focused on medication errors and adverse drug events. These studies were conducted in nine (of the 54) African countries. In any patient population, the median (interquartile range) percentage of patients reported to have experienced any suspected adverse drug event at hospital admission was 8.4% (4.5–20.1%), while adverse drug events causing admission were reported in 2.8% (0.7–6.4%) of patients but it was reported that a median of 43.5% (20.0–47.0%) of the adverse drug events were deemed preventable. Similarly, the median mortality rate attributed to adverse drug events was reported to be 0.1% (interquartile range 0.0–0.3%). The most commonly reported types of medication errors were prescribing errors, occurring in a median of 57.4% (interquartile range 22.8–72.8%) of all prescriptions and a median of 15.5% (interquartile range 7.5–50.6%) of the prescriptions evaluated had dosing problems. Major contributing factors for medication errors reported in these studies were individual practitioner factors (e.g. fatigue and inadequate knowledge/training) and environmental factors, such as workplace distraction and high workload. Medication errors in the African healthcare setting are relatively common, and the impact of adverse drug events is substantial but many are preventable. This review supports the design and implementation of preventative strategies targeting the most likely contributing factors.

Tài liệu tham khảo

Benjamin DM. Reducing medication errors and increasing patient safety: case studies in clinical pharmacology. J Clin Pharmacol. 2003;43:768–83.

Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR, Lawthers AG, Newhouse JP, Weiler PC, Hiatt HH. Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice Study I. N Engl J Med. 1991;324:370–6.

Leape LL, Brennan TA, Laird N, Lawthers AG, Localio AR, Barnes BA, Hebert L, Newhouse JP, Weiler PC, Hiatt HH. The nature of adverse events in hospitalized patients: results of the Harvard Medical Practice Study II. N Engl J Med. 1991;324:377–84.

Kohn LT, Corrigan JM, Donaldson MS, editors. To err is human: building a safer health system. Washington, DC: National Academy Press; 2000.

Clancy CM. Ten years after to err is human. Am J Med Qual. 2009;24:525–8.

Makary MA, Daniel M. Medical error: the third leading cause of death in the US. BMJ. 2016;353:i2139.

Davis P. Health care as a risk factor. CMAJ. 2004;170:1688–9.

United Nations Department for General Assembly and Conference Management. United Nations regional groups of member states. http://www.un.org/depts/DGACM/RegionalGroups.shtml. Accessed 15 Aug 2015.

United Nations. The millennium development goals report, 2015. http://www.un.org/millenniumgoals/2015_MDG_Report/pdf/MDG%202015%20rev%20(July%201).pdf. Accessed 15 Aug 2015.

The World Bank. Health expenditure per capita. http://data.worldbank.org/indicator/SH.XPD.PCAP. Accessed 15 Aug 2015.

Isah AO, Pal SN, Olsson S, Dodoo A, Bencheikh RS. Specific features of medicines safety and pharmacovigilance in Africa. Ther Adv Drug Saf. 2012;3:25–34.

Runciman WB, Roughead EE, Semple SJ, Adams RJ. Adverse drug events and medication errors in Australia. Int J Qual Health Care. 2003;15:49–59.

Roughead EE, Semple SJ. Medication safety in acute care in Australia: where are we now? Part 1: a review of the extent and causes of medication problems 2002–2008. Aust New Zealand Health Policy. 2009;6:18.

Keers RN, Williams SD, Cooke J, Ashcroft DM. Causes of medication administration errors in hospitals: a systematic review of quantitative and qualitative evidence. Drug Saf. 2013;36:1045–67.

Keers RN, Williams SD, Cooke J, Ashcroft DM. Prevalence and nature of medication administration errors in health care settings: a systematic review of direct observational evidence. Ann Pharmacother. 2013;47:237–56.

Berdot S, Gillaizeau F, Caruba T, Prognon P, Durieux P, Sabatier B. Drug administration errors in hospital inpatients: a systematic review. PLoS One. 2013;8(6):e68856.

Lewis PJ, Dornan T, Taylor D, Tully MP, Wass V, Ashcroft DM. Prevalence, incidence and nature of prescribing errors in hospital inpatients: a systematic review. Drug Saf. 2009;32:379–89.

Tully MP, Ashcroft DM, Dornan T, Lewis PJ, Taylor D, Wass V. The causes of and factors associated with prescribing errors in hospital inpatients: a systematic review. Drug Saf. 2009;32:819–36.

Brady AM, Malone AM, Fleming S. A literature review of the individual and systems factors that contribute to medication errors in nursing practice. J Nurs Manag. 2009;17:679–97.

Alsulami Z, Conroy S, Choonara I. Medication errors in the Middle East countries: a systematic review of the literature. Eur J Clin Pharmacol. 2013;69:995–1008.

Mansouri A, Ahmadvand A, Hadjibabaie M, Kargar M, Javadi M, Gholami K. Types and severity of medication errors in Iran; a review of the current literature. Daru. 2013;21:49.

Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42:1017–25.

Bouvy JC, De Bruin ML, Koopmanschap MA. Epidemiology of adverse drug reactions in Europe: a review of recent observational studies. Drug Saf. 2015;38:437–53.

National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP). Defintion and types of medication errors. http://www.nccmerp.org/about-medication-errors. Accessed 30 Jun 2015.

Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape L. Relationship between medication errors and adverse drug events. J Gen Intern Med. 1995;10:199–205.

World Health Organization. International drug monitoring: the role of the hospital. World Health Organ Tech Rep Ser. 1969;425:5–24.

David Moher AL, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.

Smyth RMD, Gargon E, Kirkham J, Cresswell L, Golder S, Smyth R, Williamson P. Adverse drug reactions in children: a systematic review. PLoS One. 2012;7:e24061.

Salmasi S, Khan TM, Hong YH, Ming LC, Wong TW. Medication errors in the Southeast Asian countries: a systematic review. PLoS One. 2015;10:e0136545.

Aderemi-Williams RI, Awodele O, Boyle CA. Adverse drug reactions amongst adult patients admitted in Lagos State University Teaching Hospital Lagos, Nigeria. Curr Drug Saf. 2015;10:136–44.

Benkirane R, Pariente A, Achour S, Ouammi L, Azzouzi A, Soulaymani R. Prevalence and preventability of adverse drug events in a teaching hospital: a cross-sectional study. EMHJ. 2009;15:1145–55.

Cooke DI, van der Merwe W, Pudifin DJ. Hospital admissions for adverse reactions to drugs and deliberate self-poisoning. S AfrMed J. 1985;67:770–2.

Eshetie TC, Hailemeskel B, Mekonnen N, Paulos G, Mekonnen AB, Girma T. Adverse drug events in hospitalized children at Ethiopian University Hospital: a prospective observational study. BMC Pediatr. 2015;15:83.

Kiguba R, Karamagi C, Bird SM. Incidence, risk factors and risk prediction of hospital acquired suspected adverse drug reactions: a prospective cohort of Ugandan inpatients. BMJ Open. 2017;7:e010568. https://doi.org/10.1136/bmjopen-2015-010568.

Letaief M, El Mhamdi S, El-Asady R, Siddiqi S, Abdullatif A. Adverse events in a Tunisian hospital: results of a retrospective cohort study. Int J Qual Health Care. 2010;22:380–5.

Mabadeje AF, Ilawole CO. Adverse drug reactions in the medical wards of the Lagos University Teaching Hospital: an intensive study. Niger Med J. 1979;9:379–82.

Matsaseng T, Moodley J. Adverse events in gynaecology at King Edward VIII Hospital, Durban, South Africa. J Obstet Gynaecol. 2005;25:676–80.

Mehta U, Durrheim DN, Blockman M, Kredo T, Gounden R, Barnes KI. Adverse drug reactions in adult medical inpatients in a South African hospital serving a community with a high HIV/AIDS prevalence: prospective observational study. Br J Clin Pharmacol. 2008;65:396–406.

Mouton JP, Mehta U, Parrish AG, Wilson DPK, Stewart A, Njuguna CW, Kramer N, Maartens G, Blockman M, Cohen K. Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a cross sectional survey. Br J Clin Pharmacol. 2015;80:818–26.

Mouton JP, Njuguna C, Kramer N, Stewart A, Mehta U, Blockman M, et al. Adverse drug reactions causing admission to medical wards: a cross-sectional survey at 4 hospitals in South Africa. Medicine (Baltimore). 2016;95(19):e3437.

Oshikoya KA, Njokanma OF, Chukwura HA, Ojo IO. Adverse drug reactions in Nigerian children. Paed Perinat Drug Ther. 2007;8:81–8.

Oshikoya KA, Chukwura H, Njokanma OF, Senbanjo IO, Ojo I. Incidence and cost estimate of treating pediatric adverse drug reactions in Lagos, Nigeria. Sao Paulo Med J. 2011;129:153–64.

Tipping B, Kalula S, Badri M. The burden and risk factors for adverse drug events in older patients: a prospective cross-sectional study. S Afr Med J. 2006;96:1255–9.

Tumwikirize WA, Ogwal-Okeng JW, Vernby A, Anokbonggo WW, Gustafsson LL, Lundborg SC. Adverse drug reactions in patients admitted on internal medicine wards in district and regional hospitals in Uganda. Afr Health Sci. 2011;11:72–8.

Agalu A, Ayele Y, Bedada W, Woldie M. Medication prescribing errors in the intensive care unit of Jimma University Specialized Hospital, Southwest Ethiopia. J Multidiscip Healthc. 2011;4:377–82.

Ajemigbitse AA, Omole MK, Erhun WO. An assessment of the rate, types and severity of prescribing errors in a tertiary hospital in southwestern Nigeria. Afr J Med Med Sci. 2013;42:339–46.

Ajemigbitse AA, Omole MK, Osi-Ogbu OF, Erhun WO. A qualitative study of causes of prescribing errors among junior medical doctors in a Nigeria in-patient setting. Ann Afr Med. 2013;12:223–31.

Ajemigbitse AA, Omole MK, Ezike NC, Erhun WO. Assessment of the knowledge and attitudes of intern doctors to medication prescribing errors in a Nigeria tertiary hospital. J Basic Clin Pharm. 2014;5:7–14.

Ajemigbitse AA, Omole MK, Erhun WO. Effect of providing feedback and prescribing education on prescription writing: an intervention study. Ann Afr Med. 2016;15:1–6.

Alagha HZ, Badary OA, Ibrahim HM, Sabri NA. Reducing prescribing errors in the paediatric intensive care unit: an experience from Egypt. Acta Paediatrica. 2011;100:169–74.

Arulogun OS, Oluwole SK, Titiloye MA. Prescription errors prevalent in four units of a University Teaching Hospital in Nigeria. J Public Health Epidemiol. 2011;3:513–9.

Oshikoya KA, Ojo OI. Medication errors in paediatric outpatient prescriptions of a teaching hospital in Nigeria. Nig Q J Hosp Med. 2007;17:74–8.

Sada O, Melkie A, Shibeshi W. Medication prescribing errors in the medical intensive care unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. BMC Res Notes. 2015;8:448.

Yinusa W. Prescription error in an orthopaedic practice. Niger Postgrad Med J. 2004;11:37–9.

Yousif MA, Nizar S, Elmustafa MO, Mustafa MI, Bella MM. Investigation of medication prescribing errors in Wad Medani, Gezira, Sudan. Int J Risk Saf Med. 2011;23:11–6.

Zeleke A, Chanie T, Woldie M. Medication prescribing errors and associated factors at the pediatric wards of Dessie Referral Hospital, Northeast Ethiopia. Int Arch Med. 2014;7:18.

Acheampong F, Tetteh AR, Anto BP. Medication administration errors in an adult emergency department of a tertiary health care facility in Ghana. J Patient Saf. 2016;12(4):223–8.

Agalu A, Ayele Y, Bedada W, Woldie M. Medication administration errors in an intensive care unit in Ethiopia. Int Arch Med. 2012;5:15.

al Tehewy M, Fahim H, Gad NI, El Gafary M, Rahman SA. Medication administration errors in a university hospital. J Patient Saf. 2016;12:34–9.

Amponsah G, Antwi-Kusi A, Addison W, Abaidoo B. Medication errors among physician-assistants anaesthesia. Adv Anesthesiol. 2016; Article ID 9243587. https://doi.org/10.1155/2016/9243587

Amucheazi AO, Ajuzieogu OV. A retrospective audit of drug administration errors during elective surgery. Int J Anesthesiol. 2010; 25. http://ispub.com/IJA/25/1/10065. Accessed 18 Aug 2015.

Blignaut AJ, Coetzee SK, Klopper HC, Ellis SM. Medication administration errors and related deviations from safe practice: an observational study. J Clin Nurs. 2017;26(21–22):3610–23.

Gordon PC. Wrong drug administration errors amongst anaesthetists in a South African teaching hospital. South Afr J Anaesth Analg. 2004;10:7–8.

Gordon PC, Llewellyn RL, James MF. Drug administration errors by South African anaesthetists: a survey. S Afr Med J. 2006;96:630–2.

Feleke Y, Girma B. Medication administration errors involving paediatric in-patients in a hospital in Ethiopia. Trop J Pharm Res. 2010;9:401–7.

Feleke SA, Mulatu MA, Yesmaw YS. Medication administration error: magnitude and associated factors among nurses in Ethiopia. BMC Nurs. 2015;14:53.

Labuschagne M, Robbetze W, Rozmiarek J, Strydom M, Wentzel M, Diedericks BJS, Joubert G. Errors in drug administration by anaesthetists in public hospitals in the Free State. S Afr Med J. 2011;101:324–7.

Llewellyn RL, Gordon PC, Wheatcroft D, Lines D, Reed A, Butt AD, Lundgren AC, James MF. Drug administration errors: a prospective survey from three South African teaching hospitals. Anaesth Intensive Care. 2009;37:93–8.

Nwasor EO, Sule ST, Mshelia DB. Audit of medication errors by anesthetists in North Western Nigeria. Niger J Clin Pract. 2014;17:226–31.

Oshikoya KA, Oreagba IA, Ogunleye OO, Senbanjo IO, MacEbong GL, Olayemi SO. Medication administration errors among paediatric nurses in Lagos public hospitals: an opinion survey. Int J Risk Saf Med. 2013;25:67–78.

Agu KA, Oqua D, Adeyanju Z, Isah MA, Adesina A, Ohiaeri SI, Ali PN, Ekechukwu N, Akpakwu AA, Sani T, Omeh IO, King RC, Wutoh AK. The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings. PLoS One. 2014;9:e87338.

Hawaze S, Negash G, Kebede Y. Medication errors in the adult emergency unit of a tertiary care teaching hospital in Addis Ababa. Arch Pharm Pract. 2013;4:147–53.

Kandil M, Sayyed T, Emarh M, Ellakwa H, Masood A. Medication errors in the obstetrics emergency ward in a low resource setting. J Matern Fetal Neonatal Med. 2012;25:1379–82.

Ogunleye OO, Oreagba IA, Falade C, Isah A, Enwere O, Olayemi S, et al. Medication errors among health professionals in Nigeria: a national survey. Int J Risk Saf Med. 2016;28(2):77–91.

Sabry NA, Abbassi MM. Impact of a clinical pharmacist in the general hospital: an Egyptian trial. Pharmacol Pharm. 2014;5:577–87.

Sabry NA, Farid S, Aziz EOA. Role of the pharmacist in identification of medication related problems in the ICU: a preliminary screening study in an Egyptian teaching hospital. Aust J Basic Appl Sci. 2009;3:995–1003.

Shehata ZH, Sabri NA, Elmelegy AA. Descriptive analysis of medication errors reported to the Egyptian national online reporting system during six months. J Am Med Inform Assoc. 2016;23:366–74.

Benkirane RR, Abouqal R, Haimeur CC, Cherif El Kettani SS, Azzouzi AA, Mdaghri Alaoui AA, Thimou AA, Nejmi MM, Maazouzi WW, Madani NN, R-Edwards I, Soulaymani RR. Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study. J Patient Saf. 2009;5:16–22.

Dedefo MG, Mitike AH, Angamo MT. Incidence and determinants of medication errors and adverse drug events among hospitalized children in West Ethiopia. BMC Pediatr. 2016;16:81.

Jennane N, Madani N, Oulderrkhis R, Abidi K, Khoudri I, Belayachi J, Dendane T, Zeggwagh AA, Abouqal R. Incidence of medication errors in a Moroccan medical intensive care unit. Int Arch Med. 2011;4:32.

Begaud B, Evreux JC, Jouglard J, Lagier G. Imputation of the unexpected or toxic effects of drugs: actualization of the method used in France. Thérapie. 1985;40:111–8.

WHO Collaborating Center for International Drug Monitoring (UMC). Safety monitoring of medicinal products: guidelines for setting up and running a pharmacovigilance center. London: EQUUS; 2000. http://apps.who.int/medicinedocs/en/d/Jh2934e/. Accessed 10 Oct 2016.

Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm. 1992;27:538.

Trunet P, Le Gall JR, Lhoste F, Regnier B, Saillard Y, Carlet J, Rapin M. The role of iatrogenic disease in admissions to intensive care. JAMA. 1980;244:2617–20.

World Health Organization. The use of the WHO-UMC system for standardized case causality assessment. Uppsala: Uppsala Monitoring Center. http://who-umc.org/Graphics/24734.pdf. Accessed 10 Oct 2016.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–45.

US Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases. Division of AIDS (DAIDS) Table for Grading the Severity of Adult and Paediatric Adverse Events. 2004 clarification dated August 2009; Version 1.0, December 2004. http://rsc.tech-res.com/safetyandpharmacovigilance/gradingtables.aspx. Accessed 11 Nov 2017

Wilson RM, Runciman WB, Gibberd RW, Harrison BT, Newby L, Hamilton JD. The quality in Australian health care study. Med J Aust. 1995;163:458–76.

Edwards IR, Biriell C. Harmonization in pharmacovigilance. Drug Saf. 1994;10:93–102.

Temple ME, Robinson RF, Miller JC, Hayes JR, Nahata MC. Frequency and preventability of adverse drug reactions in paediatric patients. Drug Saf. 2004;27:819–29.

Jones JK. Adverse drug reactions in the community health setting: approaches to recognizing, counseling, and reporting. Fam Community Health. 1982;5:58–67.

Martínez-Mir I, García-López M, Palop V, Ferrer JM, Estañ L, Rubio E, Morales-Olivas FJ. A prospective study of adverse drug reactions as a cause of admission to a paediatric hospital. Br J Clin Pharmacol. 1996;42(3):319–24.

Schirm E, Tobi H, van Pulenbroek EP, Monster-Simons MH, de Jongvan den Berg LT. Reported adverse drug reactions and their determinants in Dutch children outside the hospital. Pharmacoepidemiol Drug Saf. 2004;13:159–65.

Nebeker JR, Barach P, Samore MH. Clarifying adverse drug events: a clinician’s guide to terminology, documentation, and reporting. Ann Intern Med. 2004;140:795–801.

Dormann H, Muth-Selbach U, Krebs S, Criegee-Rieck M, Tegeder I, Schneider HT, Hahn EG, Levy M, Brune K, Geisslinger G. Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting. Drug Saf. 2000;22:161–8.

Dornan T, Ashcroft D, Heathfield H, Lewis P, Miles J, Taylor D, Tully M, Wass V. An in-depth investigation into causes of prescribing errors by foundation trainees in relation to their medical education: EQUIP study. A report to the General Medical Council, 2009. http://www.gmc-uk.org/FINAL_Report_prevalence_and_causes-of_prescribing_errors.pdf-28935150.pdf. Accessed 10 Oct 2016.

Neville R, Roberts F, Livingstone S, Crombie I. A classification of prescription errors. JRCGP. 1989;39:110–2.

Chua SS, Chua HM, Omar A. Drug administration errors in paediatric wards: a direct observation approach. Eur J Pediatr. 2010;169:603–11.

Webster CS, Merry AF, Larsson L, McGrath KA, Weller J. The frequency and nature of drug administration error during anaesthesia. Anaesth Intensive Care. 2001;29:494–500.

Wheeler SJ, Wheeler DW. Medication errors in anaesthesia and critical care. Anaesthesia. 2005;60:257–73.

Juntti-Patinen L, Neuvonen PJ. Drug-related deaths in a university central hospital. Eur J Clin Pharmacol. 2002;58:479–82.

Davies EC, Green CF, Taylor S, Williamson PR, Mottram DR, Pirmohamed M. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One. 2009;4:e4439.

Alhawassi TM, Krass I, Bajorek BV, Pont LG. A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting. Clin Interv Aging. 2014;9:2079–86.

Hakkarainen KM, Hedna K, Petzold M, Hägg S. Percentage of patients with preventable adverse drug reactions and preventability of adverse drug reactions: a meta-analysis. PLoS One. 2012;7:e33236.

Leendertse AJ, Visser D, Egberts AC, van den Bemt PMLA. The relationship between study characteristics and the prevalence of medication-related hospitalizations. Drug Saf. 2010;33:233–44.

Agbabiaka T, Savović J, Ernst E. Methods for causality assessment of adverse drug reactions. Drug Saf. 2008;31:21–37.

Hakkarainen KM, Andersson Sundell K, Petzold M, Hagg S. Methods for assessing the preventability of adverse drug events: a systematic review. Drug Saf. 2012;35:105–26.

Dean Franklin B, Vincent C, Schachter M, Barber N. The incidence of prescribing errors in hospital inpatients: an overview of the research methods. Drug Saf. 2005;28:891–900.

Garfield S, Reynolds M, Dermont L, Franklin BD. Measuring the severity of prescribing errors: a systematic review. Drug Saf. 2013;36:1151–7.

Radley DC, Wasserman MR, Olsho LE, Shoemaker SJ, Spranca MD, Bradshaw B. Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems. J Am Med Inform Assoc. 2013;20:470–6.

Costello JL, Torowicz DL, Yeh TS. Effects of a pharmacist-led pediatrics medication safety team on medication-error reporting. Am J Health Syst Pharm. 2007;64:1422–6.

Mekonnen AB, McLachlan AJ, Brien JE. Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis. BMJ Open. 2016;6:e010003.

Mekonnen AB, McLachlan AJ, Brien JE. Pharmacy-led medication reconciliation programmes at hospital transitions: a systematic review and meta-analysis. J Clin Pharm Ther. 2016;41:128–44.

Tierney WM, Achieng M, Baker E, Bell A, Biondich P, Braitstein P, et al. Experience implementing electronic health records in three East African countries. Stud Health Technol Inform. 2010;160:371–5.

Mekonnen AB, Yesuf EA, Odegard PS, Wega SS. Implementing ward based clinical pharmacy services in an Ethiopian University Hospital. Pharm Pract. 2013;11:51–7.

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