Advances in biochemistry and the biotechnological production of taxifolin and its derivatives

Biotechnology and Applied Biochemistry - Tập 69 Số 2 - Trang 848-861 - 2022
Nguyễn Huy Thuần1, Anil Shrestha2, Nguyễn Thành Trung1, Vinay Bharadwaj Tatipamula1, Cuong V. Duong3, Nguyen Xuan Canh4, Nguyễn Văn Giảng4, Tae‐Su Kim5, Jae Kyung Sohng5, Dipesh Dhakal6
1Institute of Research and Development, Duy Tan University, Da Nang, Vietnam
2Combinatorial Biosynthesis National Research Laboratory, Ewha Womans University, Seoul, Republic of Korea
3Faculty of Biotechnology and Food Technology, Thainguyen University of Agriculture and Forestry, Thainguyen, Vietnam
4Faculty of Biotechnology, Vietnam National University of Agriculture, Gialam, Hanoi, Vietnam
5Department of Pharmaceutical Engineering and Biotechnology, SunMoon University, Asan-si, Chungnam, Republic of Korea
6Department of Medicinal Chemistry, University of Florida, Gainesville, Florida, USA

Tóm tắt

AbstractTaxifolin (dihydroquercetin) and its derivatives are medicinally important flavanonols with a wide distribution in plants. These compounds have been isolated from various plants, such as milk thistle, onions, french maritime, and tamarind. In general, they are commercially generated in semisynthetic forms. Taxifolin and related compounds are biosynthesized via the phenylpropanoid pathway, and most of the biosynthetic steps have been functionally characterized. The knowledge gained through the detailed investigation of their biosynthesis has provided the foundation for the reconstruction of biosynthetic pathways. Plant‐ and microbial‐based platforms are utilized for the expression of such pathways for generating taxifolin‐related compounds, either by whole‐cell biotransformation or through reconfiguration of the genetic circuits. In this review, we summarize recent advances in the biotechnological production of taxifolin and its derivatives.

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