Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review
Tóm tắt
Laryngeal rhabdomyosarcomas (RMSs) mainly occurred in children, while were extremely rare in adults. Consequently, less information was available to guide clinicians to manage adult RMSs in larynx.
A 42-year-old man presented with a 2-year history of gradually worsening hoarseness. Then, he underwent a surgery with suspension laryngoscope with initially being diagnosed as vocal cord cyst. Unexpectedly, the lesion was proved to be embryonal rhabdomyosarcoma (ERMS), pathologically. Next, he underwent chemoradiotherapy, while the tumor relapsed 18 months after the last treatment. Subsequently, a vertical hemilaryngectomy and a right selective neck dissection was performed, and the chemotherapy according to the anticancer drug sensitivity in vitro was arranged. Until the last check-up 18 months after chemotherapy, the patient did not display clinical or radiological signs of local recurrence and metastases.
Misdiagnosis and missed diagnosis of laryngeal RMSs might appear when tumors presented as smooth protuberance. We reported the first case of laryngeal RMSs in an adult with the multidisciplinary strategy based on the chemosensitivity assay in vitro. Furthermore, a systematic review of the literature was also discussed, highlighting the initial diagnostic pitfalls and subsequent management problems that may occur with this uncommon tumor.
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Tài liệu tham khảo
Mungan S, Arslan S, Küçüktülü E, Ersöz Ş, Çobanoğlu B. Pleomorphic Rhabdomyosarcoma arising from true vocal fold of larynx: report of a rare case and literature review. Case Rep Otolaryngol. 2016;2016:8135967.
Schrock A, Jakob M, Zhou H, Bootz F. Laryngeal pleomorphic rhabdomyosarcoma. Auris Nasus Larynx. 2007;34(4):553–6.
Pittore B, Fancello G, Cossu Rocca P, Ledda GP, Tore G. Rhabdomyosarcoma: a rare laryngeal neoplastic entity. Acta Otorhinolaryngol Ital. 2010;30(1):52–7.
Kukwa W, Wojtowicz P, Jagielska B, Sobczyk G, Kukwa A, Czarnecka AM. Laryngeal embryonal rhabdomyosarcoma in an adult - a case presentation in the eyes of geneticists and clinicians. BMC Cancer. 2011;11:166.
Diehn KW, Hyams VJ, Harris AE. Rhabdomyosarcoma of the larynx: a case report and review of the literature. Laryngoscope. 1984;94(2 Pt 1):201–5.
Chiramel GK, Chacko BR, Thomas R, Jebakumar D. A rare and unusual occurrence of rhabdomyosarcoma arising from the larynx. Indian J Cancer. 2015;52(1):125–6.
Li Y, Fu Z, Chen W, Yang L, Zhu W. Embryonal Rhabdomyosarcoma of the Adult's vocal cord: a case report. Iran Red Crescent Med J. 2015;17(8):e28876.
Russell JO, Revenaugh PC, Budd GT, Greskovich J, Scharpf J. Failed organ preservation strategy for adult laryngeal embryonal rhabdomyosarcoma. Am J Otolaryngol. 2015;36(2):277–9.
Leventhal DD, Spiegel J, Keane W. Laryngeal alveolar rhabdomyosarcoma involving the true vocal fold in an adult: case report. Ear Nose Throat J. 2010;89(12):E8.
Papacharalampous GX, Manolopoulos L, Korres S, Dicoglou C, Bibas A. Adult laryngeal rhabdomyosarcoma: is aggressive treatment justified in all cases? A case report and review of the literature. J Laryngol Otol. 2009;123(11):e21.
Dikbas O, Altundag K, Abali H, Turker A, Engin H, Sungur A, et al. Embryonal rhabdomyosarcoma of the larynx. Otolaryngol Head Neck Surg. 2005;133(1):160–2.
Libera DD, Falconieri G, Zanella M. Embryonal "Botryoid" rhabdomyosarcoma of the larynx: a clinicopathologic and immunohistochemical study of two cases. Ann Diagn Pathol. 1999;3(6):341–9.
Ruske DR, Glassford N, Costello S, Stewart IA. Laryngeal rhabdomyosarcoma in adults. J Laryngol Otol. 1998;112(7):670–2.
Akyol MU, Sözeri B, Küçükali T, Oğretmenoğlu O. Laryngeal pleomorphic rhabdomyosarcoma. Eur Arch Otorhinolaryngol. 1998;255(6):307–10.
Da Mosto MC, Marchiori C, Rinaldo A, Ferlito A. Laryngeal pleomorphic rhabdomyosarcoma. A critical review of the literature. Ann Otol Rhinol Laryngol. 1996;105(4):289–94.
Balázs M, Egerszegi P. Laryngeal botryoid rhabdomyosarcoma in an adult. Report of a case with electron microscopic study. Pathol Res Pract. 1989;184(6):643–9 discussion 649-51.
Haerr RW, Turalba CI, el-Mahdi AM, Brown KL. Alveolar rhabdomyosarcoma of the larynx: case report and literature review. Laryngoscope. 1987;97(3 Pt 1):339–44.
Srinivasan U, Talvalkar GV. True carcinosarcoma of the larynx: a case report. J Laryngol Otol. 1979;93(10):1031–5.
Winter LK, Lorentzen M. Rhabdomyosarcoma of the larynx. Report of two cases and a review of the literature. J Laryngol Otol. 1978;92(5):417–24.
Frugoni (Verona) P, Ferlito (Padua) A. Pleomorphic rhabdomyosarcoma of the larynx. A case report and review of the literature. J Laryngol Otol. 1976;90(7):687–98.
Cobanoglu B, Simsek M, Senol S. Rhabdomyosarcoma of the upper lip in an adult patient. Case Rep Med. 2015;2015:508051.
Newton WA Jr, Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, et al. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification--an intergroup Rhabdomyosarcoma study. Cancer. 1995;76(6):1073–85.
Knipe TA, Chandra RK, Bugg MF. Sclerosing rhabdomyosarcoma: a rare variant with predilection for the head and neck. Laryngoscope. 2005;115(1):48–50.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19(12):3091–102.
Crist W, Gehan EA, Ragab AH, Dickman PS, Donaldson SS, Fryer C, et al. The third intergroup Rhabdomyosarcoma study. J Clin Oncol. 1995;13(3):610–30.
Unger FT, Klasen HA, Tchartchian G, de Wilde RL, Witte I. DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells. BMC Cancer. 2009;9:359.
Isogai A, Nagaya M, Matsuoka H, Watanabe T, Tsukikawa S, Kubota S. An anticancer drug sensitivity test to determine the effectiveness of UFT as postoperative adjuvant chemotherapy for patients with stage III colorectal cancer. Surgery. 2007;142(5):741–8.
Wagemans J, Beuselinck B, Nuyts S, Sciot R, Delaere P, Vander Poorten V, et al. A case series of embryonal rhabdomyosarcoma of the head and neck in adults. Acta Clin Belg. 2010;65(6):404–10.
Hawkins WG, Hoos A, Antonescu CR, Urist MJ, Leung DH, Gold JS, et al. Clinicopathologic analysis of patients with adult rhabdomyosarcoma. Cancer. 2001;91(4):794–803.