Adrenocortical Carcinoma

Endocrine Reviews - Tập 35 Số 2 - Trang 282-326 - 2014
Tobias Else1,2, Alex C. Kim3, Aaron Sabolch4,2, Victoria M. Raymond1,2, Asha Kandathil4,3,2, Elaine M. Caoili4,3,2, Shruti Jolly4,2, Barbra S. Miller3, Thomas J. Giordano4,3,1,2, Gary D. Hammer1,2
1MEND/Division of Metabolism, Endocrinology, and Diabetes (T.E., T.J.G., G.D.H.), Division of Molecular Medicine and Genetics (V.M.R.), Department of Internal Medicine; University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109
2University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109
3Division of Endocrine Surgery (B.S.M.), Section of General Surgery, (A.C.K.), Department of Surgery, University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109
4Departments of Radiation Oncology (A.S., J.S.), Pathology (T.J.G.), and Radiology (A.K., E.M.C.); University of Michigan Hospital and Health Systems, Ann Arbor, Michigan 48109

Tóm tắt

AbstractAdrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable prognosis. Here we summarize the knowledge about diagnosis, epidemiology, pathophysiology, and therapy of ACC. Over recent years, multidisciplinary clinics have formed and the first international treatment trials have been conducted. This review focuses on evidence gained from recent basic science and clinical research and provides perspectives from the experience of a large multidisciplinary clinic dedicated to the care of patients with ACC.

Từ khóa


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