Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion
Tóm tắt
Từ khóa
Tài liệu tham khảo
Abercrombie, 1961, The bases of the locomotory behaviour of fibroblasts, Exp. Cell Res., 8, 188, 10.1016/0014-4827(61)90348-2
Anthis, 2011, The tail of integrin activation, Trends Biochem. Sci., 36, 191, 10.1016/j.tibs.2010.11.002
Anthis, 2009, The structure of an integrin/talin complex reveals the basis of inside-out signal transduction, Eur. Mol. Biol. Organ. J., 28, 3623, 10.1038/emboj.2009.287
Atherton, 2019, Force-independent interactions of talin and vinculin govern integrin-mediated mechanotransduction, bioRxiv, 10.1101/629683
Atherton, 2015, Vinculin controls talin engagement with the actomyosin machinery, Nat. Commun., 6, 1, 10.1038/ncomms10038
Austen, 2015, Extracellular rigidity sensing by talin isoform-specific mechanical linkages, Nat. Cell Biol., 17, 1597, 10.1038/ncb3268
Bachir, 2014, Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions, Curr. Biol., 24, 1, 10.1016/j.cub.2014.07.011
Bakolitsa, 2004, Structural basis for vinculin activation at sites of cell adhesion, Nature, 430, 583, 10.1038/nature02610
Banno, 2012, Subcellular localization of talin is regulated by inter-domain interactions, J. Biol. Chem., 287, 13799, 10.1074/jbc.M112.341214
Bate, 2012, Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics, PLoS ONE, 7, e34461, 10.1371/journal.pone.0034461
Bays, 2017, Vinculin in cell–cell and cell–matrix adhesions, Cell. Mol. Life Sci., 74, 2999, 10.1007/s00018-017-2511-3
Bishop, 1978, Genesis of a virus-transforming gene, Natl. Cancer Inst. Monogr., 48, 219
Brunet, 2017, The origin of animal multicellularity and cell differentiation, Dev. Cell, 43, 124, 10.1016/j.devcel.2017.09.016
Burridge, 1983, A new protein of adhesion plaques and ruffling membranes, J. Cell Biol., 97, 359, 10.1083/jcb.97.2.359
Calderwood, 2013, Talins and kindlins: partners in integrin-mediated adhesion, Nat. Rev. Mol. Cell Biol., 14, 503, 10.1038/nrm3624
Calderwood, 1999, The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation, J. Biol. Chem., 274, 28071, 10.1074/jbc.274.40.28071
Call, 2011, Zyxin phosphorylation at serine 142 modulates the zyxin head-tail interaction to alter cell-cell adhesion, Biochem. Biophys. Res. Commun, 404, 780, 10.1016/j.bbrc.2010.12.058
Campbell, 2011, Integrin structure, activation, and interactions, Cold Spring Harb. Perspect. Biol., 3, a004994, 10.1101/cshperspect.a004994
Carisey, 2013, Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner, Curr. Biol., 23, 271, 10.1016/j.cub.2013.01.009
Case, 2015, Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions, Nat. Cell Biol., 17, 880, 10.1038/ncb3180
Chan, 2010, Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK), J. Biol. Chem, 285, 11418, 10.1074/jbc.M109.090746
Chang, 2019, Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation, Proc. Natl. Acad. Sci. U.S.A., 116, 3524, 10.1073/pnas.1818880116
Chorev, 2018, Conformational states during vinculin unlocking differentially regulate focal adhesion properties, Sci. Rep., 8, 2693, 10.1038/s41598-018-21006-8
Cohen, 2005, Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin, J. Biol. Chem., 280, 17109, 10.1074/jbc.M414704200
Cohen, 2006, A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions, J. Biol. Chem., 281, 16006, 10.1074/jbc.M600738200
Cooper, 2003, Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction, Mol. Cell. Biol., 23, 8030, 10.1128/MCB.23.22.8030-8041.2003
Dedden, 2019, The Architecture of Talin1 reveals an autoinhibition mechanism, Cell, 179, 120, 10.1016/j.cell.2019.08.034
del Rio, 2009, Stretching single talin rod molecules activates vinculin binding, Science, 323, 638, 10.1126/science.1162912
DeMali, 2002, Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion, J. Cell Biol., 159, 881, 10.1083/jcb.200206043
Du, 1991, Ligands activate integrin αIIbβ3 (platelet GPIIb-IIIa), Cell, 65, 409, 10.1016/0092-8674(91)90458-B
Ellis, 2013, Talin autoinhibition is required for morphogenesis, Curr. Biol., 23, 1825, 10.1016/j.cub.2013.07.054
Franco, 2004, Calpain-mediated proteolysis of talin regulates adhesion dynamics, Nat. Cell Biol., 6, 977, 10.1038/ncb1175
Frelinger, 1990, Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers, J. Biol. Chem., 265, 6346, 10.1016/S0021-9258(19)39332-9
Frisch, 1996, Control of adhesion-dependent cell survival by focal adhesion kinase, J. Cell Biol., 134, 793, 10.1083/jcb.134.3.793
Geiger, 1979, A 130K protein from chicken gizzard: its localization at the termini of microfilament bundles in cultured chicken cells, Cell, 18, 193, 10.1016/0092-8674(79)90368-4
Gingras, 2008, The structure of the C-terminal actin-binding domain of talin, EMBO J., 27, 458, 10.1038/sj.emboj.7601965
Goksoy, 2008, Structural basis for the autoinhibition of Talin in regulating integrin activation, Mol. Cell, 31, 124, 10.1016/j.molcel.2008.06.011
Gough, 2018, The tale of two talins–two isoforms to fine-tune integrin signalling, FEBS Lett., 592, 2108, 10.1002/1873-3468.13081
Goult, 2009, The structure of an interdomain complex that regulates Talin activity, J. Biol. Chem., 284, 15097, 10.1074/jbc.M900078200
Goult, , Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation, J. Struct. Biol., 184, 21, 10.1016/j.jsb.2013.05.014
Goult, 2018, Talin as a mechanosensitive signaling hub, J. Cell Biol., 217, 3776, 10.1083/jcb.201808061
Goult, , RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover, J. Biol. Chem., 288, 8238, 10.1074/jbc.M112.438119
Gunawan, 2015, The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin, Nat. Immunol., 16, 505, 10.1038/ni.3125
Haage, 2018, Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo, Cell Rep., 25, 2401, 10.1016/j.celrep.2018.10.098
Han, 2006, Reconstructing and deconstructing agonist-induced activation of integrin αIIbβ3, Curr. Biol., 16, 1796, 10.1016/j.cub.2006.08.035
Han, 2019, Formation of talin-vinculin pre-complexes dictates maturation of nascent adhesions by accelerated force transmission and vinculin recruitment, bioRxiv, 735183, 10.1101/735183
Hemmings, 1996, Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site, J. Cell Sci., 109, 2715, 10.1242/jcs.109.11.2715
Horton, 2016, Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition, J. Cell Biol., 212, 349, 10.1083/jcb.201508080
Huang, 2018, Talin is a substrate for SUMOylation in migrating cancer cells, Exp. Cell Res., 370, 417, 10.1016/j.yexcr.2018.07.005
Humphries, 2007, Vinculin controls focal adhesion formation by direct interactions with talin and actin, J. Cell Biol., 179, 1043, 10.1083/jcb.200703036
Huveneers, 2009, Adhesion signaling–crosstalk between integrins, Src and Rho, J. Cell Sci., 122, 1059, 10.1242/jcs.039446
Huveneers, 2013, Mechanosensitive systems at the cadherin-F-actin interface, J. Cell Sci., 126, 403, 10.1242/jcs.109447
Hynes, 1992, Integrins: versatility, modulation, and signaling in cell adhesion, Cell, 69, 11, 10.1016/0092-8674(92)90115-S
Hytönen, 2008, How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism, PLoS Comput. Biol., 4, e24, 10.1371/journal.pcbi.0040024
Izard, 2004, Vinculin activation by talin through helical bundle conversion, Nature, 427, 171, 10.1038/nature02281
Johnson, 1995, F-actin binding site masked by the intramolecular association of vinculin head and tail domains, Nature, 373, 261, 10.1038/373261a0
Kanchanawong, 2010, Nanoscale architecture of integrin-based cell adhesions, Nature, 468, 580, 10.1038/nature09621
Kim, 2000, Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein, Nature, 404, 151, 10.1038/35004513
Kim, 2009, Interactions of platelet integrin α IIb and β 3 transmembrane domains in mammalian cell membranes and their role in integrin activation, Blood, 113, 4747, 10.1182/blood-2008-10-186551
Kim, 2003, Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins, Science, 301, 1720, 10.1126/science.1084174
Kim, 2008, Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration, J. Biol. Chem., 283, 32762, 10.1074/jbc.M800617200
Kioka, 1999, Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization, J. Cell Biol., 144, 58, 10.1083/jcb.144.1.59
Kopp, 2010, Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1, Eur. J. Cell Biol., 89, 661, 10.1016/j.ejcb.2010.05.003
Kumar, 2016, Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity, J. Cell Biol., 213, 371, 10.1083/jcb.201510012
Lad, 2007, Structure of three tandem filamin domains reveals auto-inhibition of ligand binding, EMBO J., 26, 3993, 10.1038/sj.emboj.7601827
Lagarrigue, 2015, A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration, Nat. Commun., 6, 8492, 10.1038/ncomms9492
Lau, 2009, The structure of the integrin αiIbB3 transmembrane complex explains integrin transmembrane signalling, EMBO J., 28, 1351, 10.1038/emboj.2009.63
Lee, 2013, Two modes of integrin activation form a binary molecular switch in adhesion maturation, Mol. Biol. Cell, 24, 1354, 10.1091/mbc.e12-09-0695
Lee, 2009, RIAM activates integrins by linking Talin to Ras GTPase membrane-targeting sequences, J. Biol. Chem., 284, 5119, 10.1074/jbc.M807117200
Lemke, 2019, A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo, PLOS Biol., 17, e3000057, 10.1371/journal.pbio.3000057
Li, 2017, Conformational equilibria and intrinsic affinities define integrin activation, EMBO J., 36, 629, 10.15252/embj.201695803
Lietha, 2007, Structural basis for the autoinhibition of focal adhesion kinase, Cell, 129, 1177, 10.1016/j.cell.2007.05.041
Lorenz, 1962, Deterministic nonperiodic flow, J. Atmos. Sci., 20, 130, 10.1175/1520-0469(1963)020<0130:DNF>2.0.CO;2
Luo, 2006, Integrin structures and conformational signaling, Curr. Opin. Cell Biol., 18, 579, 10.1016/j.ceb.2006.08.005
Maartens, 2016, Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes, J. Cell Sci., 129, 4354, 10.1242/jcs.189878
McCann, 1997, The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals, Proc. Natl. Acad. Sci. U.S.A., 94, 5679, 10.1073/pnas.94.11.5679
Molony, 1987, Properties of talin from chicken gizzard smooth muscle, J. Biol. Chem., 262, 7790, 10.1016/S0021-9258(18)47637-5
Moser, 2008, Kindlin-3 is essential for integrin activation and platelet aggregation, Nat. Med., 14, 325, 10.1038/nm1722
Mould, 1996, The inhibitory anti-β1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy, J. Biol. Chem., 271, 20365, 10.1074/jbc.271.34.20365
Nix, 2001, Targeting of zyxin to sites of actin membrane interaction and to the nucleus, J. Biol. Chem., 276, 34759, 10.1074/jbc.M102820200
Orré, 2019, The inner life of integrin adhesion sites: from single molecules to functional macromolecular complexes, Exp. Cell Res., 379, 235, 10.1016/j.yexcr.2019.03.036
Papagrigoriou, 2004, Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle, EMBO J., 23, 2942, 10.1038/sj.emboj.7600285
Pawson, 1992, SH2 and SH3 domains: from structure to function, Cell, 71, 359, 10.1016/0092-8674(92)90504-6
Peng, 2010, Vinculin regulates cell-surface E-cadherin expression by binding to β-catenin, J. Cell Sci., 123, 567, 10.1242/jcs.056432
Pufall, 2002, Autoinhibitory domains: modular effectors of cellular regulation, Annu. Rev. Cell Dev. Biol, 18, 421, 10.1146/annurev.cellbio.18.031502.133614
Qin, 2004, Integrin bidirectional signaling: a molecular view, PLoS Biol., 2, e169, 10.1371/journal.pbio.0020169
Ribeiro, 2014, The structure and regulation of human muscle α-Actinin, Cell, 159, 1447, 10.1016/j.cell.2014.10.056
Ringer, 2017, Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1, Nat. Methods, 14, 1090, 10.1038/nmeth.4431
Rogalski, 2000, The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane, J. Cell Biol., 150, 253, 10.1083/jcb.150.1.253
Rossier, 2016, The journey of integrins and partners in a complex interactions landscape studied by super-resolution microscopy and single protein tracking, Exp. Cell Res., 343, 28, 10.1016/j.yexcr.2015.11.004
Rossier, 2012, Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions, Nat. Cell Biol., 14, 1057, 10.1038/ncb2588
Saltel, 2009, New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering, J. Cell Biol., 187, 715, 10.1083/jcb.200908134
Saxena, 2017, Force-induced calpain cleavage of Talin is critical for growth, adhesion development, and rigidity sensing, Nano Lett., 17, 7242, 10.1021/acs.nanolett.7b02476
Schlaepfer, 1999, Signaling through focal adhesion kinase, Prog. Biophys. Mol. Biol., 71, 435, 10.1016/S0079-6107(98)00052-2
Sebé-Pedrós, 2010, Ancient origin of the integrin-mediated adhesion and signaling machinery, Proc. Natl. Acad. Sci. U.S.A., 107, 10142, 10.1073/pnas.1002257107
Senetar, 2005, Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin, Gene, 362, 141, 10.1016/j.gene.2005.08.012
Shattil, 2010, The final steps of integrin activation: the end game, Nat. Rev. Mol. Cell Biol., 11, 288, 10.1038/nrm2871
Shenoy, 1992, Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis, Proc. Natl. Acad. Sci. U.S.A., 89, 7237, 10.1073/pnas.89.15.7237
Shimaoka, 2002, Conformational regulation of integrin structure and function, Annu. Rev. Biophys. Biomol. Struct., 31, 485, 10.1146/annurev.biophys.31.101101.140922
Song, 2012, A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion, Cell Res., 22, 1533, 10.1038/cr.2012.97
Spiess, 2018, Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions, J. Cell Biol., 217, 1929, 10.1083/jcb.201707075
Srivastava, 2008, Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling, Proc. Natl. Acad. Sci. U.S.A., 105, 14436, 10.1073/pnas.0805163105
Stefanini, 2016, RAP1-GTPase signaling and platelet function, J. Mol. Med., 94, 13, 10.1007/s00109-015-1346-3
Takeya, 2008, The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells, EMBO J., 27, 618, 10.1038/emboj.2008.7
Tamkun, 1986, Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin, Cell, 46, 271, 10.1016/0092-8674(86)90744-0
Vinogradova, 2002, A structural mechanism of integrin αIIbβ3 inside-out activation as regulated by its cytoplasmic face, Cell, 110, 587, 10.1016/S0092-8674(02)00906-6
Wachsstock, 1987, Specific interaction of vinculin with α-actinin, Biochem. Biophys. Res. Commun., 146, 554, 10.1016/0006-291X(87)90564-X
Wegener, 2007, Structural basis of integrin activation by Talin, Cell, 128, 171, 10.1016/j.cell.2006.10.048
Winograd-Katz, 2014, The integrin adhesome: from genes and proteins to human disease, Nat. Rev. Mol. Cell Biol., 15, 273, 10.1038/nrm3769
Yao, , Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation, Sci. Rep., 4, 4610, 10.1038/srep04610
Yao, , Force-dependent conformational switch of α-catenin controls vinculin binding, Nat. Commun., 5, 4525, 10.1038/ncomms5525
Young, 2000, The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism, EMBO J., 19, 6331, 10.1093/emboj/19.23.6331
Yutin, 2008, The deep archaeal roots of eukaryotes, Mol. Biol. Evol., 25, 1619, 10.1093/molbev/msn108
Zhang, 2012, Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion, J. Cell Biol., 197, 819, 10.1083/jcb.201112129
Zhang, 2014, The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism, J. Mol. Cell Biol., 6, 128, 10.1093/jmcb/mjt044
Zhao, 2011, Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis, Adv. Drug Deliv. Rev., 63, 610, 10.1016/j.addr.2010.11.001