Acute downregulation of miR-155 leads to a reduced collagen synthesis through attenuating macrophages inflammatory factor secretion by targeting SHIP1

Artlett CM, Sassi-Gaha S, Hope JL, Feghali-Bostwick CA, Katsikis PD (2017) Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis. Arthritis Res Ther 19:144

Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, Mizel DE, Anzano M, Teresa GW, Wahl SM, Deng C, Roberts AB (1999) Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1:260–266

Asirvatham AJ, Gregorie CJ, Hu Z, Magner WJ, Tomasi TB (2008) MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immuno 145:1995–2006

Bloemen MC, Veer WM, Ulrich MM, Zuijlen PP, Niessen FB, Petri A, Frederiksen KS (2009) Prevention and curative management of hypertrophic scar formation. Burns 35:463–475

Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG (2008) Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 173:57–67

Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:655–657

Christmann RB, Wooten A, Sampaio-Barros P, Borges CL, Carvalho CR, Kairalla RA, Feghali-Bostwick C, Ziemek J, Mei Y, Goummih S, Tan J, Alvarez D, Kass DJ, Rojas M, Mattos TL, Parra E, Stifano G, Capelozzi VL, Simms RW, Lafyatis R (2016) miR-155 in the progression of lung fibrosis in systemic sclerosis. Arthritis Res Ther 18:155

Conte E, Fruciano M, Fagone E (2011) Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms. PLoS ONE 6:e24663

Dovi JV, He LK, Luisa A (2003) Accelerated wound closure in neutrophil depleted mice. J Leukoc Biol 3:448–455

Evans RA, Tian YC, Steadman R, Phillips AO, Petri A, Frederiksen KS (2003) TGF-beta1 mediated fibroblast myofibroblast terminal differentiation the role of Smad proteins. Exp Cell Res 282:90–100

Ferguson MW, Kane S (2004) Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans Biol Sci 359:839–850

Godwin JW, Brockes JP (2006) Regeneration, tissue injury and the immune response. J Anat 209:423–432

Graves DT, Nooh N, Gillen T, Davey M, Patel S, Cottrell D, Amar S (2001) IL-1 plays a critical role in oral, but not dermal, wound healing. J Immunol 167:5316–5320

Harty M, Neff AW, King MW, Mescher AL (2003) Regeneration or scarring: an immunologic perspective. Dev Dyn 226:268–279

Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127:526–537

Jennifer R, Arlette DM, Hang TN (2013) Role of microRNAs in the immune system, inflammation and cancer. World J Gastroenterol 19:2985–2996

Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M (2005) Silencing of microRNAs in vivo with ‘antagomirs’. Nature 438:685–689

Laskin DL, Pendino KJ (1995) Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 35:655–677

Leibovich SJ, Ross R (1975) The role of the macrophage in wound repair: A study with hydrocortisone and anti-macrophage serum. J Pathol 78:71–100

Li HY, Zhang QG, Chen JW (2013) The fibrotic role of PI3K/Akt pathway in injured skeletal muscle after acute contusion. Int J Sports Med 34:789–794

Li Y, Zhang J, Zhang W, Liu Y, Li Y, Wang K, Zhang Y, Yang C, Li X, Shi J, Su L, Hu D (2017) MicroRNA-192 regulates hypertrophic scar fibrosis by targeting SIP1. J Mol Histol 48:357–366

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:769–773

Martin P, Leibovich SJ (2005) Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol 15:599–607

Matsui F, Meldrum KK, Asirvatham AJ (2012) The role of the Janus kinase family/signal transducer and activator of transcription signaling pathway in fibrotic renal disease. J Surg Res 178:339–345

Montgomery RL, Yu G, Latimer PA, Stack C, Robinson K, Ferguson MW, Kane S, Asirvatham AJ (2014) MicroRNA mimicry blocks pulmonary fibrosis. EMBO Mol Med 6:1347–1356

O’Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (2007) MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci 104:1604–1609

O’Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL (2010) MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33:607–619

Pandit KV, Milosevic J (2015) MicroRNA regulatory networks in idiopathic pulmonary fibrosis. Biochem Cell Biol 11:1–9

Paterno J, Vial IN, Wong VW (2011) Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation. Wound Repair Regen 19:49–58

Pottier N, Maurin T, Chevalier B, Puissegur MP, Lebrigand K (2009) Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial mesenchymal interactions. PLoS ONE 4:e6718

Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR (2007) Requirement of bic/microRNA-155 for normal immune function. Science 316:608–611

Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A (2011) Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair Regen 19(Suppl. 1):s10–s15

Sideek MA, Teia A, Kopecki Z, Cowin AJ, Gibson MA (2016) Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar. J Mol Histol 47:35–45

Sonkoly E, Stahle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18:131–140

Tili E, Croce CM, Michaille JJ (2009) miR-155: on the crosstalk between inflammation and cancer. Int Rev Immuno 128:264–284

Worm J, Stenvang J, Petri A, Frederiksen KS, Obad S (2009) Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res 37:5784–5792

Yang LL, Liu JQ, Bai XZ, Fan L, Han F, Jia WB, Su LL, Shi JH, Tang CW, Hu DH (2014) Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response. Biochem Biophys Res Commun 453:153–159

Yang L, Zheng Z, Zhou Q, Bai X, Fan L, Yang C, Su L, Hu D (2017) miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2. J Mol Histol 48:147–155