Acute cataract in the rat after exposure to radiation in the 300 nm wavelength region A study of the macro‐, micro‐ and ultrastructure

Acta Ophthalmologica - Tập 66 Số 2 - Trang 141-152 - 1988
PG SÖDERBERG1
1Department of Medical Biophysics and Department of Ophthalmology, Karolinska Institutet, Stockholm, Sweden, and Department of Environmental Optometry, College of Optometry, University of Houston, Texas, USA

Tóm tắt

AbstractExperimental and epidemiological data indicate a correlation between exposure to UV radiation and cataract morbidity. UV radiation induced cataract is thought to be evoked by photochemical mechanisms. The present investigation resolves the macroscopical events in the rat lens after a one dose exposure to spectrally and radiometrically well defined UV radiation, as revealed in light‐ and dark‐field illumination. The macroscopic sequence of events is related to the morphology as revealed by light‐ and electron microscopy. The radiation was found to alter the chromatin pattern and to induce morphological changes indicating a disturbance of the cellular water balance. The latter is assumed to cause the acute UV radiation induced opacification of the lens. It is suggested that future investigations of the toxic effects of UV radiation in the lens should focus on how UV radiation affects the chromatin and the cellular water balance.

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Acta Ophthalmologica

Tập 66 Số 2

141-152

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