Acute Erythroleukaemia in a Patient treated with Melphalan for the Cold Agglutinin Syndrome

Wiley - Tập 8 Số 5 - Trang 375-379 - 1971
P Stavem1, M Harboe2
1Section of Haematology (Chief, P. F. Hjort), Medical Department A, Rikshospitalet, Oslo
2Section of Immunology (Chief, M. Harboe), Institute for Experimental Medical Research, University of Oslo, Ullevål Hospital, Oslo, Norway

Tóm tắt

In a case of cold agglutinin syndrome, treatment with melphalan resulted in marked decrease of cold agglutinin titre, decrease in concentration of monoclonal cold agglutinin IgM, and concomitant clinical improvement with increased cold tolerance. After 27 months of melphalan treatment, the patient developed acute erythroleukaemia.

Từ khóa


Tài liệu tham khảo

Alexanian A., 1970, Leukemia – Lymphoma., 392

10.1111/j.1600-0609.1970.tb01888.x

10.1111/j.1365-2141.1970.tb01635.x

Editorial, 1971, Leukaemia and cytotoxic drugs., Lancet, 70

10.1084/jem.106.5.689

10.1111/j.1600-0609.1964.tb00019.x

10.1111/j.1600-0609.1969.tb01836.x

10.1084/jem.129.6.1217

Hippe E., 1970, Chlorambucil treatment of patients with cold agglutinin syndrome, Blood, 35, 68, 10.1182/blood.V35.1.68.68

10.1056/NEJM197011192832111

10.1056/NEJM197011192832101

Schubothe H., 1966, The cold hemagglutinin disease, Sent. Hemat., 3, 27

Schubothe H., 1961, Makroglobulinvermehrung und lymphoide Zellproliferation bei der chronischen Kälteagglutininkrankheit, Schw. med. Wschr., 91, 1154