Activity of continuous-infusion 5-fluorouracil in patients with advanced colorectal cancer clinically resistant to bolus 5-fluorouracil

Cancer Chemotherapy and Pharmacology - Tập 33 Số 2 - Trang 179-180 - 1993
A. Mori1, Sergio Bertoglio1, Alessandra Guglielmi1, C. Aschele1, E. Bolli1, Lucia Tixi1, Riccardo Rosso1, Alberto F. Sobrero1
1Istituto Nazionale per la Ricerca Sul Cancro, Genova, Italy

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Tài liệu tham khảo

Aschele C, Sobrero A, Faderan MA, Bertino JR (1992) Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 52: 1855?1864

Izzo J, Zarba J, Rougier P (1992) Low dose 5-FU continuous infusion (FU CI) in advanced colorectal cancer (ACC): clinical evidence for reversal for acquired/intrinsic resistance to 5-FU or 5-FU folinic acid (FUFO) (abstract 1298). Proc Am Assoc Cancer Res 33: 217

Leichman CG, Leichman L, Spears CP, Rosen P, Jeffers S, Groshen S (1993) Prolonged continuous infusion of fluorouracil with weekly bolus leucovorin: a phase II study in patients with disseminated colorectal cancer. J Natl Cancer Inst 85: 41?44

Lokich JJ, Ahlgren JD, Gullo JJ (1989) A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program study. J Clin Oncol 7: 425?432

Shaekney SE (1985) Cell kinetics and cancer chemotherapy. In: Calabresi P, Shein PS, Rosenberg SA (eds) Medical oncology. MacMillan, New York, pp 41?60

Sobrero A, Rosso R, Aschele C, Guglielmi A, Mori A, Bertoglio S, Tixi L, Bolli E, Bertino JR (1993) Sequential bolus and continuous infusion 5-fluorouracil: experimental and clinical studies (abstract 667). Proc Am Soc Clin Oncol 12: 219