Activin-Binding Protein from Rat Ovary Is Follistatin

American Association for the Advancement of Science (AAAS) - Tập 247 Số 4944 - Trang 836-838 - 1990
Takanori Nakamura1, Koji Takio1, Yuzuru Eto2, Hiroshiro Shibai2, Koiti Titani1,3, Hiromu Sugino1
1Frontier Research Program, Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, Japan
2Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki-ku, Kawasaki 210, Japan
3Fujita-Gakuen Health UniversitNr, Toyoake, Aichi, 470-11, Japan

Tóm tắt

Activin, a member of the transforming growth factor β protein family, was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone (FSH). Activin has numerous functions in both normal and neoplastic cells. Various cells synthesize activin and have a specific binding site for this peptide. However, the molecular basis for its actions is unknown. A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin.

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Tài liệu tham khảo

CAMPEN, C.A., CHARACTERIZATION OF ACTIVIN-A BINDING-SITES ON THE HUMAN-LEUKEMIA CELL-LINE K562, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 157: 844 (1988).

ESCH, F.S., COMPLEMENTARY DEOXYRIBONUCLEIC-ACID (CDNA) CLONING AND DNA-SEQUENCE ANALYSIS OF RAT OVARIAN INHIBINS, MOLECULAR ENDOCRINOLOGY 1: 388 (1987).

ESCH, F.S., STRUCTURAL CHARACTERIZATION OF FOLLISTATIN - A NOVEL FOLLICLE-STIMULATING-HORMONE RELEASE-INHIBITING POLYPEPTIDE FROM THE GONAD, MOLECULAR ENDOCRINOLOGY 1: 849 (1987).

ETO, Y, PURIFICATION AND CHARACTERIZATION OF ERYTHROID-DIFFERENTIATION FACTOR (EDF) ISOLATED FROM HUMAN-LEUKEMIA CELL-LINE THP-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 142: 1095 (1987).

FORAGE, R.G., CLONING AND SEQUENCE-ANALYSIS OF CDNA SPECIES CODING FOR THE 2 SUBUNITS OF INHIBIN FROM BOVINE FOLLICULAR-FLUID, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 3091 (1986).

FUKUDA, M, ISOLATION OF BOVINE FOLLICULAR-FLUID INHIBIN OF ABOUT 32-KDA, MOLECULAR AND CELLULAR ENDOCRINOLOGY 44: 55 (1986).

HASEGAWA, Y, INDUCTION OF FOLLICLE-STIMULATING HORMONE RECEPTOR BY ERYTHROID-DIFFERENTIATION FACTOR ON RAT GRANULOSA-CELL, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 156: 668 (1988).

HINO, M, CHARACTERIZATION OF CELLULAR RECEPTORS FOR ERYTHROID-DIFFERENTIATION FACTOR ON MURINE ERYTHROLEUKEMIA-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 10309 (1989).

HUTCHINSON, L.A., EFFECTS OF BOVINE INHIBIN, TRANSFORMING GROWTH-FACTOR-BETA AND BOVINE ACTIVIN-A ON GRANULOSA-CELL DIFFERENTIATION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 146: 1405 (1987).

KITAOKA, M, ACTIVIN-A - A MODULATOR OF MULTIPLE TYPES OF ANTERIOR-PITUITARY CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 157: 48 (1988).

KONDO, S, IDENTIFICATION OF THE 2 TYPES OF SPECIFIC RECEPTOR FOR ACTIVIN/EDF EXPRESSED ON FRIEND-LEUKEMIA AND EMBRYONAL CARCINOMA-CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 161: 1267 (1989).

10.1038/227680a0

LEVERSHA, L.J., ISOLATION OF INHIBIN FROM OVINE FOLLICULAR-FLUID, JOURNAL OF ENDOCRINOLOGY 113: 213 (1987).

LING, N, PITUITARY FSH IS RELEASED BY A HETERODIMER OF THE BETA-SUBUNITS FROM THE 2 FORMS OF INHIBIN, NATURE 321: 779 (1986).

LING, N, ISOLATION AND PARTIAL CHARACTERIZATION OF A MR 32,000 PROTEIN WITH INHIBIN ACTIVITY FROM PORCINE FOLLICULAR-FLUID, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 7217 (1985).

MASON, A.J., STRUCTURE OF 2 HUMAN OVARIAN INHIBINS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 135: 957 (1986).

MASON, A.J., COMPLEMENTARY-DNA SEQUENCES OF OVARIAN FOLLICULAR-FLUID INHIBIN SHOW PRECURSOR STRUCTURE AND HOMOLOGY WITH TRANSFORMING GROWTH FACTOR-BETA, NATURE 318: 659 (1985).

MATSUDAIRA, P, SEQUENCE FROM PICOMOLE QUANTITIES OF PROTEINS ELECTROBLOTTED ONTO POLYVINYLIDENE DIFLUORIDE MEMBRANES, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 10035 (1987).

MAYO, K.E., INHIBIN A-SUBUNIT CDNAS FROM PORCINE OVARY AND HUMAN-PLACENTA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 5849 (1986).

MIYAMOTO, K, ISOLATION OF PORCINE FOLLICULAR-FLUID INHIBIN OF 32K DALTONS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 129: 396 (1985).

MURATA, M, EXPRESSION OF ERYTHROID-DIFFERENTIATION FACTOR (EDF) IN CHINESE-HAMSTER OVARY CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 151: 230 (1988).

MURATA, M, ERYTHROID-DIFFERENTIATION FACTOR IS ENCODED BY THE SAME MESSENGER-RNA AS THAT OF THE INHIBIN BETA-A CHAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 2434 (1988).

NAKAMURA T unpublished data.

RIVIER, J, PURIFICATION AND PARTIAL CHARACTERIZATION OF INHIBIN FROM PORCINE FOLLICULAR-FLUID, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 133: 120 (1985).

ROBERTSON, D.M., ISOLATION OF INHIBIN FROM BOVINE FOLLICULAR-FLUID, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 126: 220 (1985).

ROBERTSON, D.M., THE ISOLATION OF POLYPEPTIDES WITH FSH SUPPRESSING ACTIVITY FROM BOVINE FOLLICULAR-FLUID WHICH ARE STRUCTURALLY DIFFERENT TO INHIBIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 149: 744 (1987).

ROBERTSON, D.M., ISOLATION OF A 31 KDA FORM OF INHIBIN FROM BOVINE FOLLICULAR-FLUID, MOLECULAR AND CELLULAR ENDOCRINOLOGY 44: 271 (1986).

SHIMASAKI, S, FOLLISTATIN GENE-EXPRESSION IN THE OVARY AND EXTRAGONADAL TISSUES, MOLECULAR ENDOCRINOLOGY 3: 651 (1989).

SHIMASAKI, S, PRIMARY STRUCTURE OF THE HUMAN FOLLISTATIN PRECURSOR AND ITS GENOMIC ORGANIZATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 4218 (1988).

STEWART, A.G., HUMAN INHIBIN GENES - GENOMIC CHARACTERIZATION AND SEQUENCING, FEBS LETTERS 206: 329 (1986).

SUGINO, H, ERYTHROID-DIFFERENTIATION FACTOR CAN MODULATE FOLLICULAR GRANULOSA-CELL FUNCTIONS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 153: 281 (1988).

SUGINO, H, IDENTIFICATION OF A SPECIFIC RECEPTOR FOR ERYTHROID-DIFFERENTIATION FACTOR ON FOLLICULAR GRANULOSA-CELL, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 15249 (1988).

TOTSUKA, Y, A NOVEL ACTION OF ACTIVIN-A - STIMULATION OF INSULIN-SECRETION IN RAT PANCREATIC-ISLETS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 156: 335 (1988).

UENO, N, ISOLATION AND PARTIAL CHARACTERIZATION OF FOLLISTATIN - A SINGLE-CHAIN MR 35,000 MONOMERIC PROTEIN THAT INHIBITS THE RELEASE OF FOLLICLE-STIMULATING-HORMONE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 8282 (1987).

VALE, W, PURIFICATION AND CHARACTERIZATION OF AN FSH RELEASING PROTEIN FROM PORCINE OVARIAN FOLLICULAR-FLUID, NATURE 321: 776 (1986).

YING, S.Y., FOLLISTATIN SPECIFICALLY INHIBITS PITUITARY FOLLICLE-STIMULATING HORMONE-RELEASE INVITRO, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 149: 133 (1987).

YU, J, IMPORTANCE OF FSH-RELEASING PROTEIN AND INHIBIN IN ERYTHRODIFFERENTIATION, NATURE 330: 765 (1987).