Activation of the vitamin D receptor transcription factor stimulates the growth of definitive erythroid progenitors

Blood Advances - Tập 2 - Trang 1207-1219 - 2018
Jeffrey Barminko1,2, Brad M. Reinholt1,2, Alexander Emmanuelli1,2, Alannah N. Lejeune1,2, Margaret H. Baron1,2,3,4,5
1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
2The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
3Department of Cellular, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY
4Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
5The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Tóm tắt

Key Points

Activation of the Vdr pathway stimulates proliferation of early, but not late, mouse erythroid progenitors in a cell autonomous manner. Vdr and Gr signaling cooperate to increase the growth of mouse erythroid progenitors.


Tài liệu tham khảo

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