Activation of BDNF signaling prevents the return of fear in female mice

Learning and Memory - Tập 20 Số 5 - Trang 237-240 - 2013
Danay Baker‐Andresen1, Charlotte R. Flavell1, Xiang Li1, Timothy W. Bredy1
1Psychiatric Epigenomics Laboratory, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia

Tóm tắt

There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of Bdnf exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal.

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Learning and Memory

Tập 20 Số 5

237-240

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