Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer

Cairns, 2011, Regulation of cancer cell metabolism, Nat. Rev. Cancer, 11, 85, 10.1038/nrc2981

Warburg, 1956, On the origin of cancer cells, Science, 123, 309, 10.1126/science.123.3191.309

Smith, 2016, Addiction to coupling of the warburg effect with glutamine catabolism in cancer cells, Cell Rep., 17, 821, 10.1016/j.celrep.2016.09.045

Kruiswijk, 2015, p53 in survival, death and metabolic health: a lifeguard with a licence to kill, Nat. Rev. Mol. Cell Biol., 16, 393, 10.1038/nrm4007

Vousden, 2009, p53 and metabolism, Nat. Rev. Cancer, 9, 691, 10.1038/nrc2715

Tang, 2008, Acetylation is indispensable for p53 activation, Cell, 133, 612, 10.1016/j.cell.2008.03.025

Brooks, 2003, Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation, Curr. Opin. Cell Biol., 15, 164, 10.1016/S0955-0674(03)00003-6

Sykes, 2006, Acetylation of the p53 DNA-binding domain regulates apoptosis induction, Mol. Cell, 24, 841, 10.1016/j.molcel.2006.11.026

Tang, 2006, Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis, Mol. Cell, 24, 827, 10.1016/j.molcel.2006.11.021

Pandey, 2015, TIP60-miR-22 axis as a prognostic marker of breast cancer progression, Oncotarget, 6, 41290, 10.18632/oncotarget.5636

Zhang, 2016, TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program, J. Mol. Cell Biol., 10.1093/jmcb/mjw038

Bassi, 2016, The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair, Cell Death Differ., 23, 1198, 10.1038/cdd.2015.173

Chen, 2012, Role of Tip60 in human melanoma cell migration, metastasis, and patient survival, J. Investig. Dermatol., 132, 2632, 10.1038/jid.2012.193

Gorrini, 2007, Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response, Nature, 448, 1063, 10.1038/nature06055

Squatrito, 2006, Tip60 in DNA damage response and growth control: many tricks in one HAT, Trends Cell Biol., 16, 433, 10.1016/j.tcb.2006.07.007

Ikura, 2000, Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis, Cell, 102, 463, 10.1016/S0092-8674(00)00051-9

Kusch, 2004, Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions, Science, 306, 2084, 10.1126/science.1103455

Sun, 2005, A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM, Proc. Natl. Acad. Sci. USA, 102, 13182, 10.1073/pnas.0504211102

Murr, 2006, Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks, Nat. Cell Biol., 8, 91, 10.1038/ncb1343

Kaidi, 2013, KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling, Nature, 498, 70, 10.1038/nature12201

Charvet, 2011, Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53, Mol. Cell, 42, 584, 10.1016/j.molcel.2011.03.033

Zheng, 2013, A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence, Mol. Cell, 50, 699, 10.1016/j.molcel.2013.04.013

Lin, 2012, GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy, Science, 336, 477, 10.1126/science.1217032

Creaven, 1999, Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein Tat, Biochemistry, 38, 8826, 10.1021/bi9907274

Yang, 2012, Function of the active site lysine autoacetylation in Tip60 catalysis, PLoS One, 7, e32886, 10.1371/journal.pone.0032886

Wang, 2010, SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60, J. Biol. Chem., 285, 11458, 10.1074/jbc.M109.087585

Yi, 2014, Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3, J. Biol. Chem., 289, 33878, 10.1074/jbc.M114.575266

Li, 2010, The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis, Proc. Natl. Acad. Sci. USA, 107, 14188, 10.1073/pnas.1005960107

Sun, 2009, Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60, Nat. Cell Biol., 11, 1376, 10.1038/ncb1982

Doyon, 2004, Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans, Mol. Cell Biol., 24, 1884, 10.1128/MCB.24.5.1884-1896.2004

Knutson, 2011, Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes, Mol. Cell Biol., 31, 818, 10.1128/MCB.00687-10

Tyteca, 2006, Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression, EMBO J., 25, 1680, 10.1038/sj.emboj.7601066

Jha, 2008, Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage, Mol. Cell Biol., 28, 2690, 10.1128/MCB.01983-07

Penicud, 2014, DMAP1 is an essential regulator of ATM activity and function, Oncogene, 33, 525, 10.1038/onc.2012.597

Yang, 2008, Lysine acetylation: codified crosstalk with other posttranslational modifications, Mol. Cell, 31, 449, 10.1016/j.molcel.2008.07.002

Peng, 2012, SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60, Mol. Cell Biol., 32, 2823, 10.1128/MCB.00496-12

Legube, 2002, Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation, EMBO J., 21, 1704, 10.1093/emboj/21.7.1704

Wang, 2016, Analysis of TRRAP as a potential molecular marker and therapeutic target for breast cancer, J. Breast Cancer, 19, 61, 10.4048/jbc.2016.19.1.61

Macher-Goeppinger, 2013, Senescence-associated protein p400 is a prognostic marker in renal cell carcinoma, Oncol. Rep., 30, 2245, 10.3892/or.2013.2698

Yamaguchi, 2014, Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway, Eur. J. Cancer, 50, 1555, 10.1016/j.ejca.2014.01.023

Spedale, 2012, ATAC-king the complexity of SAGA during evolution, Genes Dev., 26, 527, 10.1101/gad.184705.111