About Stress Hormones and Resilience to Psychopathology

Journal of Neuroendocrinology - Tập 20 Số 6 - Trang 885-892 - 2008
E. R. de Kloet1
1Division of Medical Pharmacology, LACDR/LUMC, Leiden, The Netherlands

Tóm tắt

Neuroendocrinology links experience and behaviour to the action of hormones. This review focusses on the corticosteroids, released in hourly pulses and after stress, to illustrate the integration of body, brain and mind achieved by these hormones. Corticosteroids coordinate cell and organ function in concert with other mediators of the stress response over time spans from seconds to hours, days, weeks, or even permanently. The actions exerted by these stress hormones are mediated by two receptor types that control initial stress reactions and manage the later adaptive phases. How the balance between the stress and adaptive responses contributes to resilience and health is a conundrum to be resolved during the next two decades of the existence of the Journal of Neuroendocrinology.

Từ khóa


Tài liệu tham khảo

De Knecht‐van Eekelen A, 1993, Hoofdlijnen van het endocrinologisch onderzoek in Nederland na 1947

10.1146/annurev.pharmtox.44.101802.121410

10.1038/87936

10.1098/rspb.1952.0011

10.1113/jphysiol.1970.sp009115

Clarke IJ, 2002, Two decades of measuring GnRH secretion, Reprod Suppl, 59, 1

Wade N, 1981, The Nobel Duel; Two Scientists’ 21‐year Race to Win the World’s Most Coveted Research Prize, 1

10.1146/annurev.neuro.20.1.533

10.1006/frne.1996.0148

10.1016/0018-506X(91)90020-I

10.1006/hbeh.1999.1548

10.2174/187152706776359664

10.1016/j.yfrne.2003.07.001

10.1210/endo.140.9.7001

10.1016/j.tins.2007.10.005

Reichstein T, 1936, Eine wirksame kristallinische Substanz aus der Rinde der Nebenniere, Corticosterone, Proc Kon Akad Wetensch, 39, 1218

10.1038/138032a0

10.1038/sj.bjp.0706456

10.1126/science.86.2228.245

10.1210/er.21.1.55

Tausk M, 1952, Hat die Nebennieren Rinde wirklich einen Verteidigungs Funktion?, Das Horm, 3

10.1126/science.3037703

10.1038/220911a0

10.1210/endo-96-3-598

10.1016/j.pnpbp.2005.03.014

10.1210/en.2005-0501

10.1016/j.neuron.2007.11.017

10.1210/endo-117-6-2505

10.1210/er.19.3.269

10.1016/S0140-6736(88)90742-8

10.1126/science.2845584

10.1126/science.2781292

10.1073/pnas.87.12.4495

10.1016/j.tips.2006.03.007

10.1073/pnas.0507572102

10.1523/JNEUROSCI.23-12-04850.2003

Olijslagers JE, Rapid pre‐ and postsynaptic effects via membrane mineralocorticoid receptors increase excitability in the hippocampal CA1 area, Eur J Neurosci

10.1101/lm.87706

10.1155/2007/93202

10.1016/j.yfrne.2004.07.001

10.1210/en.2007-0585

10.1037/0735-7044.106.1.62

10.1016/j.tics.2006.02.002

10.1523/JNEUROSCI.1187-07.2007

10.1037/0735-7044.118.5.1062

10.1016/j.yfrne.2005.08.001

10.1196/annals.1366.002

10.1210/en.2007-1234

10.1016/S0306-4530(99)00058-X

10.1016/S0166-2236(99)01438-1

10.1126/science.287.5451.248

10.1073/pnas.231313998

10.1210/jc.87.8.3798

10.1016/0024-3205(81)90090-4

10.1016/S0014-2999(01)01586-2

10.1016/j.yfrne.2007.04.001

10.1016/S0893-133X(00)00159-7

Nemeroff CB, 2005, The neurobiology of depression: inroads to treatment and new drug discovery, J Clin Psychiatry, 66, 5

10.1038/nrn1683

10.1016/j.metabol.2005.01.008

10.1056/NEJMra012941

10.1038/ng1479

10.1017/CBO9780511544422

10.1016/0022-3956(85)90068-8

10.1038/sj.npp.1300884

10.1016/j.tem.2006.02.006

10.1038/sj.npp.1301170

Ising M, 2006, Genetics of stress response and stress‐related disorders, Dialogues Clin Neurosci, 8, 433, 10.31887/DCNS.2006.8.4/mising

10.1038/ncpendmet0403

10.1210/rp.59.1.333

10.1210/jc.2006-0915

10.1038/sj.npp.1301260

10.1016/j.psyneuen.2005.03.013

10.1126/science.277.5332.1659

10.1046/j.1460-9568.2000.00231.x

10.1523/JNEUROSCI.18-23-10171.1998

10.1530/eje.0.151U049

10.1073/pnas.0506571103

10.1016/j.yfrne.2005.10.002

10.1038/nn1733

10.1073/pnas.94.25.14002

10.1073/pnas.211427898

10.1523/JNEUROSCI.22-15-06810.2002

10.1038/nrn1555

10.1016/j.biopsych.2006.02.013

10.1111/j.1460-9568.2007.05972.x

10.1016/j.brainresbull.2004.08.006

10.1038/nn1668

10.1016/S0197-4580(02)00017-9

Champagne DL, Maternal care and hippocampal plasticity: evidence for experience‐dependent structural plasticity, altered synaptic functioning and differential responsiveness to glucocorticoids and stress, J Neurosci

10.1038/sj.npp.1301544

10.1016/j.ejphar.2007.11.070

10.1073/pnas.0503878102

10.1073/pnas.0606067104

10.1111/j.1460-9568.2007.05427.x

Van Hooijdonk LWA, Functional effects of RNAi mediated glucocorticoid receptor knockdown in the mouse brain, 6th Dutch Endo-Neuro-Psycho Meeting

10.1210/me.2007-0233

Vreugdenhil E, Tissue specific microRNA’s affect glucocorticoid receptor activity, Keystone Symposium: ‘RNAi, microRNA and non-coding RNA’

10.1101/lm.435807

10.1016/S0018-506X(02)00024-7