Abnormal thalamic volume in treatment‐naïve boys with Tourette syndrome

Acta Psychiatrica Scandinavica - Tập 113 Số 1 - Trang 64-67 - 2006
J.‐S. Lee1, Seung-Schik Yoo2, S.‐Y. Cho1, Sun Myeong Ock3, Myung Kwan Lim4, Charles R.G. Guttmann2
1Department of Psychiatry, Inha University Hospital and College of Medicine, Incheon, South Korea
2Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA
3Department of Family Medicine, Catholic University Medical College, Uijongbu
4Department of Radiology, Inha University Hospital and College of Medicine, Incheon, South Korea

Tóm tắt

Objective:  Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment‐naïve boys with TS using magnetic resonance imaging (MRI).Method:  Volumetric MRI was performed on 18 treatment‐naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume.Results:  Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects.Conclusion:  Our findings provide new evidence of abnormal thalamic volume in pediatric TS.

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Thông tin xuất bản

Acta Psychiatrica Scandinavica

Tập 113 Số 1

64-67

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