Các tế bào gốc mỡ từ bệnh nhân bị bỏng có xu hướng tăng cường chuyển hóa oxy hóa và sản xuất loài phản ứng oxy trong quá trình tái sinh
Tóm tắt
Bệnh nhân có tổn thương bỏng nghiêm trọng (trên 20% diện tích bề mặt cơ thể) trải qua tình trạng chuyển hóa cao, điều này làm kéo dài đáng kể thời gian lành vết thương. Các tế bào gốc lấy từ mỡ (ASCs) đã được đề xuất như một giải pháp hấp dẫn cho việc điều trị vết thương bỏng, bao gồm khả năng mở rộng tự thân của ASCs. Trong khi các tế bào mỡ dưới da thể hiện một hồ sơ chuyển hóa thay đổi sau khi bị bỏng, vẫn chưa biết liệu điều này có xảy ra với các tế bào gốc liên quan đến mô mỡ hay không.
Các ASCs được tách ra từ da bỏng thải loại của các bệnh nhân bị thương nặng (BH,
Không có sự khác biệt về độ tuổi giữa BH và UH (34 ± 6 và 41 ± 4 tuổi, tương ứng,
Như vậy, các ASCs từ những người bị bỏng có xu hướng ngày càng trở nên oxy hóa nhiều hơn và ít glycolytic hơn khi so với các ASCs từ bệnh nhân chưa bị bỏng. Sự gia tăng khả năng oxy hóa này có liên quan đến sản xuất ROS ở các lần cấy ghép sau. Mặc dù việc mở rộng tự thân của ASCs có triển vọng lớn cho việc điều trị các bệnh nhân bị bỏng với nguồn tế bào donor hạn chế, những hệ quả tiêu cực tiềm ẩn khi sử dụng chúng cần được nghiên cứu thêm.
Từ khóa
Tài liệu tham khảo
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