A unifying principle underlying the extracellular field potential spectral responses in the human cortex

Journal of Neurophysiology - Tập 114 Số 1 - Trang 505-519 - 2015
Ella Podvalny1,2, Niv Noy1,2, Michal Harel1, Stephan Bickel3,4, Gal Chechik2, Charles E. Schroeder5,6, Ashesh D. Mehta4, Misha Tsodyks1, Rafael Malach1
1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
2Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
3Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York
4Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine and Feinstein Institute for Medical Research, Manhasset, New York;
5Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York; and
6Department of Psychiatry, Columbia College of Physicians and Surgeons, New York, New York

Tóm tắt

Electrophysiological mass potentials show complex spectral changes upon neuronal activation. However, it is unknown to what extent these complex band-limited changes are interrelated or, alternatively, reflect separate neuronal processes. To address this question, intracranial electrocorticograms (ECoG) responses were recorded in patients engaged in visuomotor tasks. We found that in the 10- to 100-Hz frequency range there was a significant reduction in the exponent χ of the 1/ fχ component of the spectrum associated with neuronal activation. In a minority of electrodes showing particularly high activations the exponent reduction was associated with specific band-limited power modulations: emergence of a high gamma (80–100 Hz) and a decrease in the alpha (9–12 Hz) peaks. Importantly, the peaks' height was correlated with the 1/ fχ exponent on activation. Control simulation ruled out the possibility that the change in 1/ fχ exponent was a consequence of the analysis procedure. These results reveal a new global, cross-frequency (10–100 Hz) neuronal process reflected in a significant reduction of the power spectrum slope of the ECoG signal.

Từ khóa


Tài liệu tham khảo

10.1073/pnas.92.19.8616

10.1017/CBO9780511574566

10.1523/JNEUROSCI.21-05-01676.2001

10.1103/PhysRevLett.59.381

10.1016/j.bpj.2008.12.3951

10.1016/S0006-3495(04)74250-2

10.1523/JNEUROSCI.0009-08.2008

10.1007/BF01797193

10.1371/journal.pcbi.1000519

10.1126/science.1099745

10.1093/acprof:oso/9780195301069.001.0001

Chatrian GE, 1976, Handbook of Electroencephalography Clinical Neurophysiology: The EEG in the Waking Adult, 46

10.1038/nn.2501

10.1016/S1388-2457(00)00545-9

10.1093/brain/121.12.2301

10.1093/brain/121.12.2271

10.1038/nrn2961

10.1007/s10827-010-0263-2

10.1038/nature06028

10.1007/BF00202899

10.1016/j.neuron.2009.11.001

10.1007/s11571-008-9064-y

10.1126/science.1055465

10.1073/pnas.86.5.1698

10.1038/nature06563

10.1016/j.neuron.2010.04.020

10.1016/j.tics.2014.04.003

10.1152/jn.00919.2004

10.1007/s10548-014-0379-1

10.1523/JNEUROSCI.1687-12.2013

10.1046/j.1460-9568.2000.00163.x

10.1016/j.neuron.2007.07.027

10.1523/JNEUROSCI.2041-09.2009

10.1109/TBME.2008.918569

10.1371/journal.pcbi.1000609

10.1371/journal.pone.0004338

10.3758/BF03206543

10.1016/S0896-6273(03)00200-9

10.1146/annurev-psych-120709-145401

10.1126/science.1110913

10.1016/j.cub.2007.06.066

10.1038/nn.2177

10.1523/JNEUROSCI.6048-11.2012

10.1523/JNEUROSCI.1275-09.2009

10.1016/S0304-3940(98)00435-2

10.1016/0013-4694(77)90235-8

10.3109/00207459208999796

10.1523/JNEUROSCI.4627-06.2007

10.1523/JNEUROSCI.0877-12.2012

10.1523/JNEUROSCI.4217-12.2013

10.1523/JNEUROSCI.0656-12.2012

10.1523/JNEUROSCI.2929-08.2008

Talairach J, 1988, Co-Planar Stereotaxic Atlas of the Human Brain

10.1038/nature13159

10.1109/PROC.1982.12433

10.1016/j.chaos.2011.12.019

10.1523/JNEUROSCI.5644-11.2012

10.1016/0167-2789(93)90083-D

Thông tin
Thông tin xuất bản

Journal of Neurophysiology

Tập 114 Số 1

505-519

Thông tin tác giả