A systematic review of prevalence studies of depression in Parkinson's disease

Movement Disorders - Tập 23 Số 2 - Trang 183-189 - 2008
Jennifer Reijnders1, Uwe Ehrt2, Waylon Weber3, Dag Aarsland4,2, Albert F.G. Leentjens1
1Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands
2Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
3Department of neurology, Maastricht University Hospital, Maastricht, The Netherlands
4School of Medicine, University of Bergen, Bergen, Norway

Tóm tắt

AbstractPrevalence rates of depressive disorders in Parkinson's disease (PD) vary widely across studies, ranging from 2.7% to more than 90%. The aim of this systematic review was to calculate average prevalences of depressive disorders taking into account the different settings and different diagnostic approaches of studies. Using Medline on Pubmed, a systematic literature search was carried out for studies of depression in Parkinson's disease. A total of 104 articles were included and assessed for quality; 51 articles fulfilled the quality criteria. Multiple publications from the same database were not included in the meta‐analysis. In the remaining 36 articles, the weighted prevalence of major depressive disorder was 17% of PD patients, that of minor depression 22% and dysthymia 13%. Clinically significant depressive symptoms, irrespective of the presence of a DSM defined depressive disorder, were present in 35%. In studies using a (semi) structured interview to establish DSM criteria, the reported prevalence of major depressive disorder was 19%, while in studies using DSM criteria without a structured interview, the reported prevalence of major depressive disorder was 7%. Population studies report lower prevalence rates for both major depressive disorder and the clinically significant depressive symptoms than studies in other settings. This systematic review suggests that the average prevalence of major depressive disorder in PD is substantial, but lower than generally assumed. © 2007 Movement Disorder Society

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Movement Disorders

Tập 23 Số 2

183-189

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