A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients

Human Molecular Genetics - Tập 20 Số 23 - Trang 4556-4568 - 2011
Paola Griseri1,2, Christine Bourcier2, Corinne Hiéblot3, Khadija Essafi‐Benkhadir4, Emmanuel Chamorey5, Christian Touriol3, Gilles Pagès2
1Laboratory of Molecular Genetics, Institute Giannina Gaslini, Genoa, Italy
2University Nice-Sophia Antipolis Institute of Developmental Biology and Cancer, CNRS UMR 6543 and
3INSERM UMR 1037, CRTC (Centre de recherche en cancérologie de Toulouse), Equipe 5 Université Paul Sabatier Toulouse III, CHU Rangueil, Bât. L3 B.P. 84225 31432 TOULOUSE CEDEX 4, France and
4Biochemistry and Experimental Pathology Unit, Pasteur Institute of Tunis, Tunis, Tunisia and
5Statistics Department, Centre Antoine Lacassagne, Nice, France,

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Tài liệu tham khảo

Eberhardt, 2007, Modulation of mRNA stability as a novel therapeutic approach, Pharmacol. Ther., 114, 56, 10.1016/j.pharmthera.2007.01.002

Carrick, 2004, The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis, Arthritis Res. Ther., 6, 248, 10.1186/ar1441

Cao, 2004, Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein, J. Biol. Chem., 279, 21489, 10.1074/jbc.M400900200

Brook, 2006, Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways, Mol. Cell. Biol., 26, 2408, 10.1128/MCB.26.6.2408-2418.2006

Essafi-Benkhadir, 2007, Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation, Mol. Biol. Cell, 18, 4648, 10.1091/mbc.E07-06-0570

Sandler, 2008, Control of mRNA decay by phosphorylation of tristetraprolin, Biochem. Soc. Trans., 36, 491, 10.1042/BST0360491

Taylor, 1996, A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency, Immunity, 4, 445, 10.1016/S1074-7613(00)80411-2

Carballo, 1997, Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (−/−) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction, J. Clin. Invest., 100, 986, 10.1172/JCI119649

Carballo, 2000, Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability, Blood, 95, 1891, 10.1182/blood.V95.6.1891

Sawaoka, 2003, Tristetraprolin binds to the 3′-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site, J. Biol. Chem., 278, 13928, 10.1074/jbc.M300016200

Datta, 2008, Tristetraprolin regulates CXCL1 (KC) mRNA stability, J. Immunol., 180, 2545, 10.4049/jimmunol.180.4.2545

Suswam, 2008, Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells, Cancer Res., 68, 674, 10.1158/0008-5472.CAN-07-2751

Kim, 2010, Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia, Biochem. Biophys. Res. Commun., 391, 963, 10.1016/j.bbrc.2009.11.174

Brennan, 2009, The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis, Cancer Res., 69, 5168, 10.1158/0008-5472.CAN-08-4238

Al-Souhibani, 2010, The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes, Oncogene, 29, 4205, 10.1038/onc.2010.168

Lee, 2010, Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer, Int. J. Cancer, 126, 1817, 10.1002/ijc.24847

Kamangar, 2006, Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world, J. Clin. Oncol., 24, 2137, 10.1200/JCO.2005.05.2308

Mahtani, 2001, Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability, Mol. Cell. Biol., 21, 6461, 10.1128/MCB.21.9.6461-6469.2001

Bourcier, 2011, Constitutive ERK activity induces down-regulation of Tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells, Am. J. Physiol. Cell Physiol., 301, 609, 10.1152/ajpcell.00506.2010

Lai, 1999, Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA, Mol. Cell. Biol., 19, 4311, 10.1128/MCB.19.6.4311

Hall, 2009, Current perspective - trastuzumab, Eur. J. Cancer., 45, 12, 10.1016/j.ejca.2008.10.013

Sauna, 2007, Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer, Cancer Res., 67, 9609, 10.1158/0008-5472.CAN-07-2377

Marderosian, 2006, Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling, Oncogene, 25, 6277, 10.1038/sj.onc.1209645

Lee, 2010, Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin, J. Biol. Chem., 285, 17329, 10.1074/jbc.M109.094235

Casey, 2009, Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer, Breast Cancer Res. Treat., 114, 47, 10.1007/s10549-008-9982-8

Richardson, 2006, X chromosomal abnormalities in basal-like human breast cancer, Cancer Cell., 9, 121, 10.1016/j.ccr.2006.01.013

Carrick, 2006, Genetic variations in ZFP36 and their possible relationship to autoimmune diseases, J. Autoimmun., 26, 182, 10.1016/j.jaut.2006.01.004

Comeron, 2004, Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence, Genetics, 167, 1293, 10.1534/genetics.104.026351

Nackley, 2006, Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure, Science, 314, 1930, 10.1126/science.1131262

Duan, 2003, Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor, Hum. Mol. Genet., 12, 205, 10.1093/hmg/ddg055

Kimchi-Sarfaty, 2007, A silent polymorphism in the MDR1 gene changes substrate specificity, Science, 315, 525, 10.1126/science.1135308

Raponi, 2010, Alternative splicing: good and bad effects of translationally silent substitutions, FEBS J., 277, 836, 10.1111/j.1742-4658.2009.07519.x

Czech, 2010, Silent mutations in sight: co-variations in tRNA abundance as a key to unravel consequences of silent mutations, Mol. Biosyst., 6, 1767, 10.1039/c004796c

Tsai, 2008, Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima, J. Mol. Biol., 383, 281, 10.1016/j.jmb.2008.08.012

Tuller, 2010, Translation efficiency is determined by both codon bias and folding energy, Proc. Natl Acad. Sci. USA, 107, 3645, 10.1073/pnas.0909910107

Bornes, 2004, Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences, J. Biol. Chem., 279, 18717, 10.1074/jbc.M308410200

Schmittgen, 2008, Analyzing real-time PCR data by the comparative C(T) method, Nat. Protoc., 3, 1101, 10.1038/nprot.2008.73

Eckert, 2004, Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis, Cancer Res., 64, 4585, 10.1158/0008-5472.CAN-04-0396

Bastide, 2008, An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform, Nucleic Acids Res., 36, 2434, 10.1093/nar/gkn093

Beauclair, 2007, Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity, Ann. Oncol., 18, 1335, 10.1093/annonc/mdm181