A statistical model for cryo electron microscope images and 3-D reconstruction and experimental design [spherical viruses]

Zhye Yin1, Yili Zheng1, P.C. Doerschuk1
1School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, USA

Tóm tắt

A statistical model for cryo electron microscope images is described. 3-D reconstruction and experimental design methods based on the model are demonstrated. Advantages of this approach to 3-D reconstruction include that minimal prior information, only particle symmetry and radii, is required.

Từ khóa

#Electron microscopy #Three dimensional displays #Design for experiments #Viruses (medical) #Image reconstruction #Particle scattering #Fourier transforms #Design engineering #Signal reconstruction #Proteins

Tài liệu tham khảo

lehmann, 1998, Theory of Point Estimation 10.1063/1.1698233 zheng, 2002, Parallel implementations of 3-D reconstruction algorithms for cryo electron microscopy: A comparative study 0 yin, 2003, 3-D reconstruction from projections of unknown orientation and cryo electron microscopy applications 10.1109/78.218151 10.1109/18.59929 10.1137/S0036141098341770 van trees, 1968, Detection Estimation and Modulation Theory Pa r t I 10.1109/18.857786