A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment

Translational Psychiatry - Tập 3 Số 1 - Trang e209-e209
Shilpa Ravinder1, Nesha S. Burghardt2, RA Brodsky3, Erwin Bauer3, Sumantra Chattarji1
1National Centre for Biological Sciences - Tata Institute of Fundamental Research, Bangalore, India
2Departments of Neuroscience, Psychiatry & Pharmacology, Columbia University, New York, USA
3Biology Department, Barnard College, Columbia University, New York, USA

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Kent JM, Coplan JD, Gorman JM . Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety. Biol Psychiatry 1998; 44: 812–824.

Sheehan DV, Raj BA, Trehan RR, Knapp EL . Serotonin in panic disorder and social phobia. Int Clin Psychopharmacol 1993; 8: 63–77.

van der Kolk BA, Dreyfuss D, Michaels M, Shera D, Berkowitz R, Fisler R et al. Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry 1994; 55: 517–522.

Gorman JM . Treating generalized anxiety disorder. J Clin Psychiatry 2003; 64: 24–29.

Gorman JM, Liebowitz MR, Fyer AJ, Goetz D, Campeas RB, Fyer MR et al. An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharmacol 1987; 7: 329–332.

Teicher MH, Glod C, Cole JO . Emergence of intense suicidal preoccupation during fluoxetine treatment. Am J Psychiatry 1990; 147: 207–210.

Mir S, Taylor D . The adverse effects of antidepressants. Curr Opin Psychitary 1997; 10: 88–94.

Spigset O . Adverse reactions of selective serotonin reuptake inhibitors—Reports from a spontaneous reporting system. Drug Saf 1999; 20: 277–287.

Fergusson D, Doucette S, Cranley K, Glass KC, Shapiro S, Healy D et al. Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. Br Med J 2005; 330: 396–399.

Masand PS, Gupta S . Selective serotonin-reuptake inhibitors: an update. Harv Rev Psychiatry 1999; 7: 69–84.

Ravinder S, Pillai AG, Chattarji S . Cellular correlates of enhanced anxiety caused by acute treatment with the selective serotonin reuptake inhibitor fluoxetine in rats. Front Behav Neurosci 2011; 5: 88.

Griebel G, Moreau JL, Jenck F, Misslin R, Martin JR . Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents. Psychopharmacology (Berl) 1994; 113: 463–470.

Sanchez C, Meier E . Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression—Are they all alike? Psychopharmacology (Berl) 1997; 129: 197–205.

Dekeyne A, Denorme B, Monneyron S, Millan MJ . Citalopram reduces social interaction in rats by activation of serotonin (5-HT)(2C) receptors. Neuropharmacology 2000; 39: 1114–1117.

Salchner P, Singewald N . Neuroanatomical substrates involved in the anxiogenic-like effect of acute fluoxetine treatment. Neuropharmacology 2002; 43: 1238–1248.

Burghardt NS, Sullivan GM, McEwen BS, Gorman JM, LeDoux JE . The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: A comparison with tianeptine. Biol Psychiatry 2004; 55: 1171–1178.

LeDoux JE . Emotion circuits in the brain. Annu Rev Neurosci 2000; 23: 155–184.

Sah P, Faber ES, Lopez De Armentia M, Power J . The amygdaloid complex: anatomy and physiology. Physiol Rev 2003; 83: 803–834.

Ehrlich I, Humeau Y, Grenier F, Ciocchi S, Herry C, Luthi A . Amygdala inhibitory circuits and the control of fear memory. Neuron 2009; 62: 757–771.

Maren S, Quirk GJ . Neuronal signalling of fear memory. Nat Rev Neurosci 2004; 5: 844–852.

McDonald AJ . Cortical pathways to the mammalian amygdala. Prog Neurobiol 1998; 55: 257–332.

Turner BH, Herkenham M . Thalamoamygdaloid projections in the rat: a test of the amygdala's role in sensory processing. J Comp Neurol 1991; 313: 295–325.

LeDoux JE, Iwata J, Cicchetti P, Reis DJ . Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J Neurosci 1988; 8: 2517–2529.

Petrovich GD, Swanson LW . Projections from the lateral part of the central amygdalar nucleus to the postulated fear conditioning circuit. Brain Res 1997; 763: 247–254.

Duvarci S, Popa D, Pare D . Central amygdala activity during fear conditioning. J Neurosci 2011; 31: 289–294.

Walker DL, Toufexis DJ, Davis M . Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 2003; 463: 199–216.

Ploski JE, Pierre VJ, Smucny J, Park K, Monsey MS, Overeem KA et al. The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala. J Neurosci 2008; 28: 12383–12395.

Burghardt NS, Bush DEA, McEwen BS, LeDoux JE . Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT2C receptor antagonist. Biol Psychiatry 2007; 62: 1111–1118.

Bodnoff SR, Suranyi-Cadotte B, Quirion R, Meaney MJ . A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety. Psychopharmacology (Berl) 1989; 97: 277–279.

Silva RCB, Brandao ML . Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacol Biochem Behav 2000; 65: 209–216.

Paxinos G, Watson C . The Rat Brain in Stereotaxic Coordinates. Academic Press, Elsevier Inc.: San Diego, USA, 2009.

Garrigou D, Broekkamp CL, Lloyd KG . Involvement of the amygdala in the effect of antidepressants on the passive avoidance deficit in bulbectomised rats. Psychopharmacology (Berl) 1981; 74: 66–70.

Lee EH, Lin WR, Chen HY, Shiu WH, Liang KC . Fluoxetine and 8-OH-DPAT in the lateral septum enhances and impairs retention of an inhibitory avoidance response in rats. Physiol Behav 1992; 51: 681–688.

Mamiya N, Fukushima H, Suzuki A, Matsuyama Z, Homma S, Frankland PW et al. Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory. J Neurosci 2009; 29: 402–413.

Pandey SC, Zhang H, Ugale R, Prakash A, Xu T, Misra K . Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. J Neurosci 2008; 28: 2589–2600.

Ramirez-Amaya V, Vazdarjanova A, Mikhael D, Rosi S, Worley PF, Barnes CA . Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J Neurosci 2005; 25: 1761–1768.

Guzowski JF, Timlin JA, Roysam B, McNaughton BL, Worley PF, Barnes CA . Mapping behaviorally relevant neural circuits with immediate-early gene expression. Curr Opin Neurobiol 2005; 15: 599–606.

Montag-Sallaz M, Montag D . Learning-induced arg 3.1/arc mRNA expression in the mouse brain. Learn Mem 2003; 10: 99–107.

de Olmos JS, Heimer L . The concepts of the ventral striatopallidal system and extended amygdala. Ann NY Acad Sci 1999; 877: 1–32.

Grillon C . Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology (Berl) 2008; 199: 421–437.

Hammack SE, Guo JD, Hazra R, Dabrowska J, Myers KM, Rainnie DG . The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 1309–1320.

Davis M, Walker DL, Miles L, Grillon C . Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 2010; 35: 105–135.

Inoue T, Hashimoto S, Tsuchiya K, Izumi T, Ohmori T, Koyama T . Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur J Pharmacol 1996; 311: 1–6.

Hashimoto S, Inoue T, Koyama T . Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats. Psychopharmacology (Berl) 1996; 123: 182–186.

Phillips RG, LeDoux JE . Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 1992; 106: 274–285.

Rudy JW . Contextual conditioning and auditory cue conditioning dissociate during development. Behav Neurosci 1993; 107: 887–891.

Malberg JE, Eisch AJ, Nestler EJ, Duman RS . Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20: 9104–9110.

Rainnie DG . Neurons of the bed nucleus of the stria terminalis (BNST): electrophysiological properties and their response to serotonin. Ann N Y Acad Sci 1999; 877: 695–699.

Pare D, Quirk GJ, Ledoux JE . New vistas on amygdala networks in conditioned fear. J Neurophysiol 2004; 92: 1–9.

Davis M . The role of the amygdala in fear and anxiety. Annu Rev Neurosci 1992; 15: 353–375.

Roozendaal B, McEwen BS, Chattarji S . Stress, memory and the amygdala. Nat Rev Neurosci 2009; 10: 423–433.

Anand A, Shekhar A . Brain imaging studies in mood and anxiety disorders. Ann NY Acad Sci 2003; 985: 370–388.

Drevets WC . Neuroimaging abnormalities in the amygdala in mood disorders. Ann NY Acad Sci 2003; 985: 420–444.

Rauch SL, Shin LM, Wright CI . Neuroimaging studies of amygdala function in anxiety disorders. Ann NY Acad Sci 2003; 985: 389–410.

Hasler G, Northoff G . Discovering imaging endophenotypes for major depression. Mol Psychiatry 2011; 16: 604–619.

Del-Ben CM, Deakin JFW, McKie S, Delvai NA, Williams SR, Elliott R et al. The effect of citalopram pretreatment on neuronal responses to neuropsychological tasks in normal volunteers: an fMRI study. Neuropsychopharmacology 2005; 30: 1724–1734.

McKie S, Del-Ben C, Elliott R, Williams S, del Vai N, Anderson I et al. Neuronal effects of acute citalopram detected by pharmacoMRI. Psychopharmacology (Berl) 2005; 180: 680–686.

Grillon C, Levenson J, Pine DS . A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study. Neuropsychopharmacology 2007; 32: 225–231.

Shepherd JD, Bear MF . New views of Arc, a master regulator of synaptic plasticity. Nat Neurosci 2011; 14: 279–284.

Bramham CR, Worley PF, Moore MJ, Guzowski JF . The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci 2008; 28: 11760–11767.

Steward O, Worley PF . A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc Natl Acad Sci USA 2001; 98: 7062–7068.

Bauer EP, Schafe GE, LeDoux JE . NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci 2002; 22: 5239–5249.

Rodrigues SM, Schafe GE, LeDoux JE . Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. J Neurosci 2001; 21: 6889–6896.

Veening JG, Coolen LM, Spooren WJ, Joosten H, van Oorschot R, Mos J et al. Patterns of c-fos expression induced by fluvoxamine are different after acute vs chronic oral administration. Eur Neuropsychopharmacol 1998; 8: 213–226.

Lino-de-Oliveira C, Sales AJ, Del Bel EA, Silveira MC, Guimaraes FS . Effects of acute and chronic fluoxetine treatments on restraint stress-induced Fos expression. Brain Res Bull 2001; 55: 747–754.

Izumi T, Inoue T, Kitaichi Y, Nakagawa S, Koyama T . Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor. Eur J Pharmacol 2006; 534: 129–132.

Zanoveli JM, Carvalho MC, Cunha JM, Brandao ML . Extracellular serotonin level in the basolateral nucleus of the amygdala and dorsal periaqueductal gray under unconditioned and conditioned fear states: an in vivo microdialysis study. Brain Res 2009; 1294: 106–115.

Yokoyama M, Suzuki E, Sato T, Maruta S, Watanabe S, Miyaoka H . Amygdalic levels of dopamine and serotonin rise upon exposure to conditioned fear stress without elevation of glutamate. Neurosci Lett 2005; 379: 37–41.

Yoshioka M, Matsumoto M, Togashi H, Saito H . Effects of conditioned fear stress on 5-HT release in the rat prefrontal cortex. Pharmacol Biochem Behav 1995; 51: 515–519.

Goosens KA, Maren S . Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear. Behav Neurosci 2003; 117: 738–750.

Wilensky AE, Schafe GE, Kristensen MP, LeDoux JE . Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J Neurosci 2006; 26: 12387–12396.

Rabinak CA, Maren S . Associative structure of fear memory after basolateral amygdala lesions in rats. Behav Neurosci 2008; 122: 1284–1294.

Zimmerman JM, Rabinak CA, McLachlan IG, Maren S . The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learn Mem 2007; 14: 634–644.

Huber D, Veinante P, Stoop R . Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005; 308: 245–248.

Roberto M, Madamba SG, Moore SD, Tallent MK, Siggins GR . Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons. Proc Natl Acad Sci USA 2003; 100: 2053–2058.

Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S . Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci 2002; 22: 6810–6818.

Sullivan GM, Apergis J, Bush DE, Johnson LR, Hou M, Ledoux JE . Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulus. Neuroscience 2004; 128: 7–14.

Hitchcock JM, Davis M . Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm. Behav Neurosci 1991; 105: 826–842.

Treit D, Aujla H, Menard J . Does the bed nucleus of the stria terminalis mediate fear behaviors? Behav Neurosci 1998; 112: 379–386.

Waddell J, Morris RW, Bouton ME . Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: aversive conditioning with long-duration conditional stimuli and reinstatement of extinguished fear. Behav Neurosci 2006; 120: 324–336.

Walker DL, Miles LA, Davis M . Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33: 1291–1308.

Duvarci S, Bauer EP, Pare D . The bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear. J Neurosci 2009; 29: 10357–10361.

Resstel LB, Alves FH, Reis DG, Crestani CC, Correa FM, Guimaraes FS . Anxiolytic-like effects induced by acute reversible inactivation of the bed nucleus of stria terminalis. Neuroscience 2008; 154: 869–876.

Guo JD, Hammack SE, Hazra R, Levita L, Rainnie DG . Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes. Neuroscience 2009; 164: 1776–1793.

Bagdy G, Graf M, Anheuer ZE, Modos EA, Kantor S . Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635. Int J Neuropsychopharmacol 2001; 4: 399–408.

Singewald N, Salchner P, Sharp T . Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 2003; 53: 275–283.

Ciocchi S, Herry C, Grenier F, Wolff SB, Letzkus JJ, Vlachos I et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 2010; 468: 277–282.