A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM)

Philosophical Transactions of the Royal Society B: Biological Sciences - Tập 356 Số 1412 - Trang 1293-1322 - 2001
John C. Mazziotta1, Arthur W. Toga2, Alan C. Evans3, Peter T. Fox4, Jack L. Lancaster4, Karl Zilles5,6, Roger P. Woods1, Tomás Pauš3, Gregory V. Simpson7,8, G. Bruce Pike3, Colin J. Holmes9,8, D. Louis Collins3, Paul M. Thompson2, David MacDonald3, Marco Iacoboni1, Thorsten Schormann10,8, Katrin Amunts11,8, Nicola Palomero‐Gallagher12,8, Stefan Geyer13, Lawrence M. Parsons4, Katherine L. Narr2, Noor Jehan Kabani3, Georges Le Goualher3, Dorret I. Boomsma8,14, Tyrone D. Cannon15, Ryuta Kawashima5, Bernard Mazoyer16,8
1Ahmanson-Lovelace Brain Mapping Center, UCLA School of Medicine, 660 Charles E. Young Drive, South Los AngelesCA 90095, USA
2Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, 710 Westwood Blvd, Lost Angeles, CA 90095, USA
3McGill University/McConnell Brain Imaging Center, Montreal Neurological Institute, WB-315, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
4Research Imaging Center, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio TX 78284, USA
5Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohuku University, 4-1 Seiryomachi Aobaku, Sendai 980-9575, Japan
6University Duesseldorf, Vogt Brain Research Institute, P.O. Box 10 10 07, Duesseldorf D-40001, Germany
7Dynamic NeuroImaging Laboratory, UCSF, Department of Radiology, Box 0628, San Francisco, CA 94143, USA
8University of California at, Los Angeles
9SGI, 43L-525, 1600 Amphitheatre Pkwy, Mountain View, CA 94043-1352, USA
10Institut für Neuroanatomie und C. und O., Vogt Institut für Hirnforschung, Heinrich-Heine-Universität, Postfach 101007, D-40001, Düsseldorf, Germany
11Institut für Medizin, Forschungszentrum Jülich und Institut für Neuroanatomie, Heinrich-Heine-Universität, Postfach 101007, D-40001, Düsseldorf, Germany
12Institute of Medicine, Research Centre, Jüich, D-52425, Germany
13Institute of Neuroanatomy, Heinrich Heine University, Mooren str. 5,D-40225 Düsserldofr, Germany
14Vrije Universiteit, Department of Biological Psychology, De Bodelaan 1111, 1081 HV, Amsterdam
15UCLA Department of Psychology, Franz Hall, 405 Hilgard Avenue, Los Angeles, CA 90095-1563
16Groupe d'Imagerie Neurofonctionnelle, UMR 6095 CNRs, CES, Université de Caen, Université Paris 5, GIP Cyceron, BP5229, F-14074 Caen, France

Tóm tắt

Motivated by the vast amount of information that is rapidly accumulating about the human brain in digital form, we embarked upon a program in 1992 to develop a four–dimensional probabilistic atlas and reference system for the human brain. Through an International Consortium for Brain Mapping (ICBM) a dataset is being collected that includes 7000 subjects between the ages of eighteen and ninety years and including 342 mono– and dizygotic twins. Data on each subject includes detailed demographic, clinical, behavioural and imaging information. DNA has been collected for genotyping from 5800 subjects. A component of the programme uses post–mortem tissue to determine the probabilistic distribution of microscopic cyto– and chemoarchitectural regions in the human brain. This, combined with macroscopic information about structure and function derived from subjectsin vivo, provides the first large scale opportunity to gain meaningful insights into the concordance or discordance in micro– and macroscopic structure and function. The philosophy, strategy, algorithm development, data acquisition techniques and validation methods are described in this report along with database structures. Examples of results are described for the normal adult human brain as well as examples in patients with Alzheimer's disease and multiple sclerosis. The ability to quantify the variance of the human brain as a function of age in a large population of subjects for whom data is also available about their genetic composition and behaviour will allow for the first assessment of cerebral genotype–phenotype–behavioural correlations in humans to take place in a population this large. This approach and its application should provide new insights and opportunities for investigators interested in basic neuroscience, clinical diagnostics and the evaluation of neuropsychiatric disorders in patients.

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Philosophical Transactions of the Royal Society B: Biological Sciences

Tập 356 Số 1412

1293-1322

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