A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care

Applied Physiology, Nutrition and Metabolism - Tập 33 Số 5 - Trang 997-1006 - 2008
Marina Mourtzakis1,2, Carla M. Prado1,2, Jessica Lieffers1,2, Tony Reiman1,2, Linda J. McCargar1,2, Vickie E. Baracos1,2
1Department of Agricultural, Food and Nutritional Science, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.
2Department of Oncology, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.

Tóm tắt

Human body composition is important in numerous cancer research domains. Our objective was to evaluate clinically accessible methods to achieve practical and precise measures of body composition in cancer patients. Dual-energy X-ray absorptiometry (DXA)-based analysis of fat and fat-free mass was performed in 50 cancer patients and compared with bioelectrical impedance analysis (BIA) and with regional computed tomography (CT) images available in the patients’ medical records. BIA overestimated or underestimated fat-free mass substantially compared with DXA as the method of reference (up to 9.3 kg difference). Significant changes in fat-free mass over time detected with DXA in a subset of 21 patients (+2.2 ± 3.2%/100 days, p = 0.003), was beyond the limits of detection of BIA. Regional analysis of fat and fat-free tissue at the 3rd lumbar vertebra with either DXA or CT strongly predicted whole-body fat and fat-free mass (r = 0.86–0.94; p < 0.001). CT images provided detail on specific muscles, adipose tissues and organs, not provided by DXA or BIA. CT presents great practical significance due to the prevalence of these images in patient diagnosis and follow-up, thus marrying clinical accessibility with high precision to quantify specific tissues and to predict whole-body composition.

Từ khóa


Tài liệu tham khảo

10.1002/(SICI)1097-0142(20000215)88:4<796::AID-CNCR10>3.0.CO;2-P

Baumgartner R.N., 2000, Ann. N. Y. Acad. Sci., 904, 437, 10.1111/j.1749-6632.2000.tb06498.x

Baumgartner R.N., 1998, Am. J. Epidemiol., 147, 755, 10.1093/oxfordjournals.aje.a009520

Bland J.M., 1986, Lancet, 1, 307, 10.1016/S0140-6736(86)90837-8

10.1016/j.jamcollsurg.2006.07.001

10.1017/BJN20061943

10.1054/clnu.2001.0521

Demark-Wahnefried W., 2002, Clin. Exerc. Physiol., 4, 44

Deurenberg P., 1990, Am. J. Clin. Nutr., 51, 3, 10.1093/ajcn/51.1.3

10.1016/S0149-2918(05)80001-3

10.1002/cncr.21013

10.1016/j.clnu.2005.11.002

Gray D.S., 1989, Am. J. Clin. Nutr., 50, 255, 10.1093/ajcn/50.2.255

10.1002/1097-0142(19850101)55:1+<238::AID-CNCR2820551306>3.0.CO;2-S

Heymsfield S.B., 1990, Am. J. Clin. Nutr., 52, 214, 10.1093/ajcn/52.2.214

10.1146/annurev.nutr.17.1.527

10.1038/sj.ejcn.1601744

10.1158/1055-9965.EPI-05-0860

10.1183/09031936.98.12040960

10.1016/j.clnu.2004.06.004

10.1016/j.clnu.2004.09.012

10.1016/S0140-6736(97)11518-5

10.1158/1078-0432.CCR-04-1868

10.1158/1078-0432.CCR-06-3067

Prado C.M.M., 2008, Lancet Oncol.

10.1016/j.jada.2005.07.011

Ross R., 2000, Ann. Intern. Med., 133, 92, 10.7326/0003-4819-133-2-200007180-00008

10.1007/s005209900104

Segal K.R., 1988, Am. J. Clin. Nutr., 47, 7, 10.1093/ajcn/47.1.7

10.1177/0148607106030003222

10.1152/japplphysiol.00744.2004

Shen W., 2004, Am. J. Clin. Nutr., 80, 271, 10.1093/ajcn/80.2.271

Simons J.P.F.H.A., 1995, Am. J. Clin. Nutr., 61, 741, 10.1093/ajcn/61.4.741

10.1183/09031936.02.00279602

10.1001/archinte.160.6.861

10.1038/oby.2004.242

Thông tin
Thông tin xuất bản

Applied Physiology, Nutrition and Metabolism

Tập 33 Số 5

997-1006

Thông tin tác giả