A novel Leishmania infantum nuclear phosphoprotein Lepp12 which stimulates IL1-beta synthesis in THP-1 transfectants

BMC Microbiology - Tập 3 Số 1
Konstantina Fragaki1, B Ferrua1, Baharia Mograbi2, Julie Waldispühl1, J Kubar1
1Groupe de Recherche en Immunopathologie de la Leishmaniose (EA 2675), Faculté de Médecine, Nice, France
2Faculté de Médecine, Inserm EMI 00-092, Nice, France

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Desjeux P: UNAIDS: Leishmania and HIV in gridlock. Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland. 1998

Pearson RD, Sousa QA: Clinical spectrum of leishmaniasis. Clin Infect Dis. 1996, 22: 1-13.

Alvar J, Canavate C, Gutierrez-Solar B, Jimenez M, Laguna F, Lopez-Velez R, Molina R, Moreno J: Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev. 1997, 10: 298-319.

Kubar J, Marty P, Lelièvre A, Quaranta JF, Staccini P, Caroli-Bosc C, Le Fichoux Y: Visceral leishmaniosis in HIV-positive patients: primary infection, reactivation and latent infection. Impact of the CD4+ T-lymphocyte counts. AIDS. 1998, 12: 2147-2153. 10.1097/00002030-199816000-00009.

Dedet JP, Pratlong F: Leishmania, Trypanosoma and monoxenous trypanosomatids as emerging opportunistic agents. J Eukaryot Microbiol. 2000, 47: 37-39.

Kubar J, Quaranta JF, Marty P, Lelievre A, Le Fichoux Y, Aufeuvre JP: Transmission of L. infantum by blood donors. Nat Med. 1997, 3: 368-

Le Fichoux Y, Quaranta JF, Aufeuvre JP, Lelièvre A, Marty P, Suffia I, Rousseau D, Kubar J: Occurrence of Leishmania infantum parasitemia in asymptomatic blood donors living in an area of endemicity in southern France. J Clin Microbiol. 1999, 37: 1953-1957.

Bogdan C, Gessner A, Solbach W, Rollinghoff M: Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol. 1996, 8: 517-525. 10.1016/S0952-7915(96)80040-9.

Mauel J: Intracellular survival of protozoan parasites with special reference to Leishmania spp., Toxoplasma gondii and Trypanosoma cruzi. Adv Parasitol. 1996, 38: 1-51.

Hermoso T, Fishelson Z, Becker SI, Hirschberg K, Jaffe CL: Leishmanial protein kinases phosphorylate components of the complement system. EMBO J. 1991, 10: 4061-4067.

Bates PA: Axenic culture of Leishmania amastigotes. Parasitol Today. 1993, 9: 143-146. 10.1016/0169-4758(93)90181-E.

Zilberstein D, Shapira M: The role of pH and temperature in the developement of Leishmania parasites. Annu Rev Microbiol. 1994, 48: 449-470. 10.1146/annurev.mi.48.100194.002313.

Reiner NE: Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection. Immunol Today. 1994, 15: 374-381. 10.1016/0167-5699(94)90176-7.

Bhattacharyya S, Ghosh S, Jhonson PL, Bhattacharya SK, Majumdar S: Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infect Immun. 2001, 69: 1499-1507. 10.1128/IAI.69.3.1499-1507.2001.

Brandonisio O, Panaro MA, Sisto M, Acquafredda A, Fumarola L, Leogrande D: Interactions between Leishmania parasites and host cells. Parassitologia. 2000, 42: 183-190.

Ghosh S, Bhattacharyya S, Das S, Raha S, Maulik N, Das DK, Roy S, Majumdar S: Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival. Mol Cell Biochem. 2001, 223: 47-60. 10.1023/A:1017996609928.

Nandan D, Reiner NE: Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infect Immun. 1995, 63: 4495-4500.

Prive C, Descoteaux A: Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages. Eur J Immunol. 2000, 30: 2235-2244. 10.1002/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9.

Olivier M, Brownsey RW, Reiner NE: Defective stimulus-response coupling in human monocytes infected with Leishmania donovani is associated with altered activation and translocation of protein kinase C. Proc Natl Acad Sci. 1992, 89: 7481-7485.

Olivier M, Baimbridge KG, Reiner NE: Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates. J Immunol. 1992, 148: 1188-1196.

Corradin S, Mauel J, Ransijn A, Sturzinger C, Vergeres G: Down-regulation of MARCKS-related protein (MRP) in macrophages infected with Leishmania. J Biol Chem. 1999, 274: 16782-16787. 10.1074/jbc.274.24.16782.

Descoteaux A, Matlashewski G, Turco SJ: Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania lipophosphoglycan. J Immunol. 1992, 149: 3008-3015.

Giorgione JR, Turco SJ, Epand RM: Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani. Proc Natl Acad Sci USA. 1996, 93: 11634-11639. 10.1073/pnas.93.21.11634.

Giorgione JR, Kraayenhof R, Epand RM: Interfacial membrane properties modulate protein kinase C activation: role of the position of acyl chain unsaturation. Biochemistry. 1998, 37: 10956-10960. 10.1021/bi980185a.

McNeely TB, Rosen G, Londner MV, Turco SJ: Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania. Biochem J. 1989, 259: 601-604.

Turco SJ, Descoteaux A: The lipophosphoglycan of Leishmania parasites. Annu Rev Microbiol. 1992, 46: 65-94. 10.1146/annurev.mi.46.100192.000433.

Turco SJ: Adversarial relationship between the Leishmania lipophosphoglycan and protein kinase C of host macrophages. Parasite Immunol. 1999, 21: 597-600. 10.1046/j.1365-3024.1999.00266.x.

Turco SJ, Spath GF, Beverley SM: Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol. 2001, 17: 223-226. 10.1016/S1471-4922(01)01895-5.

Suffia I, Ferrua B, Stien X, Mograbi B, Marty P, Rousseau D, Fragaki K, Kubar J: A novel Leishmania infantum recombinant antigen which elicits Interleukin 10 production by patient PBMC. Infect Immun. 2000, 68: 630-636. 10.1128/IAI.68.2.630-636.2000.

Rafati S, Salmanian AH, Hashemi K, Schaff C, Belli S, Fasel N: Identification of Leishmania major cysteine proteinases as targets of the immune response in humans. Mol Biochem Parasitol. 2001, 113: 35-43. 10.1016/S0166-6851(00)00377-7.

Ferrua B., Le Fichoux Y, Suffia I, Rousseau D, Kubar J: Quantitation of Leishmania infantum in tissues of infected BALB/c mouse by sandwich ELISA. J Immunoassay Immunochem. 2001, 22: 165-181. 10.1081/IAS-100103227.

Chauchereau A, Loosfelt H, Milgrom E: Phosphorylation of transfected wild type and mutated progesterone receptors. J Biol Chem. 1991, 266: 18280-6.

Suffia I, Quaranta JF, Eulalio MC, Ferrua B, Marty P, Le Fichoux Y, Kubar J: Human T-cell activation by 14- and 18-kilodalton nuclear proteins of Leishmania infantum. Infect Immun. 1995, 63: 3765-3771.

Watson K, Edwards RJ: HIV-1-trans-activating (Tat) protein: both a target and a tool in therapeutic approaches. Biochem Pharmacol. 1999, 58: 1521-8. 10.1016/S0006-2952(99)00209-9.

Requena JM, Alonso C, Soto M: Evolutionarily conserved proteins as prominent immunogens during Leishmania infections. Parasitol Today. 2000, 16: 246-250. 10.1016/S0169-4758(00)01651-3.

Roux-Lombard P: The interleukin-1 family. Eur Cytokine Netw. 1998, 9: 565-76.

Hawn T, Ozinsky A, Underhill D, Buckner F, Akira S, Aderem A: Leishmania major activates IL-1alpha expression in macrophages through aMyD88-dependent pathway. Microbes Infect. 2002, 4: 763-771. 10.1016/S1286-4579(02)01596-4.

Olivier M, Tanner CE: Susceptibilities of macrophage populations to infection in vitro by Leishmania donovani. Infect Immun. 1987, 55: 467-471.

Proudfoot L, Nikolaev AV, Feng GJ, Wei WQ, Ferguson MA, Brimacombe JS, Liew FY: Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc Natl Acad Sci. 1996, 93: 10984-10989. 10.1073/pnas.93.20.10984.

Carrera L, Gazzinelli RT, Badolato R, Hieny S, Muller W, Kuhn R, Sacks DL: Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J Exp Med. 1996, 183: 515-526.

Nandan D, Lo R, Reiner NE: Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani. Infect Immun. 1999, 67: 4055-63.

Forget G, Siminovitch KA, Brochu S, Rivest S, Radzioch D, Olivier M: Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis. Eur J Immunol. 2001, 31: 3185-3196. 10.1002/1521-4141(200111)31:11<3185::AID-IMMU3185>3.0.CO;2-J.

Bhunia AK, Sarkar D, Das PK: Leishmania donovani attachment stimulates PKC-mediated oxidative events in bone marrow-derived macrophages. J Eukaryot Microbiol. 1996, 43: 373-379.

Tachado SD, Gerold P, Schwarz R, Novakovic S, McConville M, Schofield L: Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. Proc Natl Acad Sci USA. 1997, 94: 4022-4027. 10.1073/pnas.94.8.4022.

Schnur LF, Jacobson RL: Appendix III. Parasitological techniques. In The Leishmaniasis in Biology and Medicine. Edited by: Peters W, Killick-Kendrick R. 1987, London: Academic Press Inc. Limited, 516-518.

Rousseau D, Le Fichoux Y, Stien X, Suffia I, Ferrua B, Kubar J: Progression of visceral leishmaniasis due to Leishmania infantum in BALB/c mice is markedly slowed by prior infection with Trichinella spiralis. Infect Immun. 1997, 65: 4978-4983.

Ramos A, Maslov DA, Fernandes O, Campbell DA, Simpson L: Detection and identification of human pathogenic Leishmania and Trypanosoma species by hybridization of PCR-amplified mini-exon repeats. Exp Parasitol. 1996, 82: 242-250. 10.1006/expr.1996.0031.

Rousseau D, Suffia I, Ferrua B, Philip P, Le Fichoux Y, Kubar J: Prolonged administration of dexamethasone induces limited reactivation of visceral leishmaniasis in chronically infected BALB/c mice. Eur Cyt Netw. 1998, 9: 655-661.

Ferrua B, Becker P, Schaffar L, Shaw A, Fehlmann M: Detection of human interleukins 1 alpha and beta at the subpicomolar level by colorimetric sandwich enzyme mmunoassay. J Immunol Methods. 1988, 114: 41-48. 10.1016/0022-1759(88)90151-2.