A new fractional model and optimal control of a tumor-immune surveillance with non-singular derivative operator

Chaos - Tập 29 Số 8 - 2019
Dumitru Băleanu1,2, Amin Jajarmi3, Samaneh Sadat Sajjadi4, Dorota Mozyrska5
1Department of Mathematics, Faculty of Arts and Sciences, Cankaya University 1 , 06530 Ankara, Turkey
2Institute of Space Sciences 2 , P.O. Box MG-23, R 76900 Magurele-Bucharest, Romania
3Department of Electrical Engineering, University of Bojnord 3 , P.O. Box 94531-1339, Bojnord, Iran
4Department of Electrical and Computer Engineering, Hakim Sabzevari University 4 , Sabzevar, Iran
5Faculty of Computer Science, Białystok University of Technology 5 , Wiejska 45A, Białystok, Poland

Tóm tắt

In this paper, we present a new fractional-order mathematical model for a tumor-immune surveillance mechanism. We analyze the interactions between various tumor cell populations and immune system via a system of fractional differential equations (FDEs). An efficient numerical procedure is suggested to solve these FDEs by considering singular and nonsingular derivative operators. An optimal control strategy for investigating the effect of chemotherapy treatment on the proposed fractional model is also provided. Simulation results show that the new presented model based on the fractional operator with Mittag–Leffler kernel represents various asymptomatic behaviors that tracks the real data more accurately than the other fractional- and integer-order models. Numerical simulations also verify the efficiency of the proposed optimal control strategy and show that the growth of the naive tumor cell population is successfully declined.

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