A neurophysiological deficit in early visual processing in schizophrenia patients with auditory hallucinations

Psychophysiology - Tập 49 Số 9 - Trang 1168-1178 - 2012
Jürgen Kayser1,2, Craig E. Tenke1,2, Christopher J. Kroppmann2, Daniel M. Alschuler2, Shiva Fekri2, Roberto Gil3,1, L. Fredrik Jarskog1,4, Jill Harkavy‐Friedman1, Gerard E. Bruder1,2
1Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
2Division of Cognitive Neuroscience New York State Psychiatric Institute New York New York USA
3Clinical Psychobiology New York State Psychiatric Institute New York New York USA
4Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina USA

Tóm tắt

AbstractExisting 67‐channel event‐related potentials, obtained during recognition and working memory paradigms with words or faces, were used to examine early visual processing in schizophrenia patients prone to auditory hallucinations (AH, n = 26) or not (NH, n = 49) and healthy controls (HC, n = 46). Current source density (CSD) transforms revealed distinct, strongly left‐ (words) or right‐lateralized (faces; N170) inferior‐temporal N1 sinks (150 ms) in each group. N1 was quantified by temporal PCA of peak‐adjusted CSDs. For words and faces in both paradigms, N1 was substantially reduced in AH compared with NH and HC, who did not differ from each other. The difference in N1 between AH and NH was not due to overall symptom severity or performance accuracy, with both groups showing comparable memory deficits. Our findings extend prior reports of reduced auditory N1 in AH, suggesting a broader early perceptual integration deficit that is not limited to the auditory modality.

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Tài liệu tham khảo

10.1016/j.neubiorev.2007.07.012

American Psychiatric Association, 1994, Diagnostic and statistical manual of mental disorders

Andreasen N. C., 1983, The Scale for the Assessment of Negative Symptoms (SANS)

Andreasen N. C., 1984, The Scale for the Assessment of Positive Symptoms (SAPS)

10.1016/j.neubiorev.2011.07.010

10.1146/annurev.clinpsy.1.102803.143959

10.1037/a0021661

10.1037/0021‐843X.107.3.399

10.1176/ajp.152.6.932

10.1093/brain/awl233

10.1093/brain/123.2.291

Dixon W. J., 1992, BMDP statistical software manual: To accompany the 7.0 software release

10.1001/archpsyc.59.11.1011

10.1016/0920‐9964(94)90020‐5

First M. B., 1996, Structured Clinical Interview for DSM‐IV Axis‐I Disorders—Non‐patient Edition (SCID‐NP)

10.1111/1469‐8986.3660667

10.1176/appi.ajp.158.11.1914

10.1093/schbul/sbn140

10.1016/0006‐3223(94)91221‐1

10.1097/00001756‐200112040‐00043

10.1007/s00406‐010‐0176‐0

10.1176/ajp.151.3.357

10.1001/archpsyc.64.11.1229

10.1093/cercor/10.1.69

10.1192/bjp.bp.106.022954

10.1080/13546800801906808

10.3389/neuro.09.006.2007

10.1146/annurev.clinpsy.032408.153502

10.1001/archpsyc.57.12.1131

10.1016/j.neuroimage.2006.09.024

Kay S. R., 1992, Positive and Negative Syndrome Scale (PANSS) rating manual

Kayser J.(2009).Current source density (CSD) interpolation using spherical splines: CSD toolbox (Version 1.1). Retrieved fromhttp://psychophysiology.cpmc.columbia.edu/Software/CSDtoolbox

10.1016/S0167‐8760(99)00082‐3

10.1016/S0006‐3223(00)01090‐8

10.1016/S0926‐6410(02)00205‐7

10.1016/S1388‐2457(03)00241‐4

10.1016/j.clinph.2005.08.034

Kayser J., 2006, Electrical distance as a reference‐free measure for identifying artifacts in multichannel electroencephalogram (EEG) recordings, Psychophysiology, 43, S51

10.1016/j.clinph.2010.04.030

10.1111/j.1469‐8986.2007.00562.x

10.1111/j.1469‐8986.2006.00398.x

10.1016/j.ijpsycho.2009.02.003

10.1016/j.ijpsycho.2009.12.001

10.1097/00041327‐200406000‐00003

10.1152/physrev.1985.65.1.37

10.1111/j.1469‐8986.1986.tb00659.x

10.1016/j.clinph.2010.06.011

NeuroScan, Inc., 2003, SCAN 4.3. Vol. II. EDIT 4.3—Offline analysis of acquired data

10.1109/TBME.1973.324192

10.1093/acprof:oso/9780195050387.001.0001

10.1001/archpsyc.1994.03950110009002

10.1046/j.1469‐7580.2000.19730335.x

10.1016/0167‐8760(84)90014‐X

10.1016/j.schres.2004.08.017

10.1016/0013‐4694(89)90180‐6

10.1001/archpsyc.1989.01810110077011

10.1111/j.1469‐8986.1993.tb02081.x

10.1046/j.1469‐7580.2000.19730335.x

10.1111/j.1749‐6632.2010.05444.x

10.1016/j.psychres.2008.03.017

10.1016/j.neuroimage.2007.10.011

10.1093/schbul/sbp003

10.1037/0096‐3445.117.1.34

Spitzer R. L., 1990, Structured Clinical Interview for DSM‐III‐R: Patient edition

10.1016/S1388-2457(00)00553-8

Tenke C. E. &Kayser J.(2012).Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions. Clinical Neurophysiology in press. doi: 10.1016/j.clinph.2012.06.005

10.1016/j.neuroimage.2011.01.001

10.1016/0959‐4388(94)90066‐3

10.3389/fpsyt.2011.00028

10.1093/schbul/sbn142

10.4088/JCP.v64n0607

10.1001/archpsyc.63.11.1180

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Psychophysiology

Tập 49 Số 9

1168-1178

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