A model of lipid dysregulation and altered nutrient status in Alzheimer's disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 5 - Trang 139-145 - 2019
Keith Fluegge1
1Institute of Health and Environmental Research, Columbus OH 43220

Tóm tắt

AbstractIntroductionDysregulated lipid metabolism and nutrient status are thought to play a role in the pathophysiology of Alzheimer's disease (AD). However, the precise involvement is not well understood, and it remains unclear exactly how such dysregulated lipid metabolism and altered nutrient status, especially changes in phosphatidylcholine, B12, and folate, are connected to the hallmark pathology in AD (i.e., amyloidogenesis).MethodsWe have postulated that genetic susceptibility (i.e., APOE ε4/ε4) to environmental exposure to emissions of nitrous oxide (N2O) could underlie the onset of AD and its early neuropsychiatric correlatesResults and DiscussionThe current theoretical editorial describes, using clinical, preclinical, and in vitro evidences, how this model contributes not only to amyloidogenesis but also other nonopioid effects, specifically altered lipid metabolism, depletion of vitamin B12, and disruption of the folate‐mediated one carbon metabolic pathway.

Tài liệu tham khảo

10.1016/S0140-6736(15)01124-1 10.2174/1567205012666150204121719 10.1101/cshperspect.a006189 De Wilde M.C., 2017, Lower brain and blood nutrient status in Alzheimer's disease: results from meta‐analyses, Alzheimers Dement, 3, 416, 10.1016/j.trci.2017.06.002 10.1016/j.neuint.2017.08.005 K.Fluegge.Environmental factors influencing the link between APOE ε4 and Alzheimer's disease (AD) risk.Int Psychoger 2018;1–2 K.Fluegge.Tau Protein Levels in ADHD.Ind J Clin Biochem 2018 https://doi.org/10.1007/s12291‐018‐0747‐9 Eftimova B., 2017, Health effects associated with exposure to anesthetic gas nitrous oxide‐N2O in clinical hospital ‐ shtip personel, Open Access Maced J Med Sci, 5, 800, 10.3889/oamjms.2017.185 10.1016/j.mrfmmm.2011.10.010 10.1093/bja/aem280 10.1213/ANE.0b013e3181f7e2c4 10.1016/j.braindev.2018.12.003 Kang S.W., 2018, Neurological manifestations of myeloneuropathy in patients with nitrous oxide intoxication, J Clin Neurol, 15, 116, 10.3988/jcn.2019.15.1.116 Vozy A., 2016, Medullar toxicity after prolonged nitrous oxide exposure: an unexpected cause of bone marrow failure post allogeneic transplant, Bone Marrow Transpl, 51, 876, 10.1038/bmt.2015.314 10.3390/toxics6040070 Uil S.H., 2018, Aortic arch thrombus caused by nitrous oxide abuse, J Vasc Surg Cases Innov Tech, 4, 80, 10.1016/j.jvscit.2018.01.001 Indraratna P., 2017, Acute ST‐Elevation myocardial infarction, a unique complication of recreational nitrous oxide use, Heart Lung Circ, 26, e41, 10.1016/j.hlc.2017.01.019 Tavare A.N., 2018, Pneumomediastinum and pneumorrhachis from recreational nitrous oxide inhalation: no laughing matter, Thorax, 73, 195, 10.1136/thoraxjnl-2017-210291 10.1093/omcr/omw012 10.1111/ajad.12372 Bajaj D., 2018, Recreational nitrous oxide abuse causing ischemic stroke in a young patient: a rare case report, Cureus, 10, e3761 10.1371/journal.pone.0156097 10.1186/s13195-017-0322-2 10.1016/j.jamda.2015.12.092 10.1016/j.neuron.2010.05.014 10.3233/JAD-140666 10.1371/journal.pone.0184244 10.1097/00000542-197405000-00010 Lortie J.J., 2012, Lack of correlation of WAIS Digit Span with clox 1 and the dementia rating scale in MCI, Int J Alzheimers Dis, 2012, 829743 10.1016/S0091-3057(99)00202-6 10.1213/01.ane.0000247792.03959.f1 10.1111/jnc.13279 10.1523/JNEUROSCI.18-23-09716.1998 10.1016/j.neurobiolaging.2006.07.002 10.1016/j.neuroscience.2003.08.033 10.1016/0006-8993(94)01333-D 10.1097/ALN.0b013e3181b27fd4 10.1097/00000539-200302000-00028 10.1016/j.neurobiolaging.2017.03.016 10.1523/JNEUROSCI.0354-12.2012 10.1093/oxfordjournals.jbchem.a003016 10.1210/en.2014-1063 10.1016/S0006-8993(01)02018-2 10.1016/0024-3205(95)00220-Z 10.1016/j.bbamem.2013.10.018 10.1046/j.1471-4159.2001.00471.x Hazzard J.H., 1985, Determination of anesthetic molecule environments by infrared spectroscopy. II. Multiple sites for nitrous oxide in proteins, lipids, and brain tissue, Arch Biochem Biophys, 240, 747, 10.1016/0003-9861(85)90083-9 10.1016/0005-2736(80)90098-X 10.1097/00000542-198604000-00013 10.1079/BJN19780155 Abdul‐Kareem H.S., 1991, Effects of repeated intermittent exposures to nitrous oxide on central neurotransmitters and hepatic methionine synthetase activity in CD‐1 mice, Toxicol Ind Health, 7, 97 10.1111/j.1399-3011.1996.tb00813.x 10.1016/j.bbalip.2012.09.009 10.1111/j.1471-4159.1981.tb02373.x 10.1016/j.neurobiolaging.2006.06.018 10.1016/S0006-2952(99)00033-7 10.1097/ALN.0b013e318178820b 10.1159/000457020 10.1093/ajcn/34.11.2418 10.1212/WNL.56.9.1188 The Global Alzheimer's Association Interactive Network (GAAIN).The Interrogator: Explore Big Data.https://www.gaaindata.org/data3/explore/login.jsp;jsessionid=0502F1E2C341E9E13F97487AF68AC3CFAccessed February 2018. 10.1097/WAD.0b013e318142774e Health Quality Ontario, 2013, Vitamin B12 and Cognitive Function: An Evidence‐Based Analysis, Ontario Health Technology Assess Ser, 13, 1 10.1016/j.bj.2018.06.001 10.1016/j.envpol.2018.01.076 10.1088/1748-9326/8/2/025022 10.12659/MSM.899976 10.1007/s12402-012-0084-4 10.1007/s12291-016-0602-9 10.1016/j.envres.2018.05.009 10.3389/fnagi.2017.00260
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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 5

139-145

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