A lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis?

Journal of Feline Medicine and Surgery - Tập 11 - Trang 91-95 - 2009
Francesca Mancianti1, Sara Dabizzi2, Simona Nardoni1
1Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, University of Pisa, Viale delle Piagge 2, I 56124 Pisa, Italy
2Dipartimento di Patologia Animale, Università di Pisa, Italy.

Tóm tắt

The effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50 mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100 mg/kg by-weekly for 8 weeks) was tested on 25 (11+14) Microsporum canis infected cats. Control animals were treated with lufenuron, griseofulvin and enilconazole alone. At day 150 pre-treated animals were culturally negative and clinically cured. While lufenuron alone was found to be ineffective against M canis infection, an immunomodulatory effect of the drug can be suggested, as reported in literature. Its use could be reserved to long-lasting infections, unsuccessfully treated with conventional drugs. Further studies are required to clearly establish the possible adjuvant effect of this molecule when used prior to enilconazole or griseofulvin.

Tài liệu tham khảo

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Thông tin xuất bản

Journal of Feline Medicine and Surgery

Tập 11

91-95

Thông tin tác giả