A dopamine receptor genetic variant enhances perceptual speed in cognitive healthy subjects

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 3 - Trang 254-261 - 2017
Sandra Barral1, Christian G. Habeck2, Elaine Gazes2, Philip L. De Jager3, David A. Bennett4,5, Yaakov Stern1,2
1Department of Neurology, G.H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
2Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
3Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
4Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA
5Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

Tóm tắt

AbstractIntroductionCognition is under strong genetic control, yet the specific genes are unknown.MethodsOne hundred and fifty‐three cognitive healthy European subjects from the Reference Abilities Study (RANN) were genotyped for 1,160 variants within 446 neuropsychiatric genes. Adjusted linear regression models evaluated the association between the genetic variants and four reference abilities (Vocabulary, Episodic Memory, Perceptual Speed, and Reasoning).ResultsOne hundred and fifty‐nine variants nominally were found significant in the RANN cohort and re‐evaluated in an independent cohort of 868 cognitive healthy subjects from the Religious Orders Study and Rush Memory Aging Project. Meta‐analysis yielded a Bonferroni adjusted statistically significant association between perceptual speed and a variant located in the promoter of the dopamine receptor D4 gene, rs3756450 (β = 0.23, standard error = 0.05, Pmeta = 2.3 × 10−5).DiscussionOur data suggest that genetic variation in a dopamine pathway gene influences perceptual speed performance in cognitively healthy individuals.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 3

254-261

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