A comprehensive survey on computational methods of non-coding RNA and disease association prediction

Briefings in Bioinformatics - Tập 22 Số 4 - 2021
Xiujuan Lei1, Thosini Bamunu Mudiyanselage2, Yuchen Zhang1, Chen Bian1, Wei Lan3, Ning Yu4, Yi Pan5
1School of Computer Science, Shaanxi Normal University, Xi’an, China
2Department of Computer Science, Georgia State University, Atlanta, GA 30302, USA
3School of Computer, Electronics and Information at Guangxi University, Nanning, China
4Department of Computing Sciences at the College at Brockport, State University of New York, Rochester, NY, USA
5Computer Science Department at Georgia State University, Atlanta, GA, USA

Tóm tắt

AbstractThe studies on relationships between non-coding RNAs and diseases are widely carried out in recent years. A large number of experimental methods and technologies of producing biological data have also been developed. However, due to their high labor cost and production time, nowadays, calculation-based methods, especially machine learning and deep learning methods, have received a lot of attention and been used commonly to solve these problems. From a computational point of view, this survey mainly introduces three common non-coding RNAs, i.e. miRNAs, lncRNAs and circRNAs, and the related computational methods for predicting their association with diseases. First, the mainstream databases of above three non-coding RNAs are introduced in detail. Then, we present several methods for RNA similarity and disease similarity calculations. Later, we investigate ncRNA-disease prediction methods in details and classify these methods into five types: network propagating, recommend system, matrix completion, machine learning and deep learning. Furthermore, we provide a summary of the applications of these five types of computational methods in predicting the associations between diseases and miRNAs, lncRNAs and circRNAs, respectively. Finally, the advantages and limitations of various methods are identified, and future researches and challenges are also discussed.

Từ khóa


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