A case of common variable immunodeficiency associated with cyclic thrombocytopenia

Pediatrics International - Tập 36 Số 6 - Trang 690-692 - 1994
Masaru Kubota1, Keizō Sugimachi, Koichi Watanabe, Hajime Kimata, Harukí Mikawa
1Department of Pediatrics, Kyoto University, Japan

Tóm tắt

AbstractA 12 year old boy was found to be deficient in immunoglobulins (Ig) A, G2 and G4, and common variable immunodeficiency was diagnosed. He also had cyclic thrombocytopenia at intervals of approximately 28–30 days. His bone marrow revealed normocellular with slightly decreased megakaryocytes. In vitro colony assays showed markedly imparied megakaryocytopoiesis, erythropoiesis and granulopoiesis. Platelet‐associated IgG was elevated at his thrombocytopenic phase. Direct Coombs' test was repeatedly positive. Although not defined at present, we suggest the autoimmune nature of the disease.

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Tài liệu tham khảo

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Pediatrics International

Tập 36 Số 6

690-692

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