A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

American Association for the Advancement of Science (AAAS) - Tập 348 Số 6239 - Trang 1160-1163 - 2015
Weiqi Zhang1, Jingyi Li2, Keiichiro Suzuki3, Jing Qu4, Ping Wang1, Junzhi Zhou1, Xiaomeng Liu2, Ruotong Ren1, Xiuling Xu1, Alejandro Ocampo3, Tingting Yuan1, Jiping Yang1, Ying Li1, Liang Shi5, Dee Guan1, Huize Pan1, Shunlei Duan1, Zhichao Ding1, Mo Li3, Fei Yi6, Ruijun Bai4, Ya‐Yu Wang5, Chang Chen1, Fuquan Yang1, Xiaoyu Li7, Zimei Wang8, Emi Aizawa3, April Goebl3,9, Rupa Devi Soligalla3, Pradeep Reddy3, Concepción Rodrı́guez Esteban3, Fuchou Tang2,10,11,12, Guang‐Hui Liu13,10,1,8, Juan Carlos Izpisúa Belmonte3
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China
3Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
4State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
5Diagnosis and Treatment Center for Oral Disease, the 306th Hospital of the PLA, Beijing, China.
6Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
7College of Life Sciences, Peking University, Beijing 100871, China
8The Center for Anti-aging and Regenerative Medicine, Shenzhen University, Shenzhen 518060, China.
9Universidad Católica San Antonio de Murcia, Campus de los Jerónimos s/n, 30107 Guadalupe, Murcia, Spain.
10Center for Molecular and Translational Medicine (CMTM), Beijing 100101, China.
11Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China
12Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
13Beijing Institute for Brain Disorders, Beijing 100069, China

Tóm tắt

Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cell lines (see the Perspective by Brunauer and Kennedy). WS-mesenchymal stem cells displayed features characteristic of premature aging, including heterochromatin disorganization. WRN protein thus functions in the maintenance of heterochromatin, and heterochromatin alterations may represent a driving force of human aging. Science , this issue p. 1160 ; see also p. 1093

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