A Web Tool for Age–Period–Cohort Analysis of Cancer Incidence and Mortality Rates
Tóm tắt
Background: Age–period–cohort (APC) analysis can inform registry-based studies of cancer incidence and mortality, but concerns about statistical identifiability and interpretability, as well as the learning curves of statistical software packages, have limited its uptake.
Methods: We implemented a panel of easy-to-interpret estimable APC functions and corresponding Wald tests in R code that can be accessed through a user-friendly Web tool.
Results: Input data for the Web tool consist of age-specific numbers of events and person-years over time, in the form of a rate matrix of paired columns. Output functions include model-based estimators of cross-sectional and longitudinal age-specific rates, period and cohort rate ratios that incorporate the overall annual percentage change (net drift), and estimators of the age-specific annual percentage change (local drifts). The Web tool includes built-in examples for teaching and demonstration. User data can be input from a Microsoft Excel worksheet or by uploading a comma-separated–value file. Model outputs can be saved in a variety of formats, including R and Excel.
Conclusions: APC methodology can now be carried out through a freely available user-friendly Web tool. The tool can be accessed at http://analysistools.nci.nih.gov/apc/.
Impact: The Web tool can help cancer surveillance researchers make important discoveries about emerging cancer trends and patterns. Cancer Epidemiol Biomarkers Prev; 23(11); 2296–302. ©2014 AACR.
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Tài liệu tham khảo
International Agency for Research on Cancer, 2009, Cancer incidence in five continents, volume IX
Eheman, 2012, Annual Report to the Nation on the status of cancer, 1975–2008, featuring cancers associated with excess weight and lack of sufficient physical activity, Cancer, 118, 2338, 10.1002/cncr.27514
Bray, 2012, Global cancer transitions according to the Human Development Index (2008–2030): a population-based study, Lancet Oncol, 13, 790, 10.1016/S1470-2045(12)70211-5
Devesa, 1995, Graphical presentation of trends in rates, Am J Epidemiol, 141, 300, 10.1093/aje/141.4.300
Robertson, 1998, Age-period-cohort models of chronic disease rates. II: graphical approaches, Stat Med, 17, 1325, 10.1002/(SICI)1097-0258(19980630)17:12<1325::AID-SIM854>3.0.CO;2-R
Fay, 2006, Estimating average annual percent change for disease rates without assuming constant change, Biometrics, 62, 847, 10.1111/j.1541-0420.2006.00528.x
Kim, 2000, Permutation tests for joinpoint regression with applications to cancer rates, Stat Med, 19, 335, 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z
Bergstrom, 1996, Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon, J Nat Cancer Inst, 88, 727, 10.1093/jnci/88.11.727
Verhoeven, 2008, Testicular cancer: marked birth cohort effects on incidence and a decline in mortality in southern Netherlands since 1970, Int J Cancer, 122, 639, 10.1002/ijc.23061
Liu, 2000, Clues to the aetiological heterogeneity of testicular seminomas and non-seminomas: time trends and age-period-cohort effects, Int J Epidemiol, 29, 826, 10.1093/ije/29.5.826
Bray, 2006, Do testicular seminoma and nonseminoma share the same etiology? Evidence from an age-period-cohort analysis of incidence trends in eight European countries, Cancer Epidemiol Biomarkers Prev, 15, 652, 10.1158/1055-9965.EPI-05-0565
Spix, 2008, Temporal trends in the incidence rate of childhood cancer in Germany 1987–2004, Int J Cancer, 122, 1859, 10.1002/ijc.23281
McNally, 2001, Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues, Leukemia, 15, 1612, 10.1038/sj.leu.2402252
Svensson, 2005, Early life events and later risk of colorectal cancer: age-period-cohort modelling in the Nordic countries and Estonia, Cancer Causes Control, 16, 215, 10.1007/s10552-004-3073-x
Chu, 1999, Breast cancer trends of black women compared with white women, Arch Fam Med, 8, 521, 10.1001/archfami.8.6.521
Sim, 2006, Ethnic differences in the time trend of female breast cancer incidence: Singapore, 1968–2002, BMC Cancer, 6, 261, 10.1186/1471-2407-6-261
Holford, 2006, Changing patterns in breast cancer incidence trends, J Natl Cancer Inst Monogr, 19, 10.1093/jncimonographs/lgj016
McNally, 1997, Age and sex distributions of hematological malignancies in the U.K, Hematol Oncol, 15, 173, 10.1002/(SICI)1099-1069(199711)15:4<173::AID-HON610>3.0.CO;2-K
Bacher, 2005, Population-based age-specific incidences of cytogenetic subgroups of acute myeloid leukemia, Haematologica, 90, 1502
Tarone, 2002, The greater impact of menopause on ER- than ER+ breast cancer incidence: a possible explanation (United States), Cancer Causes Control, 13, 7, 10.1023/A:1013960609008
Anderson, 2004, Comparison of age-specific incidence rate patterns for different histopathologic types of breast carcinoma, Cancer Epidemiol Biomarkers Prev, 13, 1128, 10.1158/1055-9965.1128.13.7
Chu, 1994, Temporal patterns in colorectal cancer incidence, survival, and mortality from 1950 through 1990, J Natl Cancer Inst, 86, 997, 10.1093/jnci/86.13.997
Corrao, 1997, Trends of liver cirrhosis mortality in Europe, 1970–1989: age-period-cohort analysis and changing alcohol consumption, Int J Epidemiol, 26, 100, 10.1093/ije/26.1.100
Jemal, 2012, Increasing lung cancer death rates among young women in southern and midwestern states, J Clin Oncol, 30, 2739, 10.1200/JCO.2012.42.6098
de Vries, 2003, Changing epidemiology of malignant cutaneous melanoma in Europe 1953–1997: rising trends in incidence and mortality but recent stabilizations in western Europe and decreases in Scandinavia, Int J Cancer, 107, 119, 10.1002/ijc.11360
Bray, 2006, Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality, Int J Cancer, 118, 3099, 10.1002/ijc.21747
Cayuela, 2007, Age-period-cohort analysis of lung cancer mortality rates in Andalusia, 1975–2004, Lung Cancer, 57, 261, 10.1016/j.lungcan.2007.03.015
Holford, 2005, Age-period-cohort analysis. Encyclopedia of Biostatistics, 82
Clayton, 1987, Models for temporal variation in cancer rates. I: age-period and age-cohort models, Stat Med, 6, 449, 10.1002/sim.4780060405
Clayton, 1987, Models for temporal variation in cancer rates. II: Age-period-cohort models, Stat Med, 6, 469, 10.1002/sim.4780060406
Robertson, 1998, Age-period-cohort analysis of chronic disease rates. I: modelling approach, Stat Med, 17, 1305, 10.1002/(SICI)1097-0258(19980630)17:12<1305::AID-SIM853>3.0.CO;2-W
Tarone, 1996, Evaluation of birth cohort patterns in population disease rates, Am J Epidemiol, 143, 85, 10.1093/oxfordjournals.aje.a008661
Tarone, 2000, Nonparametric evaluation of birth cohort trends in disease rates, J Epidemiol Biostat, 5, 177
Rosenberg, 2011, Age-period-cohort models in cancer surveillance research: ready for prime time, Cancer Epidemiol Biomarkers Prev, 20, 1263, 10.1158/1055-9965.EPI-11-0421
Anderson, 2008, Age-related crossover in breast cancer incidence rates between black and white ethnic groups, J Natl Cancer Inst, 100, 11, 10.1093/jnci/djn411
Speaks, 2012, Significant calendar period deviations in testicular germ cell tumors indicate that postnatal exposures are etiologically relevant, Cancer Causes Control, 23, 1593, 10.1007/s10552-012-0036-5
Yang, 2013, Ovarian cancer incidence trends in relation to changing patterns of menopausal hormone therapy use in the United States, J Clin Oncol, 31, 2146, 10.1200/JCO.2012.45.5758
Ma, 2013, Pancreatic cancer death rates by race among US men and women, 1970–2009, J Natl Cancer Inst, 105, 1694, 10.1093/jnci/djt292
Rosenberg, 2012, Are incidence rates of adult leukemia in the United States significantly associated with birth cohort, Cancer Epidemiol Biomarkers Prev, 21, 2159, 10.1158/1055-9965.EPI-12-0910
Mbulaiteye, 2010, Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973–2005, Int J Cancer, 126, 1732, 10.1002/ijc.24934
Chaturvedi, 2013, Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers, J Clin Oncol, 31, 4550, 10.1200/JCO.2013.50.3870
Anderson, 2013, Divergent estrogen receptor positive and negative breast cancer trends and etiologic heterogeneity in Denmark, Int J Cancer, 133, 2201, 10.1002/ijc.28222
Holford, 1983, The estimation of age, period and cohort effects for vital rates, Biometrics, 39, 311, 10.2307/2531004
Holford, 2006, Approaches to fitting age-period-cohort models with unequal intervals, Stat Med, 25, 977, 10.1002/sim.2253
Rosenberg, 2010, Proportional hazards models and age-period-cohort analysis of cancer rates, Stat Med, 29, 1228, 10.1002/sim.3865
Parkin, 2001, Cancer burden in the year 2000. The global picture, Eur J Cancer, 37, S4, 10.1016/S0959-8049(01)00267-2
Anderson, 2009, Male breast cancer: a population-based comparison with female breast cancer, J Clin Oncol, 28, 232, 10.1200/JCO.2009.23.8162
Anderson, 2009, Divergent cancer pathways for early-onset and late-onset cutaneous malignant melanoma, Cancer, 115, 4176, 10.1002/cncr.24481
Grimley, 2009, Qualitative age interactions between low-grade and high-grade serous ovarian carcinomas, Cancer Epidemiol Biomarkers Prev, 18, 2256, 10.1158/1055-9965.EPI-09-0240
Reimers, 2009, Etiologic heterogeneity for cervical carcinoma by histopathologic type, using comparative age-period-cohort models, Cancer Epidemiol Biomarkers Prev, 18, 792, 10.1158/1055-9965.EPI-08-0965
Kilfoy, 2009, Gender is an age-specific effect modifier for papillary cancers of the thyroid gland, Cancer Epidemiol Biomarkers Prev, 18, 1092, 10.1158/1055-9965.EPI-08-0976