A Role for Nanoparticles in Treating Traumatic Brain Injury
Tóm tắt
Từ khóa
Tài liệu tham khảo
Prevention, C.F.D.C.A. (2019). Surveillance Report of Traumatic Brain Injury-related Emergency Department Visits, Hospitalizations, and Deaths—United States, 2014, Centers for Disease Control and Prevention.
Bharadwaj, 2018, Nanoparticle-Based Therapeutics for Brain Injury, Adv. Healthc. Mater., 7, 1700668, 10.1002/adhm.201700668
Feigin, 2010, Epidemiology of ischaemic stroke and traumatic brain injury, Best Pract. Res. Clin. Anaesthesiol., 24, 485, 10.1016/j.bpa.2010.10.006
Langlois, 2006, The epidemiology and impact of traumatic brain injury: A brief overview, J. Head Trauma Rehabil., 21, 375, 10.1097/00001199-200609000-00001
Hall, 2010, Antioxidant therapies for traumatic brain injury, Neurother. J. Am. Soc. Exp. Neurother., 7, 51
Slemmer, 2008, Antioxidants and Free Radical Scavengers for the Treatment of Stroke, Traumatic Brain Injury and Aging, Curr. Med. Chem., 15, 404, 10.2174/092986708783497337
Chen, 2010, Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection, Antioxid. Redox Signal., 14, 1505, 10.1089/ars.2010.3576
Readnower, 2010, Increase in blood–brain barrier permeability, oxidative stress, and activated microglia in a rat model of blast-induced traumatic brain injury, J. Neurosci. Res., 88, 3530, 10.1002/jnr.22510
Cornelius, 2013, Traumatic Brain Injury: Oxidative Stress and Neuroprotection, Antioxid. Redox Signal., 19, 836, 10.1089/ars.2012.4981
Heidenrreich, K.A. (2017). Carbonyl Scavenging as an Antioxidant Neuroprotective Strategy for Acute Traumatic Brain Injury. N. Ther. Trauma. Brain Inj. Prev. Second. Brain Damage Enhanc. Repair Regen, Elsevier.
Simon, 2017, The far-reaching scope of neuroinflammation after traumatic brain injury, Nat. Rev. Neurol., 13, 171, 10.1038/nrneurol.2017.13
Johnson, 2013, Inflammation and white matter degeneration persist for years after a single traumatic brain injury, Brain, 136, 28, 10.1093/brain/aws322
Heneka, 2015, Neuroinflammation in Alzheimer’s disease, Lancet Neurol., 14, 388, 10.1016/S1474-4422(15)70016-5
McKee, 2013, The spectrum of disease in chronic traumatic encephalopathy, Brain, 136, 43, 10.1093/brain/aws307
Gardner, 2014, Dementia risk after traumatic brain injury vs nonbrain trauma: The role of age and severity, JAMA Neurol., 71, 1490, 10.1001/jamaneurol.2014.2668
Gustafson, 2014, Traumatic brain injury and young onset dementia: A nationwide cohort study, Ann. Neurol., 75, 374, 10.1002/ana.24101
Shively, 2012, Dementia resulting from traumatic brain injury: What is the pathology?, Arch. Neurol., 69, 1245, 10.1001/archneurol.2011.3747
McConeghy, 2012, A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury, CNS Drugs, 26, 613, 10.2165/11634020-000000000-00000
Wright, 2007, ProTECT: A randomized clinical trial of progesterone for acute traumatic brain injury, Ann. Emerg. Med., 49, 391, 10.1016/j.annemergmed.2006.07.932
Roof, 1997, Progesterone protects against lipid peroxidation following traumatic brain injury in rats, Mol. Chem. Neuropathol., 31, 1, 10.1007/BF02815156
Wei, 2013, The neuroprotective effects of progesterone on traumatic brain injury: Current status and future prospects, Acta Pharmacol. Sin., 34, 1485, 10.1038/aps.2013.160
Albensi, 2000, Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity, Exp. Neurol., 162, 385, 10.1006/exnr.1999.7338
Kochanek, 2018, Operation Brain Trauma Therapy: 2016 Update, Mil. Med., 183, 303, 10.1093/milmed/usx184
Kim, 2010, Tuning payload delivery in tumour cylindroids using gold nanoparticles, Nat. Nanotechnol., 5, 465, 10.1038/nnano.2010.58
Mok, 2008, Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal, Bioconjugate Chem., 19, 797, 10.1021/bc700464m
Xu, 2007, Targeted charge-reversal nanoparticles for nuclear drug delivery, Angew. Chem. Int. Ed., 46, 4999, 10.1002/anie.200605254
Zhou, 2009, Charge-Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery, Adv. Funct. Mater., 19, 3580, 10.1002/adfm.200900825
Kievit, 2010, Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma, ACS Nano, 4, 4587, 10.1021/nn1008512
Choi, 2010, Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles, Proc. Natl. Acad. Sci. USA, 107, 1235, 10.1073/pnas.0914140107
Kirpotin, 2006, Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models, Cancer Res., 66, 6732, 10.1158/0008-5472.CAN-05-4199
Kievit, 2012, Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs, ACS Nano, 6, 2591, 10.1021/nn205070h
Kwon, 2016, Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries, ACS Nano, 10, 7926, 10.1021/acsnano.6b03858
Baldwin, 1996, Blood-brain barrier breach following cortical contusion in the rat, J. Neurosurg., 85, 476, 10.3171/jns.1996.85.3.0476
Komarova, 2017, Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability, Circ. Res., 120, 179, 10.1161/CIRCRESAHA.116.306534
Lecuyer, 2017, Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis, Proc. Natl. Acad. Sci. USA, 114, E524, 10.1073/pnas.1614336114
Guerra, 2017, Blood-brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow, Fluids Barriers CNS, 14, 19, 10.1186/s12987-017-0067-0
Kim, 2017, Neurometabolic indicators of mitochondrial dysfunction in repetitive mild traumatic brain injury, Concussion, 2, CNC45, 10.2217/cnc-2017-0013
Main, 2018, Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury, Mol. Neurodegener., 13, 17, 10.1186/s13024-018-0249-5
Neuwelt, 2008, Strategies to advance translational research into brain barriers, Lancet Neurol., 7, 84, 10.1016/S1474-4422(07)70326-5
Khalin, 2016, Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury, Drug Deliv., 23, 3520, 10.1080/10717544.2016.1199609
Ruozi, 2015, PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury, Mol. Neurobiol., 52, 899, 10.1007/s12035-015-9235-x
Gaudin, 2014, Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury, Nat. Nanotechnol., 9, 1054, 10.1038/nnano.2014.274
Kawaguchi, 2009, Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats, Artif. Organs, 33, 153, 10.1111/j.1525-1594.2008.00700.x
Kizelsztein, 2009, Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis, J. Neuroimmunol., 213, 20, 10.1016/j.jneuroim.2009.05.019
Heckman, 2013, Custom cerium oxide nanoparticles protect against a free radical mediated autoimmune degenerative disease in the brain, ACS Nano, 7, 10582, 10.1021/nn403743b
Kim, 2012, Ceria Nanoparticles that can Protect against Ischemic Stroke, Angew. Chem. Int. Ed., 51, 11039, 10.1002/anie.201203780
Saraiva, 2016, Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases, J. Control. Release, 235, 34, 10.1016/j.jconrel.2016.05.044
Bhaskar, 2010, Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: Perspectives on tracking and neuroimaging, Part. Fibre Toxicol., 7, 3, 10.1186/1743-8977-7-3
Mikitsh, 2014, Pathways for small molecule delivery to the central nervous system across the blood-brain barrier, Perspect. Med. Chem., 6, 11
Maeda, 2000, Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review, J. Control. Release, 65, 271, 10.1016/S0168-3659(99)00248-5
Shlosberg, 2010, Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury, Nat. Rev. Neurol., 6, 393, 10.1038/nrneurol.2010.74
Masserini, 2013, Nanoparticles for Brain Drug Delivery, ISRN Biochem., 2013, 18, 10.1155/2013/238428
Boyd, 2015, Traumatic brain injury opens blood-brain barrier to stealth liposomes via an enhanced permeability and retention (EPR)-like effect, J. Drug. Target., 23, 847, 10.3109/1061186X.2015.1034280
Clond, M.A., Lee, B.S., Yu, J.J., Singer, M.B., Amano, T., Lamb, A.W., Drazin, D., Kateb, B., Ley, E.J., and Yu, J.S. (2013). Reactive oxygen species-activated nanoprodrug of Ibuprofen for targeting traumatic brain injury in mice. PLoS ONE, 8.
Xu, 2016, Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury, Adv. Funct. Mater., 26, 4124, 10.1002/adfm.201504416
Bharadwaj, 2016, Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size, Sci. Rep., 6, 29988, 10.1038/srep29988
Cruz, 2016, Effect of PLGA NP size on efficiency to target traumatic brain injury, J. Control. Release, 223, 31, 10.1016/j.jconrel.2015.12.029
Zhang, 2017, Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model, J. Control. Release, 249, 173, 10.1016/j.jconrel.2017.01.032
Yoo, 2017, Core-Cross-Linked Nanoparticles Reduce Neuroinflammation and Improve Outcome in a Mouse Model of Traumatic Brain Injury, ACS Nano, 11, 8600, 10.1021/acsnano.7b03426
Bharadwaj, 2018, Blood-brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury, Nanomedicine, 14, 2155, 10.1016/j.nano.2018.06.004
Nance, 2016, Nanoscale effects in dendrimer-mediated targeting of neuroinflammation, Biomaterials, 101, 96, 10.1016/j.biomaterials.2016.05.044
Nance, 2015, Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury, J. Control. Release, 214, 112, 10.1016/j.jconrel.2015.07.009
Nance, 2012, A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue, Sci. Transl. Med., 4, 149ra119, 10.1126/scitranslmed.3003594
Mishra, 2014, Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest, ACS Nano, 8, 2134, 10.1021/nn404872e
Alnasser, Y., Kambhampati, S.P., Nance, E., Rajbhandari, L., Shrestha, S., Venkatesan, A., Kannan, R.M., and Kannan, S. (2018). Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture. Molecules, 23.
Curtis, 2018, Colloidal stability as a determinant of nanoparticle behavior in the brain, Colloids Surf. B Biointerfaces, 170, 673, 10.1016/j.colsurfb.2018.06.050
Zhang, 2017, Strategies to enhance the distribution of nanotherapeutics in the brain, J. Control. Release, 267, 232, 10.1016/j.jconrel.2017.07.028
Mastorakos, 2016, Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain, Small, 12, 678, 10.1002/smll.201502554
Karatas, 2009, A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood-Brain Barrier and Provides Neuroprotection, J. Neurosci., 29, 13761, 10.1523/JNEUROSCI.4246-09.2009
Zhao, 2011, Postacute ischemia vascular endothelial growth factor transfer by transferrin-targeted liposomes attenuates ischemic brain injury after experimental stroke in rats, Hum. Gene Ther., 22, 207, 10.1089/hum.2010.111
Cruz, 2016, Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging, Nano Res., 9, 1276, 10.1007/s12274-016-1023-z
Xu, 2011, Efficacy of CG(3)R(6)TAT nanoparticles self-assembled from a novel antimicrobial peptide for the treatment of Candida albicans meningitis in rabbits, Chemotherapy, 57, 417, 10.1159/000330855
Tang, 2015, Anti-transferrin receptor-modified amphotericin B-loaded PLA-PEG nanoparticles cure Candidal meningitis and reduce drug toxicity, Int. J. Nanomed., 10, 6227, 10.2147/IJN.S84656
Wang, 2016, Electroresponsive Nanoparticles Improve Antiseizure Effect of Phenytoin in Generalized Tonic-Clonic Seizures, Neurother. J. Am. Soc. Exp. Neurother., 13, 603
Hu, 2011, Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson’s disease, Int. J. Pharm., 415, 273, 10.1016/j.ijpharm.2011.05.062
Kwon, 2016, Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease, ACS Nano, 10, 2860, 10.1021/acsnano.5b08045
Monopoli, 2012, Biomolecular coronas provide the biological identity of nanosized materials, Nat. Nanotechnol., 7, 779, 10.1038/nnano.2012.207
Bitner, 2012, Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury, ACS Nano, 6, 8007, 10.1021/nn302615f
Reddy, 2008, Superoxide dismutase-loaded PLGA nanoparticles protect cultured human neurons under oxidative stress, Appl. Biochem. Biotechnol., 151, 565, 10.1007/s12010-008-8232-1
Singhal, 2013, Nanoparticle-mediated catalase delivery protects human neurons from oxidative stress, Cell Death Dis., 4, e903, 10.1038/cddis.2013.362
Reddy, 2009, Nanoparticle-mediated delivery of superoxide dismutase to the brain: An effective strategy to reduce ischemia-reperfusion injury, FASEB J., 23, 1384, 10.1096/fj.08-116947
Jiang, 2015, SOD1 nanozyme salvages ischemic brain by locally protecting cerebral vasculature, J. Control. Release, 213, 36, 10.1016/j.jconrel.2015.06.021
Lin, 2012, Delivery of large molecules via poly(butyl cyanoacrylate) nanoparticles into the injured rat brain, Nanotechnology, 23, 165101, 10.1088/0957-4484/23/16/165101
Mann, 2016, A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries, Nat. Commun., 7, 11980, 10.1038/ncomms11980
Joo, 2016, Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain, Nanoscale Horiz., 1, 407, 10.1039/C6NH00082G
Lai, 2013, Liposomes for brain delivery, Expert Opin. Drug Deliv., 10, 1003, 10.1517/17425247.2013.766714
Ishii, 2012, Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506, FASEB J., 27, 1362, 10.1096/fj.12-221325
Orthmann, 2012, Treatment of Experimental Brain Metastasis with MTO-Liposomes: Impact of Fluidity and LRP-Targeting on the Therapeutic Result, Pharm. Res., 29, 1949, 10.1007/s11095-012-0723-7
Pardeshi, 2012, Solid lipid based nanocarriers: An overview, Acta Pharm., 62, 433, 10.2478/v10007-012-0040-z
Blasi, 2007, Solid lipid nanoparticles for targeted brain drug delivery, Adv. Drug Deliv. Rev., 59, 454, 10.1016/j.addr.2007.04.011
Moghimi, 1995, Mechanisms regulating body distribution of nanospheres conditioned with pluronic and tetronic block co-polymers, Adv. Drug Deliv. Rev., 16, 183, 10.1016/0169-409X(95)00024-2
Lenaerts, 1995, Nanocapsules with a reduced liver uptake: Targeting of phthalocyanines to EMT-6 mouse mammary tumour in vivo, Eur. J. Pharm. Biopharm., 41, 38
Wang, 2002, Enhanced brain targeting by synthesis of 3’, 5’-dioctanoyl-5-fluoro-2’-deoxyuridine and incorporation into solid lipid nanoparticles, Eur. J. Pharm. Biopharm., 54, 285, 10.1016/S0939-6411(02)00083-8
Martins, 2012, Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies, Int. J. Pharm., 439, 49, 10.1016/j.ijpharm.2012.09.054
Kreuter, 1995, Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles), Brain Res., 674, 171, 10.1016/0006-8993(95)00023-J
Ramge, 2000, Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells, Eur. J. Neurosci., 12, 1931, 10.1046/j.1460-9568.2000.00078.x
Kulkarni, 2010, Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer’s disease, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2, 35, 10.1002/wnan.59
Koffie, 2011, Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging, Proc. Natl. Acad. Sci. USA, 108, 18837, 10.1073/pnas.1111405108
Kuo, 2012, Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells, Colloids Surf. B Biointerfaces, 91, 242, 10.1016/j.colsurfb.2011.11.007
Voigt, 2014, Surfactants, not size or zeta-potential influence blood–brain barrier passage of polymeric nanoparticles, Eur. J. Pharm. Biopharm., 87, 19, 10.1016/j.ejpb.2014.02.013
Pardridge, 1992, Recent Developments in Peptide Drug Delivery to the Brain, Pharmacol. Toxicol., 71, 3, 10.1111/j.1600-0773.1992.tb00512.x
Albertazzi, 2013, In Vivo Distribution and Toxicity of PAMAM Dendrimers in the Central Nervous System Depend on Their Surface Chemistry, Mol. Pharm., 10, 249, 10.1021/mp300391v
Cheng, 2014, Blood-brain barrier permeable gold nanoparticles: An efficient delivery platform for enhanced malignant glioma therapy and imaging, Small, 10, 5137, 10.1002/smll.201400654
Sela, 2015, Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB), J. Nanobiotechnol., 13, 71, 10.1186/s12951-015-0133-1
Setyawati, 2017, Gold Nanoparticles Induced Endothelial Leakiness Depends on Particle Size and Endothelial Cell Origin, ACS Nano, 11, 5020, 10.1021/acsnano.7b01744
Peng, 2019, Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness, Nat. Nanotechnol., 14, 279, 10.1038/s41565-018-0356-z
Setyawati, 2013, Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin, Nat. Commun., 4, 1673, 10.1038/ncomms2655
Wang, 2018, Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles, Chem. Mater., 30, 3759, 10.1021/acs.chemmater.8b00840
Tee, 2019, Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness, Nanotoxicology, 13, 682, 10.1080/17435390.2019.1571646
Chen, X. (2008). Sieve Extremum Estimation. The New Palgrave Dictionary of Economics, Palgrave Macmillan UK.
Trickler, 2010, Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells, Toxicol. Sci., 118, 160, 10.1093/toxsci/kfq244
Xu, 2015, Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model, Int. J. Nanomed., 10, 6105
Neal, 2019, A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs, Stem Cell Rep., 12, 1380, 10.1016/j.stemcr.2019.05.008
Mo, 2016, Tailoring Particle Size of Mesoporous Silica Nanosystem To Antagonize Glioblastoma and Overcome Blood–Brain Barrier, ACS Appl. Mater. Interfaces, 8, 6811, 10.1021/acsami.5b11730
Song, 2017, In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood–Brain Barrier, ACS Appl. Mater. Interfaces, 9, 20410, 10.1021/acsami.7b03504
Li, 2016, Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells, Nanoscale, 8, 16662, 10.1039/C6NR05055G
Lu, 2016, Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood-brain barrier penetration capabilities, Int. J. Nanomed., 11, 6325, 10.2147/IJN.S119252
Abutarboush, 2018, Brain oxygenation with a non-vasoactive perfluorocarbon emulsion in a rat model of traumatic brain injury, Microcirculation, 25, e12441, 10.1111/micc.12441
Zhou, 2008, Perfluorocarbon emulsions improve cognitive recovery after lateral fluid percussion brain injury in rats, Neurosurgery, 63, 799, 10.1227/01.NEU.0000325493.51900.53
Daugherty, 2004, Perfluorocarbon emulsion improves cerebral oxygenation and mitochondrial function after fluid percussion brain injury in rats, Neurosurgery, 54, 1223, 10.1227/01.NEU.0000119238.68938.5D
Graham, K., Moon-Massat, P.F., and Unger, E.C. (2017). 2017 Military Supplement: Dodecafluoropentane Emulsion (Ddfpe) as a Resuscitation Fluid for Treatment of Hemorrhagic Shock and Traumatic Brain Injury: A Review. Shock.
Mullah, 2016, Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats, Brain Res., 1634, 132, 10.1016/j.brainres.2016.01.012
Abutarboush, 2014, Effects of perfluorocarbon dodecafluoropentane (NVX-108) on cerebral microvasculature in the healthy rat, Curr. Drug Discov. Technol., 11, 220, 10.2174/1570163811666140709110301
Sharma, 2018, Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics, Theranostics, 8, 5529, 10.7150/thno.29039
Ping, 2014, PEG-PDLLA micelle treatment improves axonal function of the corpus callosum following traumatic brain injury, J. Neurotrauma., 31, 1172, 10.1089/neu.2013.3147