A Possible Smoking Susceptibility Locus on Chromosome 11p12: Evidence from Sex-limitation Linkage Analyses in a Sample of Australian Twin Families

Behavior Genetics - Tập 36 - Trang 87-99 - 2005
Katherine I Morley1,2, Sarah E Medland1,3, Manuel AR Ferreira1, Michael T Lynskey1,4, Grant W Montgomery1, Andrew C Heath4, Pamela AF Madden4, Nicholas G Martin1
1Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
2Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia
3Department of Psychology, The University of Queensland, Queensland, Australia
4Department of Psychiatry, Washington University St. Louis, St Louis, USA

Tóm tắt

Many twin studies have identified sex differences in the influence of genetic and environmental factors on smoking behaviors. We explore the evidence for sex differences for smoking initiation and cigarette consumption in a sample of Australian twin families, and extend these models to incorporate sex differences in linkage analyses for these traits. We further examine the impact of including or excluding non-smokers in genetic analyses of tobacco consumption. Accounting for sex differences improved linkage results in some instances. We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies.

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