A Novel Panel of Cerebrospinal Fluid Biomarkers for the Differential Diagnosis of Alzheimer’s Disease versus Normal Aging and Frontotemporal Dementia

Dementia and Geriatric Cognitive Disorders - Tập 24 Số 6 - Trang 434-440 - 2007
Anja Hviid Simonsen1,2, J. H. McGuire1, Vladimir N. Podust3, N.-O. Hagnelius4, Torbjörn K. Nilsson5, Elizabeth Kapaki6, Dimitrios Vassilopoulos6, Gunhild Waldemar2
1Biomarker Discovery Center® Facility, Ciphergen Biosystems Inc., and
2Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark
3Biomarker Discovery Center Facility, Ciphergen Biosystems Inc., Fremont, Calif., USA
4Departments of Geriatrics and Clinical Chemistry and
5Department of Clinical Chemistry, University Hospital, Örebro, Sweden
6Department of Neurology, Eginition University Hospital, University of Athens, Athens, Greece

Tóm tắt

<i>Background:</i> An early and accurate diagnosis of Alzheimer’s disease (AD) is important in order to initiate symptomatic treatment with currently approved drugs and will be of even greater importance with the advent of disease-modifying compounds. <i>Methods:</i> Protein profiles of human cerebrospinal fluid samples from patients with AD (n = 85), frontotemporal dementia (n = 20), and healthy controls (n = 32) were analyzed by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to verify previously discovered biomarkers. <i>Results:</i> We verified 15 protein biomarkers that were able to differentiate between AD and controls, and 7 of these 15 markers also differentiated AD from FTD. <i>Conclusion:</i> A panel of cerebrospinal fluid protein markers was verified by a proteomics technology which may potentially improve the accuracy of the AD diagnosis.

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Tài liệu tham khảo

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Thông tin xuất bản

Dementia and Geriatric Cognitive Disorders

Tập 24 Số 6

434-440

Thông tin tác giả