Teruaki Mukaiyama1, Akihiko Ishida1
1Department of Chemistry, Faculty of Science, The University of Tokyo
Tóm tắt
Abstract
A new synthesis of vitamin A was successfully accomplished by reducing retinal, prepared by the reaction of 3-methyl-1-trimethylsiloxy-1,3-butadiene (III) with β-ionylideneacetaldehyde dimethyl acetal (VII) followed by the elimination of methanol with tertiary amine such as 1,5-diazabicyclo[5.4.0]undecene-5. The intermediate, β-ionylideneacetaldehyde (V), was also prepared according to the same procedure starting from β-cyclocitral dimethyl acetal (II).
